Pdgfrα⁺ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs

Fiore D, Judson RN, Low M, et al. Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration. Stem Cell Res. 2016;17(1):161-169.

Lemos DR, Babaeijandaghi F, Low M, et al. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat Med. 2015;21(7):786-794.

Ito T, Ogawa R, Uezumi A, et al. Imatinib attenuates severe mouse dystrophy and inhibits proliferation and fibrosis-marker expression in muscle mesenchymal progenitors. Neuromuscul Disord. 2013;23(4):349-356.

Uezumi A, Ito T, Morikawa D, et al. Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle. J Cell Sci. 2011;124(Pt 21):3654-3664.

Moyer AL, Wagner KR. Regeneration versus fibrosis in skeletal muscle. Curr Opin Rheumatol. 2011;23(6):568-573.

Soliman H, Theret M, Scott W, et al. Multipotent stromal cells: one name, multiple identities. Cell Stem Cell. 2021;28(10):1690-1707.

Contreras O, Rossi FMV, Theret M. Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors-time for new definitions. Skelet Muscle. 2021;11(1):16.

Theret M, Rossi FMV, Contreras O. Evolving roles of muscle-resident fibro-adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging. Front Physiol. 2021;12:673404.

Giuliani G, Rosina M, Reggio A. Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease. FEBS J. 2022;289(21):6484-6517.

Dong Y, Silva KA, Dong Y, Zhang L. Glucocorticoids increase adipocytes in muscle by affecting IL-4 regulated FAP activity. FASEB J. 2014;28(9):4123-4132.

Uezumi A, Fukada SI, Yamamoto N, Takeda S, Tsuchida K. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol. 2010;12(2):143-152.

Joe AWB, Yi L, Natarajan A, et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol. 2010;12(2):153-163.

Uezumi A, Nakatani M, Ikemoto-Uezumi M, et al. Cell-surface protein profiling identifies distinctive markers of progenitor cells in human skeletal muscle. Stem Cell Rep. 2016;7(2):263-278.

Farup J, Just J, de Paoli F, et al. Human skeletal muscle CD90⁺ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients. Cell Metab. 2021;33(11):2201-2214.e11.

Malecova B, Gatto S, Etxaniz U, et al. Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy. Nat Commun. 2018;9(1):3670.

Liu X, Ning AY, Chang NC, et al. Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury. Muscles Ligaments Tendons J. 2016;6(1):6-15.

Giuliani G, Vumbaca S, Fuoco C, et al. SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors. Cell Death Dis. 2021;12(1):122.

Scott RW, Arostegui M, Schweitzer R, Rossi FMV, Underhill TM. Hic1 defines quiescent mesenchymal progenitor subpopulations with distinct functions and fates in skeletal muscle regeneration. Cell Stem Cell. 2019;25(6):797-813.e9.

Oprescu SN, Yue F, Qiu J, Brito LF, Kuang S. Temporal dynamics and heterogeneity of cell populations during skeletal muscle regeneration. iScience. 2020;23(4):100993.

Leinroth AP, Mirando AJ, Rouse D, et al. Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations. Cell Rep. 2022;39(6):110785.

Lin H, Ma X, Sun Y, et al. Decoding the transcriptome of denervated muscle at single-nucleus resolution. J Cachexia Sarcopenia Muscle. 2022;13(4):2102-2117.

Vallecillo-García P, Orgeur M, Vom Hofe-Schneider S, et al. Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nat Commun. 2017;8(1):1218.

Rebolledo DL, González D, Faundez-Contreras J, et al. Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN₂ independently of TGF-Β. Matrix Biol. 2019;82:20-37.

Contreras O, Cruz-Soca M, Theret M, et al. Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro-adipogenic progenitors. J Cell Sci. 2019;132(19):jcs232157.

Contreras O, Soliman H, Theret M, Rossi FMV, Brandan E. TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα⁺ fibroblasts. J Cell Sci. 2020;133(12):jcs242297.

Mueller AA, van Velthoven CT, Fukumoto KD, Cheung TH, Rando TA. Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis. Nature. 2016;540(7632):276-279.

