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Rapid Communication | Open Access

Loss of homeostatic functions in microglia from a murine model of Friedreich’s ataxia

Ilaria Della Vallea,b,1Martina Milania,b,1Simona Rossic,dRiccardo TurchiaFlavia TortoliciaValentina Nescid,eAlberto Ferric,dCristiana Vallec,dDaniele Lettieri-Barbatoa,dKatia AquilanoaMauro CozzolinocSavina Apollonia( )Nadia D’Ambrosia( )
Department of Biology, University of Rome Tor Vergata, Rome 00133, Italy
PhD Program in Cellular and Molecular Biology, University of Rome Tor Vergata, Rome 00133, Italy
Institute of Translational Pharmacology, National Research Council (CNR), Rome 00133, Italy
Santa Lucia Foundation IRCCS, Rome 00179, Italy
Department of Systems Medicine, “Tor Vergata” University of Rome, Rome 00133, Italy

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

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Bürk K. Friedreich Ataxia: current status and future prospects. Cerebellum Ataxias. 2017;4:4.

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Li Q, Barres BA. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol. 2018;18(4):225-242.

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Apolloni S, Milani M, D’Ambrosi N. Neuroinflammation in Friedreich’s ataxia. Int J Mol Sci. 2022;23(11):6297.

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Khan W, Corben LA, Bilal H, et al. Neuroinflammation in the cerebellum and brainstem in Friedreich ataxia: An [18F]-FEMPA PET study. Mov Disord. 2022;37(1):218-224.

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Afridi R, Lee WH, Suk K. Microglia gone awry: linking immunometabolism to neurodegeneration. Front Cell Neurosci. 2020;14:246.

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Lin H, Magrane J, Clark EM, et al. Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia. Dis Model Mech. 2017;10(12):1529-1538.

Genes & Diseases
Article number: 101178
Cite this article:
Valle ID, Milani M, Rossi S, et al. Loss of homeostatic functions in microglia from a murine model of Friedreich’s ataxia. Genes & Diseases, 2024, 11(6): 101178. https://doi.org/10.1016/j.gendis.2023.101178

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Received: 10 July 2023
Published: 23 November 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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