AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
PDF (1.4 MB)
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Rapid Communication | Open Access

The silencing transcription factor REST targets UCHL1 to regulate inflammatory response and fibrosis during cardiac hypertrophy

Wenze Caoa,b,c,1Huan Liua,b,c,1Ye Xua,b,cSangyu Hua,b,cYujie Yanga,b,c,dLi Lia,b,c,d,e( )Luying Penga,b,c,d,e( )
State Key Laboratory of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Institute of Medical Genetics, Tongji University, Shanghai 200092, China
Heart Health Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Department of Medical Genetics, Tongji University School of Medicine, Shanghai 200092, China
Research Units of Origin and Regulation of Heart Rhythm, Chinese Academy of Medical Sciences, Beijing 100730, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

Show Author Information

References

1

Inazumi H, Kuwahara K. NRSF/REST-mediated epigenomic regulation in the heart: transcriptional control of natriuretic peptides and beyond. Biology. 2022;11(8):1197.

2

Inazumi H, Kuwahara K, Nakagawa Y, et al. NRSF- GNAO1 pathway contributes to the regulation of cardiac Ca2+ homeostasis. Circ Res. 2022;130(2):234–248.

3

Barrachina M, Moreno J, Juvés S, Moreno D, Olivé M, Ferrer I. Target genes of neuron-restrictive silencer factor are abnormally up-regulated in human myotilinopathy. Am J Pathol. 2007;171(4):1312–1323.

4

Bi HL, Zhang XL, Zhang YL, et al. The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. Sci Adv. 2020;6(16):eaax4826.

5

Li H, Liu Z, Wu Y, et al. The deficiency of NRSF/REST enhances the pro-inflammatory function of astrocytes in a model of Parkinson’s disease. Biochim Biophys Acta, Mol Basis Dis. 2020;1866(1):165590.

Genes & Diseases
Article number: 101183
Cite this article:
Cao W, Liu H, Xu Y, et al. The silencing transcription factor REST targets UCHL1 to regulate inflammatory response and fibrosis during cardiac hypertrophy. Genes & Diseases, 2024, 11(6): 101183. https://doi.org/10.1016/j.gendis.2023.101183

57

Views

2

Downloads

0

Crossref

0

Web of Science

0

Scopus

0

CSCD

Altmetrics

Received: 31 August 2023
Published: 25 November 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Return