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Review Article | Open Access

Effects of probiotics and its fermented milk on constipation: a systematic review

Jiaming Yana,b,1, Meiling Wua,b,1, Wei Zhaoa,b, Lai-Yu Kwoka,b, Wenyi Zhanga,b( )
Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China
Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University, Hohhot 010018, China

1 The authors contributed equally to this article.

Peer review under responsibility of KeAi Communications Co., Ltd.

Show Author Information

Abstract

This study reviewed clinical evidence of probiotics-mediated effects on constipation. Four databases were used in the literature searches, namely Cochrane Library, Embase, Pubmed, and Web of Science. The last retrieval time was March 2021. Collected data were analyzed by Review Manager (version 5.3) and Stata (version 14). The primary search retrieved 8418 articles after removing duplicates. Eventually, 26 studies were included in the meta-analysis. Administration of probiotics significantly increased stool frequency (MD: 1.15 times/week; 95% CI: 0.59 to 1.70; P < 0.0001), improved bloating (MD: –0.48; 95% CI: –0.89 to –0.07; P = 0.02), reduced abdominal pain (MD: –0.71; 95% CI: –1.25 to –0.16; P = 0.01), and improved quality of life (MD: –0.73; 95% CI: –1.37 to –0.10; P = 0.02). However, the clinical effect of intake of probiotics on stool consistency was non-significant (MD: 0.07; 95% CI: –0.34 to 0.48; P = 0.73). Based on our analysis, probiotic supplements were effective in relieving constipation through symptom improvement. The effectiveness of dosage forms of intervention ranked: capsules > others (tablets, powder) > fermented milk.

Keywords

ConstipationProbioticsFermented milkMeta-analysisDosage form

References

[1]

B.V. Kumar, S.V.N. Vijayendra, O.V.S. Reddy, Trends in dairy and non-dairy probiotic products: a review, J. Food Sci. Technol. 52 (2015) 6112-6124. https://doi.org/10.1007/s13197-015-1795-2.
Crossref Google Scholar
[2]

X.Y. Bai, L.L. Shen, X. Gao, et al., Differential structures and enterotype-like clusters of Bifidobacterium responses to probiotic fermented milk consumption across subjects using a Bifidobacterium-target procedure, Food Res. Int. 140 (2021) 109839. https://doi.org/10.1016/j.foodres.2020.109839.
Crossref Google Scholar
[3]

G.Q. Yao, Q.W. He, W.Y. Zhang, et al., Single molecule, real-time sequencing technology improves the sensitivity for detecting bacteria in koumiss, a traditional fermented mare milk product, Sci. Bull. 65(24) (2020) 2065-2067. https://doi.org/10.1016/j.scib.2020.07.028.
Crossref Google Scholar
[4]

M. Zommiti, M.G.J. Feuilloley, N. Connil, Update of probiotics in human world: a nonstop source of benefactions till the end of time, Microorganisms 8(12) (2020) 1907. https://doi.org/10.3390/microorganisms8121907.
Crossref Google Scholar
[5]

S. Klayraung, H. Viernstein, S. Okonogi, Development of tablets containing probiotics: effects of formulation and processing parameters on bacterial viability, Int. J. Pharm. 370 (2009) 54-60. https://doi.org/10.1016/j.ijpharm.2008.11.004.
Crossref Google Scholar
[6]

J. Buttriss, Nutritional properties of fermented milk products, Int. J. Dairy Technol. 50 (1997) 21-27. https://doi.org/10.1111/j.1471-0307.1997.tb01731.x.
Crossref Google Scholar
[7]

E.M. Ha, The impact of gut microbiota in human health and diseases: implication for therapeutic potential, Biomol. Ther. 19 (2011) 155-173. https://doi.org/10.4062/biomolther.2011.19.2.155.
Crossref Google Scholar
[8]

L.V. McFarland, Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: a systematic review, BMJ Open. 4 (2014) e005047. https://doi.org/10.1136/bmjopen-2014-005047.
Crossref Google Scholar
[9]

