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Rapid Communication | Open Access

Reduction of Atp5b protects mice from diet-induced obesity

Xiaohua Huanga,b,1Binting Qina,b,1Zhengfeng FangaLianqiang CheaYan LinaShengyu XuaYong ZhuoaLun HuaaXuemei JiangaMengmeng SuncHairui WangdDe Wua,bQingqiang Longe( )Bin Fenga,b( )
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China
Key Laboratory of Animal Disease-Resistant Nutrition of Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan 611130, China
College of Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China
Chengdu Research Base of Giant Panda Breeding, Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu, Sichuan 610081, China
Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China

Peer review under responsibility of Chongqing Medical University.

1 These two authors contributed equally to this work.

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References

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Blüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288-298.

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Pillon NJ, Loos RJF, Marshall SM, Zierath JR. Metabolic consequences of obesity and type 2 diabetes: balancing genes and environment for personalized care. Cell. 2021;184(6):1530-1544.

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Bernardi P, Di Lisa F, Fogolari F, Lippe G. From ATP to PTP and back: a dual function for the mitochondrial ATP synthase. Circ Res. 2015;116(11):1850-1862.

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Li H, Liu Y, Xue Z, et al. Adamantaniline derivatives target ATP5B to inhibit translation of hypoxia inducible factor-1α. Adv Sci. 2023;10(25):e2301071.

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Xu Y, Tan H, Liu K, et al. Targeted inhibition of ATP5B gene prevents bone erosion in collagen-induced arthritis by inhibiting osteoclastogenesis. Pharmacol Res. 2021;165:105458.

Genes & Diseases
Article number: 101276
Cite this article:
Huang X, Qin B, Fang Z, et al. Reduction of Atp5b protects mice from diet-induced obesity. Genes & Diseases, 2025, 12(2): 101276. https://doi.org/10.1016/j.gendis.2024.101276

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Received: 07 November 2023
Published: 22 March 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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