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Rapid Communication | Open Access

Constitutive androstane receptor: A tumor suppressor and a biomarker for favorable prognosis of liver diseases

Sarah Da Won BaeaRomario NguyenaLawrence YuenbVincent LambJacob Georgea( )Liang Qiaoa( )
Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney, and Westmead Hospital, Westmead, NSW 2145, Australia
Department of Surgery, Westmead Hospital, Westmead, NSW 2145, Australia

Peer review under responsibility of Chongqing Medical University.

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References

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Baes M, Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol. 1994;14(3):1544–1552.

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Bae SDW, Nguyen R, Qiao L, George J. Role of the constitutive androstane receptor (CAR) in human liver cancer. Biochim Biophys Acta Rev Cancer. 2021;1875(2):188516.

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Chakraborty S, Kanakasabai S, Bright JJ. Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells. Br J Cancer. 2011;104(3):448–459.

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Li Z, Kwon SM, Li D, et al. Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling. J Biol Chem. 2022;298(5):101885.

Genes & Diseases
Article number: 101198
Cite this article:
Da Won Bae S, Nguyen R, Yuen L, et al. Constitutive androstane receptor: A tumor suppressor and a biomarker for favorable prognosis of liver diseases. Genes & Diseases, 2024, 11(6): 101198. https://doi.org/10.1016/j.gendis.2023.101198

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Received: 19 August 2023
Published: 19 December 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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