Córdova-Casanova A, Cruz-Soca M, Chun J, Casar JC, Brandan E. Activation of the ATX/LPA/LPARs axis induces a fibrotic response in skeletal muscle. Matrix Biol. 2022;109:121-139.

Ogawa-Wong A, Carmody C, Le K, et al. Modulation of deiodinase types 2 and 3 during skeletal muscle regeneration. Metabolites. 2022;12(7):612.

Moratal C, Raffort J, Arrighi N, et al. IL-1β- and IL-4-polarized macrophages have opposite effects on adipogenesis of intramuscular fibro-adipogenic progenitors in humans. Sci Rep. 2018;8(1):17005.

Zhang H, Liu M, Kim HT, Feeley BT, Liu X. Preconditioning improves muscle regeneration after ischemia-reperfusion injury. J Orthop Res. 2021;39(9):1889-1897.

Arrighi N, Moratal C, Clément N, et al. Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle. Cell Death Dis. 2015;6(4):e1733.

Gorski T, Mathes S, Krützfeldt J. Uncoupling protein 1 expression in adipocytes derived from skeletal muscle fibro/adipogenic progenitors is under genetic and hormonal control. J Cachexia Sarcopenia Muscle. 2018;9(2):384-399.

Kopinke D, Roberson EC, Reiter JF. Ciliary hedgehog signaling restricts injury-induced adipogenesis. Cell. 2017;170(2):340-351.e12.

Prados B, Del Toro R, MacGrogan D, et al. Heterotopic ossification in mice overexpressing Bmp2 in Tie2⁺ lineages. Cell Death Dis. 2021;12(8):729.

Eisner C, Cummings M, Johnston G, et al. Murine tissue-resident PDGFRα⁺ fibro-adipogenic progenitors spontaneously acquire osteogenic phenotype in an altered inflammatory environment. J Bone Miner Res. 2020;35(8):1525-1534.

Oishi T, Uezumi A, Kanaji A, et al. Osteogenic differentiation capacity of human skeletal muscle-derived progenitor cells. PLoS One. 2013;8(2):e56641.

Sang X, Wang Z, Shi P, Li Y, Cheng L. CGRP accelerates the pathogenesis of neurological heterotopic ossification following spinal cord injury. Artif Cells Nanomed Biotechnol. 2019;47(1):2569-2574.

Tseng HW, Kulina I, Girard D, et al. Interleukin-1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification. J Bone Miner Res. 2022;37(3):531-546.

Lees-Shepard JB, Yamamoto M, Biswas AA, et al. Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva. Nat Commun. 2018;9(1):471.

Natarajan A, Lemos DR, Rossi FMV. Fibro/adipogenic progenitors: a double-edged sword in skeletal muscle regeneration. Cell Cycle. 2010;9(11):2045-2046.

Agha O, Mueller-Immergluck A, Liu M, et al. Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations. JOR Spine. 2020;3(2):e1091.

Agha O, Diaz A, Davies M, Kim HT, Liu X, Feeley BT. Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors. Ann N Y Acad Sci. 2021;1490(1):13-28.

Wosczyna MN, Konishi CT, Perez Carbajal EE, et al. Mesenchymal stromal cells are required for regeneration and homeostatic maintenance of skeletal muscle. Cell Rep. 2019;27(7):2029-2035.e5.

Uezumi A, Ikemoto-Uezumi M, Zhou H, et al. Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia. J Clin Investig. 2021;131(1):e139617.

Saito Y, Chikenji TS, Matsumura T, Nakano M, Fujimiya M. Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors. Nat Commun. 2020;11(1):889.

Harvey T, Flamenco S, Fan CM. A Tppp3⁺Pdgfra⁺ tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis. Nat Cell Biol. 2019;21(12):1490-1503.

Madarampalli B, Watts GFM, Panipinto PM, Nguygen HN, Brenner MB, Noss EH. Interactions between cadherin-11 and platelet-derived growth factor receptor-alpha signaling link cell adhesion and proliferation. Biochim Biophys Acta Mol Basis Dis. 2019;1865(6):1516-1524.

