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Rapid Communication | Open Access

Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia

Fei Aoa,b,1Fan Chena,1Minhong Lva,1Yuming CaobJinfeng XubJingbo XucAnskar Yu-Hung LeungdQiwen Yuanb( )Li Wangb( )Bailiang Hea( )
Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China
Department of Gynecology and Obstetrics, Perinatal Medical Center, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China
Department of Hematology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China
Division of Haematology, Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

1

Makishima H, Yoshida K, Nguyen N, et al. Somatic SETBP1 mutations in myeloid malignancies. Nat Genet. 2013;45(8):942–946.

2

He BL, Shi X, Man CH, et al. Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia. Blood. 2014;123(16):2518–2529.

3

Pacharne S, Dovey OM, Cooper JL, et al. SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML. Blood Adv. 2021;5(9):2412–2425.

4

Li K, Du Y, Cai Y, et al. Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia. Leukemia. 2023;37(2):308–325.

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Tanaka A, Nishimura K, Saika W, et al. SETBP1 is dispensable for normal and malignant hematopoiesis. Leukemia. 2023;37(9):1802–1811.

Genes & Diseases
Article number: 101195
Cite this article:
Ao F, Chen F, Lv M, et al. Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia. Genes & Diseases, 2024, 11(6): 101195. https://doi.org/10.1016/j.gendis.2023.101195

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Received: 21 June 2023
Published: 13 December 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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