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Rapid Communication | Open Access

Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma

Yueying Gaoa,b,1, Jinyang Yua,1, Zhi Lic,1, Kefan Liub, Jiwei Pana, Ya Zhanga, Yanlin Maa( ), Jiwei Zhangc( ), Zhigang Liud( ), Yongsheng Lia,b( )
Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Department of Reproductive Medicine, Hainan Provincial Clinical Research Center for Thalassemia, Key Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education, The First Affiliated Hospital of Hainan Medical University, College of Biomedical Information and Engineering, Hainan Medical University, Haikou, Hainan 571101, China
School of Interdisciplinary Medicine and Engineering, Harbin Medical University, Harbin, Heilongjiang 150081, China
The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Guangzhou, Guangdong 510000, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

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Genes & Diseases
Volume 12 Issue 2,
March 2025
Article number: 101302
DOI: 10.1016/j.gendis.2024.101302
Cite this article:
Gao Y, Yu J, Li Z, et al. Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma. Genes & Diseases, 2025, 12(2): 101302. https://doi.org/10.1016/j.gendis.2024.101302

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Received: 16 November 2023
Published: 08 April 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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