Park SJ, Kim KJ, Kim WU, Cho CS. Interaction of mesenchymal stem cells with fibroblast-like synoviocytes via cadherin-11 promotes angiogenesis by enhanced secretion of placental growth factor. J Immunol. 2014;192(7):3003-3010.

Franzè E, Monteleone I, Laudisi F, et al. Cadherin-11 is a regulator of intestinal fibrosis. J Crohns Colitis. 2020;14(3):406-417.

Zhu Q, Wang Z, Zhou L, et al. The role of cadherin-11 in microcystin-LR-induced migration and invasion in colorectal carcinoma cells. Oncol Lett. 2018;15(2):1417-1422.

Bowler MA, Bersi MR, Ryzhova LM, Jerrell RJ, Parekh A, Merryman WD. Cadherin-11 as a regulator of valve myofibroblast mechanobiology. Am J Physiol Heart Circ Physiol. 2018;315(6):H1614-H1626.

Wu M, Pedroza M, Lafyatis R, et al. Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in systemic sclerosis. Arthritis Rheumatol. 2014;66(4):1010-1021.

Schulte JD, Srikanth M, Das S, et al. Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma. PLoS One. 2013;8(8):e70962.

Carmona FJ, Villanueva A, Vidal A, et al. Epigenetic disruption of cadherin-11 in human cancer metastasis. J Pathol. 2012;228(2):230-240.

Huang CF, Lira C, Chu K, et al. Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts. Cancer Res. 2010;70(11):4580-4589.

Pagano AF, Arc-Chagnaud C, Brioche T, Chopard A, Py G. Muscle resting and TGF-β inhibitor treatment prevent fatty infiltration following skeletal muscle injury. Cell Physiol Biochem. 2019;53(1):62-75.

Gonzalez D, Contreras O, Rebolledo DL, Espinoza JP, van Zundert B, Brandan E. ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS One. 2017;12(5):e0177649.

Phelps M, Stuelsatz P, Yablonka-Reuveni Z. Expression profile and overexpression outcome indicate a role for βKlotho in skeletal muscle fibro/adipogenesis. FEBS J. 2016;283(9):1653-1668.

Arrighi N, Moratal C, Savary G, et al. The FibromiR miR-214-3p is upregulated in Duchenne muscular dystrophy and promotes differentiation of human fibro-adipogenic muscle progenitors. Cells. 2021;10(7):1832.

Mathes S, Fahrner A, Ghoshdastider U, et al. FGF-2-dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis. Proc Natl Acad Sci U S A. 2021;118(37):e2021013118.

Lukjanenko L, Karaz S, Stuelsatz P, et al. Aging disrupts muscle stem cell function by impairing matricellular WISP1 secretion from fibro-adipogenic progenitors. Cell Stem Cell. 2019;24(3):433-446.e7.

Hu F, Lin Y, Zuo Y, Chen R, Luo S, Su Z. CCN₁ induces adipogenic differentiation of fibro/adipogenic progenitors in a chronic kidney disease model. Biochem Biophys Res Commun. 2019;520(2):385-391.

Rodgers JT, Schroeder MD, Ma C, Rando TA. HGFA is an injury-regulated systemic factor that induces the transition of stem cells into G_Alert. Cell Rep. 2017;19(3):479-486.

Contreras O. Hic1 deletion unleashes quiescent connective tissue stem cells and impairs skeletal muscle regeneration. J Cell Commun Signal. 2020;14(1):131-133.

Stumm J, Vallecillo-García P, Vom Hofe-Schneider S, et al. Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury. Stem Cell Res. 2018;32:8-16.

Xu Z, You W, Chen W, et al. Single-cell RNA sequencing and lipidomics reveal cell and lipid dynamics of fat infiltration in skeletal muscle. J Cachexia Sarcopenia Muscle. 2021;12(1):109-129.

Contreras O, Rebolledo DL, Oyarzún JE, Olguín HC, Brandan E. Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: Relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Cell Tissue Res. 2016;364(3):647-660.

