AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Genes & Diseases Article
PDF (1.3 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Rapid Communication | Open Access

The AKT1-mTOR signaling cascade is crucial for SOX3 to promote hepatocarcinogenesis

Yang Liua,1, Feifei Songa,1, Xianhuang Zenga, Siqi Yanga, Zixu Zhaib, Ze Wangb,c, Wajeeha Naza, Tanzeel Yousafa, Junwei Sund, Yangjun Zhange, Ying Zhoua, Mingxiong Guob,c, Yun-Bo Shif( ), Geng Tiang( ), Guihong Suna,h( )
Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China
Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
Ecological Research Center, College of Science, Tibet University, Lhasa, Tibet 850012, China
Department of Hepatic & Biliary & Pancreatic Surgery, Hubei Cancer Hospital, Affiliated Hubei Cancer Hospital of Huazhong University of Science and Technology, Wuhan, Hubei 430079, China
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
Section on Molecular Morphogenesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD 20892, USA
Department of Oncology, The First Affiliated Hospital of Shenzhen University, The Second People’s Hospital of Shenzhen, Shenzhen, Guangdong 518035, China
Hubei Provincial Key Laboratory of Allergy and Immunology, Wuhan, Hubei 430071, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

Show Author Information

References

1

Bowles J, Schepers G, Koopman P. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol. 2000;227(2):239-255.
Crossref Google Scholar
2

Zhang S, Zhu C, Zhu L, et al. Oncogenicity of the transcription factor SOX8 in hepatocellular carcinoma. Med Oncol. 2014;31(4):918.
Crossref Google Scholar
3

Li MM, Tang YQ, Gong YF, et al. Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma. BMC Cancer. 2019;19(1):851.
Crossref Google Scholar
4

Feng Y, Xiao F, Yang N, et al. Overexpression of Sox3 is associated with promoted tumor progression and poor prognosis in hepatocellular carcinoma. Int J Clin Exp Pathol. 2017;10(7):7873-7881.
Google Scholar
5

Ho C, Wang C, Mattu S, et al. AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways. Hepatology. 2012;55(3):833-845.
Crossref Google Scholar
Genes & Diseases
Volume 12 Issue 2,
March 2025
Article number: 101316
DOI: 10.1016/j.gendis.2024.101316
Cite this article:
Liu Y, Song F, Zeng X, et al. The AKT1-mTOR signaling cascade is crucial for SOX3 to promote hepatocarcinogenesis. Genes & Diseases, 2025, 12(2): 101316. https://doi.org/10.1016/j.gendis.2024.101316

73

Views

1

Downloads

0

Crossref

0

Web of Science

0

Scopus

0

CSCD

Altmetrics
Received: 18 September 2023
Published: 07 May 2024
© 2024 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Return