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Rapid Communication | Open Access

Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma

Shufan ZhangaRong JiangaChangguo WangbManqiu YangaTao WangcJianzhou Cuid,e,fGuangbin LigShaomu ChengMoli Huanga( )
School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu 215123, China
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
Cambridge-Suda Genomic Research Center, Soochow University, Suzhou, Jiangsu 215123, China
Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore
Immunology Programme, Life Science Institute, National University of Singapore, Singapore 117456, Singapore
NUS-Cambridge Immunophenotyping Centre, National University of Singapore, Singapore 117456, Singapore
Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

Peer review under responsibility of Chongqing Medical University.

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References

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Zhao SG, Chen WS, Das R, et al. Clinical and genomic implications of luminal and basal subtypes across carcinomas. Clin Cancer Res. 2019;25(8):2450-2457.

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Camolotto SA, Pattabiraman S, Mosbruger TL, et al. FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. Elife. 2018;7:38579.

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Zewdu R, Mehrabad EM, Ingram K, et al. An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma. Elife. 2021;10:e66788.

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Kim SH, Turnbull J, Guimond S. Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. J Endocrinol. 2011;209(2):139-151.

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Guo M, Tomoshige K, Meister M, et al. Gene signature driving invasive mucinous adenocarcinoma of the lung. EMBO Mol Med. 2017;9(4):462-481.

Genes & Diseases
Article number: 101278
Cite this article:
Zhang S, Jiang R, Wang C, et al. Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma. Genes & Diseases, 2025, 12(2): 101278. https://doi.org/10.1016/j.gendis.2024.101278

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Received: 26 September 2023
Published: 26 March 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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