Yu L, Zheng WJ, Li CQ, Ao SX, Zhou Y. miR-22-3p/KLF6/MMP14 axis in fibro-adipogenic progenitors regulates fatty infiltration in muscle degeneration. FASEB J. 2020;34(9):12691-12701.

Perdiguero E, Serrano AL, Muñoz-Cánoves P. Cilia control fat deposition during tissue repair. Dev Cell. 2017;42(2):114-116.

Hogarth MW, Defour A, Lazarski C, et al. Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B. Nat Commun. 2019;10(1):2430.

Cordani N, Pisa V, Pozzi L, Sciorati C, Clementi E. Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation. Stem Cell. 2014;32(4):874-885.

Reggio A, Spada F, Rosina M, et al. The immunosuppressant drug azathioprine restrains adipogenesis of muscle fibro/adipogenic progenitors from dystrophic mice by affecting AKT signaling. Sci Rep. 2019;9(1):4360.

Cerquone Perpetuini A, Giuliani G, Reggio A, et al. Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors. Sci Rep. 2020;10(1):5363.

Reggio A, Rosina M, Palma A, et al. Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis. Cell Death Differ. 2020;27(10):2921-2941.

Zhang H, Kim HT, Feeley BT, et al. Microenergy acoustic pulses promotes muscle regeneration through in situ activation of muscle stem cells. J Orthop Res. 2022;40(7):1621-1631.

Wosczyna MN, Perez Carbajal EE, Wagner MW, et al. Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells. Cell Stem Cell. 2021;28(7):1323-1334.e8.

Heredia JE, Mukundan L, Chen FM, et al. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013;153(2):376-388.

Kastenschmidt JM, Coulis G, Farahat PK, et al. A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression. Cell Rep. 2021;35(2):108997.

Vumbaca S, Giuliani G, Fiorentini V, et al. Characterization of the skeletal muscle secretome reveals a role for extracellular vesicles and IL1α/IL1β in restricting fibro/adipogenic progenitor adipogenesis. Biomolecules. 2021;11(8):1171.

Brioche T, Pagano AF, Py G, Chopard A. Muscle wasting and aging: experimental models, fatty infiltrations, and prevention. Mol Asp Med. 2016;50:56-87.

Kuswanto W, Burzyn D, Panduro M, et al. Poor repair of skeletal muscle in aging mice reflects a defect in local, interleukin-33-dependent accumulation of regulatory T cells. Immunity. 2016;44(2):355-367.

Madaro L, Passafaro M, Sala D, et al. Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis. Nat Cell Biol. 2018;20(8):917-927.

Faralli H, Dilworth FJ. Dystrophic muscle environment induces changes in cell plasticity. Genes Dev. 2014;28(8):809-811.

Sandonà M, Consalvi S, Tucciarone L, et al. HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells. EMBO Rep. 2020;21(9):e50863.

Saccone V, Consalvi S, Giordani L, et al. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes Dev. 2014;28(8):841-857.

Giordani L, Sandoná M, Rotini A, Puri PL, Consalvi S, Saccone V. Muscle-specific microRNAs as biomarkers of Duchenne muscular dystrophy progression and response to therapies. Rare Dis. 2014;2(1):e974969.

Consalvi S, Tucciarone L, Macrì E, et al. Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors. EMBO Rep. 2022;23(6):e54721.

Lyu X, Hu M, Peng J, Zhang X, Sanders YY. HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis. Ther Adv Chronic Dis. 2019;10:2040622319862697.

Yoon S, Kang G, Eom GH. HDAC inhibitors: therapeutic potential in fibrosis-associated human diseases. Int J Mol Sci. 2019;20(6):1329.

Liu X, Liu M, Lee L, et al. Trichostatin A regulates fibro/adipogenic progenitor adipogenesis epigenetically and reduces rotator cuff muscle fatty infiltration. J Orthop Res. 2021;39(7):1452-1462.

Biferali B, Bianconi V, Perez DF, et al. Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair. Sci Adv. 2021;7(23):eabd9371.

