AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Genes & Diseases Article
PDF (1.3 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Rapid Communication | Open Access

SET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia

Akhilesh Kaushal, Samrat Roy Choudhury( )
Pediatric Hematology-Oncology, Department of Pediatrics, Arkansas Children’s Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA

Peer review under responsibility of Chongqing Medical University.

Show Author Information

References

1

Van Vlierberghe P, van Grotel M, Tchinda J, et al. The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. Blood. 2008;111(9):4668-4680.
Crossref Google Scholar
2

Shen Y, Yang D, Zhang R, et al. The outcome of acute leukemia patients with SET-NUP214 fusion after allogeneic stem cell transplantation. Front Oncol. 2023;13:1256043.
Crossref Google Scholar
3

Bensberg M, Rundquist O, Selimović A, et al. TET2 as a tumor suppressor and therapeutic target in T-cell acute lymphoblastic leukemia. Proc Natl Acad Sci USA. 2021;118(34):e2110758118.
Crossref Google Scholar
4

Malinge S, Chlon T, Doré LC, et al. Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes. Blood. 2013;122(14):e33-e43.
Crossref Google Scholar
5

Hombría JCG, Lovegrove B. Beyond homeosis: HOX function in morphogenesis and organogenesis. Differentiation. 2003;71(8):461-476.
Crossref Google Scholar
Genes & Diseases
Volume 12 Issue 2,
March 2025
Article number: 101320
DOI: 10.1016/j.gendis.2024.101320
Cite this article:
Kaushal A, Choudhury SR. SET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia. Genes & Diseases, 2025, 12(2): 101320. https://doi.org/10.1016/j.gendis.2024.101320

64

Views

1

Downloads

0

Crossref

0

Web of Science

0

Scopus

0

CSCD

Altmetrics
Received: 15 January 2024
Published: 07 May 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Return