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Full Length Article | Open Access

The effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I

Junjun Quana,b,1, Zhongli Jiaa,c,1, Lingjuan Liua,b, Jie Tiana,b( )
Department of Cardiology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China
Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing 400014, China
Department of Pediatrics, The People’s Hospital of Leshan, Leshan, Sichuan 614000, China

Peer review under the responsibility of the Genes & Diseases Editorial Office, in alliance with the Association of Chinese Americans in Cancer Research (ACACR, Baltimore, MD, USA).

1 These authors contributed equally to this work and shared the first authorship.

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Abstract

Aging is an independent risk factor for cardiovascular diseases. Cardiac diastolic dysfunction (CDD), ultimately leading to heart failure with preserved ejection fraction (HFpEF), is prevalent among older individuals. Although therapeutics have made great progress, preventive strategies remain unmet medical needs. Green tea catechins have been shown to be effective in improving aging-related cardiovascular and cerebral disorders in animal models and patients. However, little attention has been paid to whether long-term administration of epigallocatechin gallate (EGCG), the major bioactive ingredient of green tea catechins, could prevent the onset and progression of CDD. In this study, 12-month-old female mice were orally administered 50, 100 and 200 mg EGCG mixed with drinking water for 6 months. Aged mice (18 months old) exhibited the major features of HFpEF, including CDD with pEF, cardiac fibrosis, increased cardiomyocyte apoptosis, and mitochondrial damages, as well as elevated A/B-type natriuretic peptide. Cardiac troponin I (cTnI) expression was also reduced. Long-term administration of 100 or 200 mg EGCG prevented aging-related CDD and exercise capacity decline, along with alleviating myocardial apoptosis and mitochondria damage. The transcription and protein expression of cTnI were increased, which might be achieved by inhibiting the expression and activity of histone deacetylase 1 (HDAC1), and reducing its binding level near cTnI’s promoter, thereby elevating acetylated histone 3 (AcH3) and acetylated lysine 9 on histone H3 (AcH3K9) in the aged mice. We provide a novel insight that long-term administration of EGCG is a potentially effective strategy in preventing aging-related CDD and cTnI expression decline.

Keywords

AgingCardiac diastolic dysfunctionCardiac troponin IEpigallocatechin gallateHistone deacetylase 1

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Genes & Diseases
Volume 12 Issue 2,
March 2025
Article number: 101284
DOI: 10.1016/j.gendis.2024.101284
Cite this article:
Quan J, Jia Z, Liu L, et al. The effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I. Genes & Diseases, 2025, 12(2): 101284. https://doi.org/10.1016/j.gendis.2024.101284

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Received: 29 November 2023
Revised: 30 January 2024
Accepted: 07 March 2024
Published: 03 April 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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