Barbalho SM, Prado Neto EV, De Alvares Goulart R, et al. Myokines: a descriptive review. J Sports Med Phys Fit. 2020;60(12):1583-1590.

Kang X, Yang MY, Shi YX, et al. Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors. Cell Commun Signal. 2018;16(1):42.

Welc SS, Flores I, Wehling-Henricks M, et al. Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. Nat Commun. 2019;10(1):2788.

Dong J, Dong Y, Chen Z, Mitch WE, Zhang L. The pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease. Kidney Int. 2017;91(1):119-128.

Parker E, Mendhe B, Ruan L, et al. MicroRNA cargo of extracellular vesicles released by skeletal muscle fibro-adipogenic progenitor cells is significantly altered with disuse atrophy and IL-1β deficiency. Physiol Genom. 2022;54(8):296-304.

Valero MC, Huntsman HD, Liu J, Zou K, Boppart MD. Eccentric exercise facilitates mesenchymal stem cell appearance in skeletal muscle. PLoS One. 2012;7(1):e29760.

Liu X, Zhao L, Gao Y, et al. AMP-activated protein kinase inhibition in fibro-adipogenic progenitors impairs muscle regeneration and increases fibrosis. J Cachexia Sarcopenia Muscle. 2023;14(1):479-492.

Liu L, Yue X, Sun Z, et al. Reduction of senescent fibro-adipogenic progenitors in progeria-aged muscle by senolytics rescues the function of muscle stem cells. J Cachexia Sarcopenia Muscle. 2022;13(6):3137-3148.

Moiseeva V, Cisneros A, Sica V, et al. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature. 2023;613(7942):169-178.

Yamakawa D, Tsuboi J, Kasahara K, et al. Cilia-mediated insulin/Akt and ST2/JNK signaling pathways regulate the recovery of muscle injury. Adv Sci. 2022;10(1):e2202632.

Yao L, Tichy ED, Zhong L, et al. Gli1 defines a subset of fibro-adipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation. J Bone Miner Res. 2021;36(6):1159-1173.

Jia G, Sowers JR. Increased fibro-adipogenic progenitors and intramyocellular lipid accumulation in obesity-related skeletal muscle dysfunction. Diabetes. 2019;68(1):18-20.

Buras ED, Converso-Baran K, Davis CS, et al. Fibro-adipogenic remodeling of the diaphragm in obesity-associated respiratory dysfunction. Diabetes. 2019;68(1):45-56.

Reggio A, Rosina M, Krahmer N, et al. Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration. Life Sci Alliance. 2020;3(3):e202000646.

Mogi M, Kohara K, Nakaoka H, et al. Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation. J Cachexia Sarcopenia Muscle. 2016;7(2):213-224.

D'Souza D, Roubos S, Larkin J, et al. The late effects of radiation therapy on skeletal muscle morphology and progenitor cell content are influenced by diet-induced obesity and exercise training in male mice. Sci Rep. 2019;9(1):6691.

Pérez-Díaz S, Koumaiha Z, Borok MJ, et al. Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors. Matrix Biol. 2022;112:90-115.

Marinkovic M, Fuoco C, Sacco F, et al. Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis. Life Sci Alliance. 2019;2(3):e201900437.

Moratal C, Arrighi N, Dechesne CA, Dani C. Control of muscle fibro-adipogenic progenitors by myogenic lineage is altered in aging and Duchenne muscular dystrophy. Cell Physiol Biochem. 2019;53(6):1029-1045.

Pagano AF, Brioche T, Arc-Chagnaud C, Demangel R, Chopard A, Py G. Short-term disuse promotes fatty acid infiltration into skeletal muscle. J Cachexia Sarcopenia Muscle. 2018;9(2):335-347.

Pagano AF, Demangel R, Brioche T, et al. Muscle regeneration with intermuscular adipose tissue (IMAT) accumulation is modulated by mechanical constraints. PLoS One. 2015;10(12):e0144230.