M.L. Ritchie, T.N. Romanuk, A meta-analysis of probiotic efficacy for gastrointestinal diseases, PLoS One 7 (2012) e34938. https://doi.org/10.1371/journal.pone.0034938.
Crossref Google Scholar
[10]

A. Tamime, Fermented milks: a historical food with modern applications - a review, Eur. J. Clin. Nutr. 56 (2002) S2-S15. https://doi.org/10.1038/sj.ejcn.1601657.
Crossref Google Scholar
[11]

H.A. Sakandar, H.P. Zhang, Trends in Probiotic(s)-ermented milks and their in vivo functionality: a review, Trends Food Sci. Technol. 110 (2021) 55-65. https://doi.org/10.1016/j.tifs.2021.01.054.
Crossref Google Scholar
[12]

Y.Z. Yue, X.P. Wang, H.J. Yang, et al., Clinical efficacy of the traditional Chinese herbal formula, (tong bian decoction) on laxative dependence constipation in elderly persons: a randomized, multicenter, controlled trial, Eur. J. Integr. Med. 24 (2018) 23-29. https://doi.org/10.1016/j.eujim.2018.10.010.
Crossref Google Scholar
[13]

K. Airaksinen, N. Yeung, A. Lyra, et al., The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial, Benef. Microbes. 10 (2019) 617-627. https://doi.org/10.3920/BM2018.0163.
Crossref Google Scholar
[14]

I.L. Khalif, E.M. Quigley, E.A. Konovitch, et al., Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation, Dig. Liver Dis. 37 (2005) 838-849. https://doi.org/10.1016/j.dld.2005.06.008.
Crossref Google Scholar
[15]

E. Dimidi, S. Christodoulides, S.M. Scott, et al., Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation, Adv. Nutr. 8 (2017) 484-494. https://doi.org/10.3945/an.116.014407.
Crossref Google Scholar
[16]

C. Dennison, M. Prasad, A. Lloyd, et al.,The health-related quality of life and economic burden of constipation, Pharmacoeconomics 23 (2005) 461-476. https://doi.org/10.2165/00019053-200523050-00006.
Crossref Google Scholar
[17]

S. Bruce Wirta, P. Hodgkins, A. Joseph, Economic burden associated with chronic constipation in Sweden: a retrospective cohort study, Clinicoecon. Outcomes Res. 6 (2014) 369-379. https://doi.org/10.2147/CEOR.S61985.
Crossref Google Scholar
[18]

P.B. Botelho, M.V.R. Ferreira, A.M. Araújo, et al., Effect of multi-species probiotic on gut microbiota composition on healthy individuals with intestinal constipation: a double-blind, placebo-controlled randomized trial, Nutrition 78 (2020) 110890. https://doi.org/10.1016/j.nut.2020.110890.
Crossref Google Scholar
[19]

Y. Lu, J. Zhang, Z. Zhang, et al., Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release, Nutrition. 84 (2021) 111112. https://doi.org/10.1016/j.nut.2020.111112.
Crossref Google Scholar
[20]

J.C. Wang, X.Y. Bai, C.T. Peng, et al., Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic pathways, J. Dairy Sci. 103 (2020) 11025-11038. https://doi.org/10.3168/jds.2020-18639.
Crossref Google Scholar
[21]

T. Didari, S. Solki, S. Mozaffari, et al., A systematic review of the safety of probiotics, Expert Opin. Drug Saf. 13 (2014) 227-239. https://doi.org/10.1517/14740338.2014.872627.
Crossref Google Scholar
[22]

M. Fernandez, J.A. Hudson, R. Korpela, et al., Impact on human health of microorganisms present in fermented dairy products: an overview, Biomed. Res. Int. 2015 (2015) 412714. https://doi.org/10.1155/2015/412714.
Crossref Google Scholar
[23]

J.P. Higgins, S.G. Thompson, J.J. Decks, et al., Measuring inconsistency in meta-analyses, BMJ. 327 (2003) 557-560. https://doi.org/10.1136/bmj.327.7414.557.
Crossref Google Scholar
[24]

M. Egger, G. Davey Smith, M. Schneider, et al., Bias in meta-analysis detected by a simple, graphical test, BMJ. 315 (1997) 629-634. https://doi.org/10.1136/bmj.315.7109.629.
Crossref Google Scholar
[25]

