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Rapid Communication | Open Access

The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma

Jianhong Zhang1Chengyang Song1Xiuqin FengQian YuXueying Yang( )
Department of Thoracic and Cardiac Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work and shared the first authorship.

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References

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Jew B, Alvarez M, Rahmani E, et al. Accurate estimation of cell composition in bulk expression through robust integration of single-cell information. Nat Commun. 2020;11(1):1971.

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van de Donk NWCJ, Usmani SZ, Yong K. CAR T-cell therapy for multiple myeloma: state of the art and prospects. Lancet Haematol. 2021;8(6):e446-e461.

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Kurebayashi Y, Emoto K, Hayashi Y, et al. Comprehensive immune profiling of lung adenocarcinomas reveals four immunosubtypes with plasma cell subtype a negative indicator. Cancer Immunol Res. 2016;4(3):234-247.

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Lohr M, Edlund K, Botling J, et al. The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer. Cancer Lett. 2013;333(2):222-228.

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Patil NS, Nabet BY, Müller S, et al. Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer. Cancer Cell. 2022;40(3):289-300.e4.

Genes & Diseases
Article number: 101274
Cite this article:
Zhang J, Song C, Feng X, et al. The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma. Genes & Diseases, 2025, 12(2): 101274. https://doi.org/10.1016/j.gendis.2024.101274

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Received: 01 October 2023
Published: 22 March 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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