De Lisio M, Jensen T, Sukiennik RA, Huntsman HD, Boppart MD. Substrate and strain alter the muscle-derived mesenchymal stem cell secretome to promote myogenesis. Stem Cell Res Ther. 2014;5(3):74.

Kaneshige A, Kaji T, Zhang L, et al. Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load. Cell Stem Cell. 2022;29(2):265-280.e6.

Schüler SC, Kirkpatrick JM, Schmidt M, et al. Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality. Cell Rep. 2021;35(10):109223.

Lees-Shepard JB, Stoessel SJ, Chandler JT, et al. An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice. J Clin Investig. 2022;132(12):e153795.

Yamamoto M, Stoessel SJ, Yamamoto S, Goldhamer DJ. Overexpression of wild-type ACVR1 in fibrodysplasia ossificans progressiva mice rescues perinatal lethality and inhibits heterotopic ossification. J Bone Miner Res. 2022;37(11):2077-2093.

Lees-Shepard JB, Nicholas SAE, Stoessel SJ, et al. Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity. eLife. 2018;7:e40814.

Stanley A, Tichy ED, Kocan J, Roberts DW, Shore EM, Mourkioti F. Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva. NPJ Regen Med. 2022;7(1):5.

Contreras O, Villarreal M, Brandan E. Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Skelet Muscle. 2018;8(1):5.

Davies MR, Liu X, Lee L, et al. TGF-β small molecule inhibitor SB431542 reduces rotator cuff muscle fibrosis and fatty infiltration by promoting fibro/adipogenic progenitor apoptosis. PLoS One. 2016;11(5):e0155486.

Lee C, Liu M, Agha O, Kim HT, Liu X, Feeley BT. Beige fibro-adipogenic progenitor transplantation reduces muscle degeneration and improves function in a mouse model of delayed repair of rotator cuff tears. J Shoulder Elb Surg. 2020;29(4):719-727.

Lee C, Liu M, Agha O, Kim HT, Feeley BT, Liu X. Beige FAPs transplantation improves muscle quality and shoulder function after massive rotator cuff tears. J Orthop Res. 2020;38(5):1159-1166.

Ancel S, Mashinchian O, Feige JN. Adipogenic progenitors keep muscle stem cells young. Aging. 2019;11(18):7331-7333.

Pagé M, Maheux C, Langlois A, et al. CD34 regulates the skeletal muscle response to hypoxia. J Muscle Res Cell Motil. 2019;40(3–4):309-318.

Alfaro LAS, Dick SA, Siegel AL, et al. CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Stem Cell. 2011;29(12):2030-2041.

Yang S, Yang J, Zhao H, et al. The protective effects of γ-tocotrienol on muscle stem cells through inhibiting reactive oxidative stress production. Front Cell Dev Biol. 2022;10:820520.

Berry R, Rodeheffer MS. Characterization of the adipocyte cellular lineage in vivo. Nat Cell Biol. 2013;15(3):302-308.

Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells in vivo. Cell. 2008;135(2):240-249.

Schwalie PC, Dong H, Zachara M, et al. A stromal cell population that inhibits adipogenesis in mammalian fat depots. Nature. 2018;559(7712):103-108.

Cattaneo P, Mukherjee D, Spinozzi S, et al. Parallel lineage-tracing studies establish fibroblasts as the prevailing in vivo adipocyte progenitor. Cell Rep. 2020;30(2):571-582.e2.

Lemos DR, Paylor B, Chang C, Sampaio A, Underhill TM, Rossi FMV. Functionally convergent white adipogenic progenitors of different lineages participate in a diffused system supporting tissue regeneration. Stem Cell. 2012;30(6):1152-1162.

Marcelin G, Ferreira A, Liu Y, et al. A PDGFRα-mediated switch toward CD9^high adipocyte progenitors controls obesity-induced adipose tissue fibrosis. Cell Metab. 2017;25(3):673-685.

Merrick D, Sakers A, Irgebay Z, et al. Identification of a mesenchymal progenitor cell hierarchy in adipose tissue. Science. 2019;364(6438):eaav2501.

