AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
PDF (1.2 MB)
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Rapid Communication | Open Access

Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT/mTOR signaling pathway

Haixia Luoa,1Jingjing Changa,1Yiting Rena,1Xiu ZhangaYuanxing LiaMiao HuoaHongyuan WangaXin YangbJianbing LiucQingmei ZhangdYueyang ZhaoaWei Wanga( )
Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China
Pathology Department, School of Medicine, Stanford University, California 94305, USA
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030001, China
School of Applied Science, Taiyuan University of Science and Technology, Taiyuan, Shanxi 030024, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

Show Author Information

References

1

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249.

2

Wafai R, Williams ED, de Souza E, et al. Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer — insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system. Breast Cancer Res. 2020;22(1):136.

3

Luo H, Li Y, Zhao Y, et al. Comprehensive analysis of circRNA expression profiles during cervical carcinogenesis. Front Oncol. 2021;11:676609.

4

Huang W, Zhu J, Shi H, Wu Q, Zhang C. ITGA2 overexpression promotes esophageal squamous cell carcinoma aggression via FAK/AKT signaling pathway. Onco Targets Ther. 2021;14:3583–3596.

5

Liao Y, Huang J, Liu P, et al. Downregulation of LNMAS orchestrates partial EMT and immune escape from macrophage phagocytosis to promote lymph node metastasis of cervical cancer. Oncogene. 2022;41(13):1931–1943.

Genes & Diseases
Article number: 101328
Cite this article:
Luo H, Chang J, Ren Y, et al. Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT/mTOR signaling pathway. Genes & Diseases, 2025, 12(2): 101328. https://doi.org/10.1016/j.gendis.2024.101328

94

Views

1

Downloads

1

Crossref

1

Web of Science

1

Scopus

0

CSCD

Altmetrics

Received: 05 September 2023
Published: 18 May 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Return