M. Mirghafourvand, A.H. Rad, S.M.A. Charandabi, et al., The effect of probiotic yogurt on constipation in pregnant women: a randomized controlled clinical trial, Iran. Red Crescent Med. J. 18 (2016) e39870. https://doi.org/10.5812/ircmj.39870.
Crossref Google Scholar
[26]

M.Y.A. Ghafar, H. Yaakup, R.A.R. Ali, et al., Evaluation of the efficacy of probiotics (MCP® BCMC® Strains) treating constipation in elderly patients with multiple chronic co-morbidities: a randomized control trial, J. Nutr. Health Aging. 24 (2020) 1066-1072. https://doi.org/10.1007/s12603-020-1494-1.
Crossref Google Scholar
[27]

Y.X. Yang, M. He, G. Hu, et al., Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women, World J. Gastroenterol. 14 (2008) 6237-6243. https://doi.org/10.3748/wjg.14.6237.
Crossref Google Scholar
[28]

R.S. Madempudi, J. Neelamraju, J.J. Ahire, et al., Bacillus coagulans Unique IS2 in constipation: a Double-Blind, placebo-controlled study, Probiotics Antimicrob Proteins. 12 (2020) 335-342. https://doi.org/10.1007/s12602-019-09542-9.
Crossref Google Scholar
[29]

V. Ojetti, G. Ianiro, A. Tortora, et al., The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: a randomized, double-blind, placebo-controlled trial, J. Gastrointestin Liver Dis. 23 (2014) 387-391. https://doi.org/10.15403/jgld.2014.1121.234.elr.
Crossref Google Scholar
[30]

A.H. Tan, S.Y. Lim, K.K. Chong, et al., Probiotics for constipation in parkinson disease: a randomized placebo-controlled study, Neurology 96 (2021) e772-e782. https://doi.org/10.1212/WNL.0000000000010998.
Crossref Google Scholar
[31]

C.J. Martoni, S. Srivastava, G.J. Leyer, Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 improve abdominal pain severity and symptomology in irritable bowel syndrome: randomized controlled trial, Nutrients 12 (2020) 363. https://doi.org/10.3390/nu12020363.
Crossref Google Scholar
[32]

H.J. Kim, M.I. Vazquez Roque, M. Camilleri, et al., A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating, Neurogastroenterol Motil. 17 (2005) 687-696. https://doi.org/10.1111/j.1365-2982.2005.00695.x.
Crossref Google Scholar
[33]

A.K. Gupta, C. Maity, Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: a prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant], Medicine 100 (2021) e23641. https://doi.org/10.1097/MD.0000000000023641.
Crossref Google Scholar
[34]

D. Charbonneau, R.D. Gibb, E.M. Quigley, Fecal excretion of Bifidobacterium infantis 35624 and changes in fecal microbiota after eight weeks of oral supplementation with encapsulated probiotic, Gut Microbes. 4 (2013) 201-211. https://doi.org/10.4161/gmic.24196.
Crossref Google Scholar
[35]

M.J. Kommers, R.A. Silva Rodrigues, F. Miyajima, et al., Effects of probiotic use on quality of life and physical activity in constipated female university students: a randomized, double-blind placebo-controlled study, J. Altern. Complement Med. 25 (2019) 1163-1171. https://doi.org/10.1089/acm.2019.0134.
Crossref Google Scholar
[36]

E. Dimidi, A. Zdanaviciene, S. Christodoulides, et al., Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation, Aliment Pharmacol. Ther. 49 (2019) 251-264. https://doi.org/10.1111/apt.15073.
Crossref Google Scholar
[37]

V. Mezzasalma, E. Manfrini, E. Ferri, et al., A randomized, double-Blind, placebo-controlled trial: the efficacy of multispecies probiotic supplementation in alleviating symptoms of irritable bowel syndrome associated with constipation, Biomed. Res. Int. 2016 (2016) 4740907. https://doi.org/10.1155/2016/4740907.
Crossref Google Scholar
[38]