Gao Z, Daquinag AC, Su F, Snyder B, Kolonin MG. PDGFRα/PDGFRβ signaling balance modulates progenitor cell differentiation into white and beige adipocytes. Development. 2018;145(1):dev155861.

Iwayama T, Steele C, Yao L, et al. PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev. 2015;29(11):1106-1119.

Rivera-Gonzalez GC, Shook BA, Andrae J, et al. Skin adipocyte stem cell self-renewal is regulated by a PDGFA/AKT-signaling axis. Cell Stem Cell. 2016;19(6):738-751.

Hilgendorf KI, Johnson CT, Mezger A, et al. Omega-3 fatty acids activate ciliary FFAR4 to control adipogenesis. Cell. 2019;179(6):1289-1305.e21.

Marcelin G, Da Cunha C, Gamblin C, et al. Autophagy inhibition blunts PDGFRA adipose progenitors' cell-autonomous fibrogenic response to high-fat diet. Autophagy. 2020;16(12):2156-2166.

Tang J, Wang H, Huang X, et al. Arterial Sca1⁺ vascular stem cells generate de novo smooth muscle for artery repair and regeneration. Cell Stem Cell. 2020;26(1):81-96.e4.

Kim BJ, Kim YH, Lee YA, et al. Platelet-derived growth factor receptor-alpha positive cardiac progenitor cells derived from multipotent germline stem cells are capable of cardiomyogenesis in vitro and in vivo. Oncotarget. 2017;8(18):29643-29656.

Chong JJH, Chandrakanthan V, Xaymardan M, et al. Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell. 2011;9(6):527-540.

Noseda M, Harada M, McSweeney S, et al. PDGFRα demarcates the cardiogenic clonogenic Sca1⁺ stem/progenitor cell in adult murine myocardium. Nat Commun. 2015;6:6930.

Chen G, Bracamonte-Baran W, Diny NL, et al. Sca-1⁺ cardiac fibroblasts promote development of heart failure. Eur J Immunol. 2018;48(9):1522-1538.

Lombardi R, Chen SN, Ruggiero A, et al. Cardiac fibro-adipocyte progenitors express desmosome proteins and preferentially differentiate to adipocytes upon deletion of the desmoplakin gene. Circ Res. 2016;119(1):41-54.

Endale M, Ahlfeld S, Bao E, et al. Temporal, spatial, and phenotypical changes of PDGFRα expressing fibroblasts during late lung development. Dev Biol. 2017;425(2):161-175.

Soliman H, Paylor B, Scott RW, et al. Pathogenic potential of Hic1-expressing cardiac stromal progenitors. Cell Stem Cell. 2020;26(3):459-461.

Suffee N, Moore-Morris T, Jagla B, et al. Reactivation of the epicardium at the origin of myocardial fibro-fatty infiltration during the atrial cardiomyopathy. Circ Res. 2020;126(10):1330-1342.

McQualter JL, Brouard N, Williams B, et al. Endogenous fibroblastic progenitor cells in the adult mouse lung are highly enriched in the Sca-1 positive cell fraction. Stem Cell. 2009;27(3):623-633.

Li R, Bernau K, Sandbo N, Gu J, Preissl S, Sun X. Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response. eLife. 2018;7:e36865.

Zepp JA, Zacharias WJ, Frank DB, et al. Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung. Cell. 2017;170(6):1134-1148.e10.

Conti P, Ronconi G, Caraffa A, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2):anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020;34(2):327-331.

Tale S, Ghosh S, Meitei SP, Kolli M, Garbhapu AK, Pudi S. Post-COVID-19 pneumonia pulmonary fibrosis. QJM. 2020;113(11):837-838.

Vasarmidi E, Tsitoura E, Spandidos DA, Tzanakis N, Antoniou KM. Pulmonary fibrosis in the aftermath of the COVID-19 era (Review). Exp Ther Med. 2020;20(3):2557-2560.

Fraser E. Long term respiratory complications of covid-19. BMJ. 2020;370:m3001.

Yen BL, Yen ML, Wang LT, Liu KJ, Sytwu HK. Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: gleaning insights for possible use in COVID-19. Stem Cells Transl Med. 2020;9(10):1163-1173.

