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Rapid Communication | Open Access

PDLIM1 sustains DNA damage response by promoting chromatin relaxation and activating DNA–PK complex

Yue Langa,c,1( ), Dexuan Gaod,1, Lan Yuf,1, Xiang-Xiang Zhangc, Debabrata Sahae, Benjamin P.C. Chene, Meng-Meng Gub,c( ), Zeng-Fu Shangc,e( )
Department of Nuclear Medicine, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China
Department of Nuclear Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215002, China
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China
Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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Genes & Diseases
Volume 11 Issue 6,
November 2024
Article number: 101139
DOI: 10.1016/j.gendis.2023.101139
Cite this article:
Lang Y, Gao D, Yu L, et al. PDLIM1 sustains DNA damage response by promoting chromatin relaxation and activating DNA–PK complex. Genes & Diseases, 2024, 11(6): 101139. https://doi.org/10.1016/j.gendis.2023.101139

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Received: 04 June 2023
Published: 13 October 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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