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Review Article | Open Access

Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

Feifei Pua,1, Fengxia Chenb,c,1, Zhicai Zhanga, Deyao Shia,e, Binlong Zhonga, Xiao Lva,d, Andrew Blake Tuckere, Jiaming Fane,f, Alexander J. Lie, Kevin Qine, Daniel Hue, Connie Chene, Hao Wange,f, Fang Hee,g, Na Nie,f, Linjuan Huange,g, Qing Liue,h, William Wagstaffe, Hue H. Luue, Rex C. Haydone, Le Shene,i, Tong-Chuan Hee,i, Jianxiang Liua( ), Zengwu Shaoa( )
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China
Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, PR China
Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, PR China
Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD 21205, USA
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA
Ministry of Education Key Laboratory of Diagnostic Medicine, Department of Clinical Biochemistry, School of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, PR China
Departments of Nephrology, and Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China
Department of Spine Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China
Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

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Abstract

The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy. Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells. Anti-tumor drugs were developed to induce apoptosis, but some patient's show apoptosis escape and chemotherapy resistance. Therefore, other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment. Ferroptosis is a newly discovered iron-dependent, non-apoptotic type of cell death that is highly negatively correlated with cancer development. Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis. This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment.

Keywords

CancerCancer therapyClinical applicationFerroptosisLipid peroxidationPathogenesis

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Genes & Diseases
Volume 9 Issue 2,
March 2022
Pages 347-357
DOI: 10.1016/j.gendis.2020.11.019

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Cite this article:
Pu F, Chen F, Zhang Z, et al. Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer. Genes & Diseases, 2022, 9(2): 347-357. https://doi.org/10.1016/j.gendis.2020.11.019

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Received: 09 October 2020
Revised: 23 November 2020
Accepted: 26 November 2020
Published: 04 December 2020
© 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).