Wang XY. MSCs transplantation may be a potential therapeutic strategy for COVID-19 treatment. Eur Rev Med Pharmacol Sci. 2020;24(8):4537-4538.

Houlihan DD, Mabuchi Y, Morikawa S, et al. Isolation of mouse mesenchymal stem cells on the basis of expression of Sca-1 and PDGFR-Α. Nat Protoc. 2012;7(12):2103-2111.

Mashimo T, Sato Y, Akita D, et al. Bone marrow-derived mesenchymal stem cells enhance bone marrow regeneration in dental extraction sockets. J Oral Sci. 2019;61(2):284-293.

Goto T, Miyagawa S, Tamai K, et al. High-mobility group box 1 fragment suppresses adverse post-infarction remodeling by recruiting PDGFRα-positive bone marrow cells. PLoS One. 2020;15(4):e0230392.

Yang X, Chen J, Wang J, et al. Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis. Immunity. 2022;55(7):1185-1199.e8.

Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Investig. 2007;117(1):50-59.

Bachem MG, Schneider E, Gross H, et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 1998;115(2):421-432.

Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 1998;43(1):128-133.

Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut. 2002;50(4):535-541.

Zheng M, Li H, Sun L, Brigstock DR, Gao R. Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway. Cytokine. 2021;143:155536.

Jiang W, Jin L, Ju D, et al. The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction. Sci Transl Med. 2022;14(664):eabn3586.

Ng B, Viswanathan S, Widjaja AA, et al. IL11 activates pancreatic stellate cells and causes pancreatic inflammation, fibrosis and atrophy in a mouse model of pancreatitis. Int J Mol Sci. 2022;23(7):3549.

Zhang T, Zhang G, Yang W, et al. Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis. Cell Death Dis. 2021;12(11):996.

Li L, Wang G, Hu JS, et al. RB₁CC₁-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis. Cell Death Dis. 2018;9(10):952.

Ren Y, Cui Q, Zhang J, et al. Milk fat globule-EGF factor 8 alleviates pancreatic fibrosis by inhibiting ER stress-induced chaperone-mediated autophagy in mice. Front Pharmacol. 2021;12:707259.

Rickmann M, Vaquero EC, Malagelada JR, Molero X. Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology. 2007;132(7):2518-2532.

Vonlaufen A, Xu Z, Daniel B, et al. Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model. Gastroenterology. 2007;133(4):1293-1303.

Vonlaufen A, Phillips PA, Xu Z, et al. Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats. Gut. 2011;60(2):238-246.

Xue J, Zhao Q, Sharma V, et al. Aryl hydrocarbon receptor ligands in cigarette smoke induce production of interleukin-22 to promote pancreatic fibrosis in models of chronic pancreatitis. Gastroenterology. 2016;151(6):1206-1217.

Li Z, Lu D, Jin T, Liu X, Hao J. Nicotine facilitates pancreatic fibrosis by promoting activation of pancreatic stellate cells via α7nAChR-mediated JAK2/STAT3 signaling pathway in rats. Toxicol Lett. 2021;349:84-91.

Xia D, Halder B, Godoy C, et al. NADPH oxidase 1 mediates caerulein-induced pancreatic fibrosis in chronic pancreatitis. Free Radic Biol Med. 2020;147:139-149.

Li M, Yuan Y, Han X, Liu X, Zhang W, Hao J. Antioxidant mitoquinone alleviates chronic pancreatitis via anti-fibrotic and antioxidant effects. J Inflamm Res. 2022;15:4409-4420.

Li F, Wang M, Li X, et al. Inflammatory-miR-301a circuitry drives mTOR and Stat3-dependent PSC activation in chronic pancreatitis and PanIN. Mol Ther Nucleic Acids. 2022;27:970-982.

Wang Q, Wang H, Jing Q, et al. Regulation of pancreatic fibrosis by acinar cell-derived exosomal miR-130a-3p via targeting of stellate cell PPAR-Γ. J Inflamm Res. 2021;14:461-477.