SNORD3B-2 promotes endometrial carcinoma progression by 2′-O-methylation modification of PLK1 and regulating RAB17 alternative splice

Xi Chen; Yuping Du; Bumin Xie; Qianhui Li; Yumeng Ji; Yang Han; Xiujie Sheng; Shuo Chen; Yang Zhao

doi:10.1016/j.gendis.2024.101329

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Rapid Communication | Open Access

SNORD3B-2 promotes endometrial carcinoma progression by 2′-O-methylation modification of PLK1 and regulating RAB17 alternative splice

Xi Chen^{^a^,^b^,^c^,^d^,^e^,^f^,¹}, Yuping Du^{^a^,^b^,^c^,^d^,^e^,^f^,¹}, Bumin Xie^{^a^,^b^,^c^,^d^,^e^,^f^,¹}, Qianhui Li^{^a^,^b^,^c^,^d^,^e^,^f}, Yumeng Ji^{^a^,^b^,^c^,^d^,^e^,^f}, Yang Han^{^a^,^b^,^c^,^d^,^e^,^f}, Xiujie Sheng^{^a^,^b^,^c^,^d^,^e^,^f}(

), Shuo Chen^{^a^,^b^,^c^,^d^,^e^,^f}(

), Yang Zhao^{^a^,^b^,^c^,^d^,^e^,^f}(

)

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China

Department of Gynecologic Oncology Research Office, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China

Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China

Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China

Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China

Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China

Peer review under responsibility of Chongqing Medical University.

¹ These authors contributed equally to this work.

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Genes & Diseases

Volume 12 Issue 2,
March 2025

Article number: 101329

DOI: 10.1016/j.gendis.2024.101329

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Cite this article:

Chen X, Du Y, Xie B, et al. SNORD3B-2 promotes endometrial carcinoma progression by 2′-O-methylation modification of PLK1 and regulating RAB17 alternative splice. Genes & Diseases, 2025, 12(2): 101329. https://doi.org/10.1016/j.gendis.2024.101329

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Received: 11 November 2023

Published: 17 May 2024

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).