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Rapid Communication | Open Access

RNA binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma metastasis by regulating Slug mRNA stability

Yao Liua,1Huan Fenga,1Qi ZhaoaXiao LiangaYing WangaShuai Xiaob( )Suqin Shena( )Jiaxue Wua( )
State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Shanghai 200438, China
The First Affiliated Hospital, Cancer Research Institute, Department of Gastrointestinal Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China

1 These authors contributed equally to this work and shared the co-first authorship.

Peer review under responsibility of Chongqing Medical University.

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References

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Hentze MW, Castello A, Schwarzl T, Preiss T. A brave new world of RNA-binding proteins. Nat Rev Mol Cell Biol. 2018;19(5):327–341.

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Pereira B, Billaud M, Almeida R. RNA-binding proteins in cancer: old players and new actors. Trends Cancer. 2017;3(7):506–528.

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Feng H, Liu J, Qiu Y, et al. RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression. Oncogene. 2020;39(33):5495–5506.

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Hotz B, Arndt M, Dullat S, Bhargava S, Buhr HJ, Hotz HG. Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer. Clin Cancer Res. 2007;13(16):4769–4776.

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Zhao J, Xu H, Su Y, et al. Emerging regulatory mechanisms of N6-methyladenosine modification in cancer metastasis. Phenomics. 2023;3(1):83–100.

Genes & Diseases
Article number: 101192
Cite this article:
Liu Y, Feng H, Zhao Q, et al. RNA binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma metastasis by regulating Slug mRNA stability. Genes & Diseases, 2024, 11(6): 101192. https://doi.org/10.1016/j.gendis.2023.101192

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Received: 21 June 2023
Published: 14 December 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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