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Rapid Communication | Open Access

Adeno-associated virus-mediated intraprostatic suppression of MIR375 inhibits tumor progression in the TRAMP mouse model of prostate cancer

Xianyanling Yi1Jin Li1Zeyu Han1Tianyi ZhangDazhou LiaoJia YouJianzhong Ai( )
Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

1 These authors contributed equally to this work and shared the first authorship.

Peer review under responsibility of Chongqing Medical University.

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References

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Mukherji D, Omlin A, Pezaro C, Shamseddine A, de Bono J. Metastatic castration-resistant prostate cancer (CRPC): Preclinical and clinical evidence for the sequential use of novel therapeutics. Cancer Metastasis Rev. 2014;33(2):555-566.

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Gan J, Liu S, Zhang Y, et al. microRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis. Exp Mol Med. 2022;54(8):1290-1305.

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Ai J, Wang D, Wei Q, Li H, Gao G. Adeno-associated virus serotype vectors efficiently transduce normal prostate tissue and prostate cancer cells. Eur Urol. 2016;69(1):179-181.

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Huang X, Yuan T, Liang M, et al. Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. Eur Urol. 2015;67(1):33-41.

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Tanikawa C, Nakagawa H, Furukawa Y, Nakamura Y, Matsuda K. CLCA2 as a p53-inducible senescence mediator. Neoplasia. 2012;14(2):141-149.

Genes & Diseases
Article number: 101182
Cite this article:
Yi X, Li J, Han Z, et al. Adeno-associated virus-mediated intraprostatic suppression of MIR375 inhibits tumor progression in the TRAMP mouse model of prostate cancer. Genes & Diseases, 2024, 11(6): 101182. https://doi.org/10.1016/j.gendis.2023.101182

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Received: 12 June 2023
Published: 23 November 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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