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Rapid Communication | Open Access

Simultaneous detection of methylation and genetic variations of BCR-ABL1 gene by nanopore Cas9-targeted sequencing

Shuilian Xiea,1Ying Yanga,1Junjie Zhanga,1Menglin ZhuaWang LiaMengting LiaYijian ChenbHailiang LibWeidan LuncWeelic ChongdShaogui Wana( )
Center for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi 341000, China
Department of Hematology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, China
Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, China
Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA

1 These authors have contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

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Ali MAM. Chronic myeloid leukemia in the era of tyrosine kinase inhibitors: An evolving paradigm of molecularly targeted therapy. Mol Diagn Ther. 2016;20(4):315–333.

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Alves R, Gonçalves AC, Rutella S, et al. Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia-from molecular mechanisms to clinical relevance. Cancers. 2021;13(19):4820.

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Koh Y, Kim DY, Park SH, et al. Increased BCR promoter DNA methylation status strongly correlates with favorable response to imatinib in chronic myeloid leukemia patients. Oncol Lett. 2011;2(1):181–187.

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Gilpatrick T, Lee I, Graham JE, et al. Targeted nanopore sequencing with Cas9-guided adapter ligation. Nat Biotechnol. 2020;38(4):433–438.

Genes & Diseases
Article number: 101190
Cite this article:
Xie S, Yang Y, Zhang J, et al. Simultaneous detection of methylation and genetic variations of BCR-ABL1 gene by nanopore Cas9-targeted sequencing. Genes & Diseases, 2024, 11(6): 101190. https://doi.org/10.1016/j.gendis.2023.101190

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Received: 19 August 2023
Published: 06 December 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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