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Review Article | Open Access

Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review

Feixuan Wanga,b, Jingqiong Wana, Yangzhen Liaoc, Shangyu Liua, Yuan Weia, Zhen Ouyanga( )
School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
Nanjing Institute of Product Quality Inspection, Nanjing 210019, China
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Brain energy homeostasis is a vital physiological function in maintaining a balanced internal metabolic environment. The impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolic disorders and related neurodegenerative diseases. Dendrobium species (‘Shihu’ in Chinese) such as D. officinale, D. huoshanense, D. nobile, D. chrysanthum, D. loddigesii, D. moniliforme, D. gratiosissimum, D. candidum and D. caulis are widely used as traditional Chinese medicines/nutraceuticals to control and treat neurodegenerative disorders. These dietary herbs and their derived compounds possess a variety of biological properties, such as suppression of oxidative stress and neuroinflammation, regulation of energy homeostasis mainly through improving brain mitochondria function, insulin signaling and lipid metabolism. Furthermore, they reduce neurotoxicity, alleviate brain injury and neuropathy, and prevent neurodegenerative conditions including stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease in humans and/or rodents. Moreover, the nutraceuticals from Dendrobium species promote gut health and aid digestion, which appear to be associated with beneficial effects on brain energy homeostasis. Based on the above-mentioned health benefits associated with Dendrobium species, this work reviews their nutraceutical role in neurodegenerative disorders and further suggests the need to elucidate mechanisms of the underlying molecular actions.

Keywords

Dendrobium speciesNutraceutical roleEnergy homeostasisNeurodegenerative diseases

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Food Science and Human Wellness
Volume 12 Issue 6,
November 2023
Pages 2151-2174
DOI: 10.1016/j.fshw.2023.03.029
Cite this article:
Wang F, Wan J, Liao Y, et al. Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review. Food Science and Human Wellness, 2023, 12(6): 2151-2174. https://doi.org/10.1016/j.fshw.2023.03.029

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Received: 12 April 2022
Revised: 17 May 2022
Accepted: 15 June 2022
Published: 04 April 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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