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Lysine succinylation (Ksucc), defined as a transfer of a succinyl group to a lysine residue of a protein, is a newly identified protein post-translational modification1–3. This chemical modification is reversible, dynamic, and evolutionarily conserved 4 where it has been comprehensively studied in both bacterial and mammalian cells5–7. Numerous proteins involved in the regulation of various cellular and biological processes have been shown to be heavily succinylated5–7. Emerging clinical data provides evidence that dysregulation of Ksucc is correlated with the development of several diseases, including cardiovascular diseases and cancer7–9. Therefore, an in-depth understanding of Ksucc and its regulation is important not only for understanding its physiological function but also for developing drug therapies and targeted agents for these diseases. In this review, we highlight some of the recent advances in understanding the role of Ksucc and desuccinylation under physiological and pathological conditions.

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Publication history

Received: 28 February 2019
Revised: 11 September 2019
Accepted: 27 September 2019
Published: 08 October 2019
Issue date: June 2020

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© 2019, Chongqing Medical University.

Acknowledgements

Acknowledgements

We apologize to any authors whose work could not be included owing to space limitations. This work was supported in part by NIH R01 CA225680-01 (T.H.), Research Scholar Grant (RSG-19-076-01-TBE) from the American Cancer Society (T.H.), Career Catalyst Research funding (CCR14300798) from the Susan G. Komen Foundation (T.H.), the Eagles Cancer Research Fund (T.H.), a Team Science Platform Award from the Mayo Clinic Center for Biomedical Discovery (T.H.), the Developmental Therapeutics Program from the Mayo Clinic Cancer Center (T.H.), and the Mayo Clinic Breast SPORE P50CA 116201-10 (T.H.). E.K.W. was supported by a predoctoral fellowship from the Mayo Foundation for Education and Research.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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