M. Govender, Y.E. Choonara, P. Kumar, et al., A review of the advancements in probiotic delivery: conventional vs. non-conventional formulations for intestinal flora supplementation, AAPS PharmSciTech. 15 (2014) 29. https://doi.org/10.1208/s12249-013-0027-1.
Crossref Google Scholar
[39]

B. Albertini, B. Vitali, N. Passeriniet, et al., Development of microparticulate systems for intestinal delivery of Lactobacillus acidophilus and Bifidobacterium lactis, Eur. J. Pharm. Sci. 40 (2010) 359-366. https://doi.org/10.1016/j.ejps.2010.04.011.
Crossref Google Scholar
[40]

S. Rokka, P. Rantamki, Protecting probiotic bacteria by microencapsulation: challenges for industrial applications, Eur. Food Res. Technol. 231 (2010) 1-12. https://doi.org/10.1007/s00217-010-1246-2.
Crossref Google Scholar
[41]

A.T. Holkem, G.C. Raddatz, G.L. Nunes, et al., Development and characterization of alginate microcapsules containing Bifidobacterium BB-12 produced by emulsification/internal gelation followed by freeze drying, Lebensm. Wiss Technol. 71 (2016) 302-308. https://doi.org/10.1016/j.lwt.2016.04.012.
Crossref Google Scholar
[42]

M. Zhuang, W. Shang, Q. Ma, et al., Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion, Mol. Nutr. Food Res. 63 (2019). https://doi.org/10.1002/mnfr.201801187.
Crossref Google Scholar
[43]

M.M. Mazlyn, L.H. Nagarajah, A. Fatimah, et al., Effects of a probiotic fermented milk on functional constipation: a randomized, double-blind, placebo-controlled study, J. Gastroenterol. Hepatol. 28 (2013) 1141-1147. https://doi.org/10.1111/jgh.12168.
Crossref Google Scholar
[44]

Y. Zhang, L. Li, C. Guo, et al., Effects of probiotic type, dose and treatment duration on irritable bowel syndrome diagnosed by Rome Ⅲ criteria: a meta-analysis, BMC Gastroenterol. 16 (2016) 62. https://doi.org/10.1186/s12876-016-0470-z.
Crossref Google Scholar
[45]

H.M. Timmerman, C. Koning, L. Mulder, et al., Monostrain, multistrain and multispecies probiotics-A comparison of functionality and efficacy, Int. J. Food Microbiol. 96 (2004) 219-233. https://doi.org/10.1016/j.ijfoodmicro.2004.05.012.
Crossref Google Scholar
[46]

M. Camilleri, A.C. Ford, G.M. Mawe, et al., Chronic constipation, Nat. Rev. Dis. Primers. 3 (2017) 17095. https://doi.org/10.1038/nrdp.2017.95.
Crossref Google Scholar
[47]

E.J. Videlock, V. Cheng, F. Cremonini, Effects of linaclotide in patients with irritable bowel syndrome with constipation or chronic constipation: a meta-analysis, Clin. Gastroenterol. Hepatol. 11 (2013) 1084-1092. https://doi.org/10.1016/j.cgh.2013.04.032.
Crossref Google Scholar
[48]

J.F. Johanson, J. Kralstein, Chronic constipation: a survey of the patient perspective, Aliment Pharmacol. Ther. 25 (2007) 599-608. https://doi.org/10.1111/j.1365-2036.2006.03238.x.
Crossref Google Scholar
[49]

E. Dimidi, S. Christodoulides, K.C. Fragkos, et al., The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials, Am. J. Clin. Nutr. 100 (2014) 1075-1084. https://doi.org/10.3945/ajcn.114.089151.
Crossref Google Scholar
[50]

X. Ge, W. Zhao, C. Ding, et al., Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility, Sci. Rep. 7 (2017) 441. https://doi.org/10.1038/s41598-017-00612-y.
Crossref Google Scholar
[51]

Y. Tian, L. Zuo, Q. Guo, et al., Potential role of fecal microbiota in patients with constipation, Therap. Adv. Gastroenterol. 13 (2020) 175628482096842. https://doi.org/10.1177/1756284820968423.
Crossref Google Scholar
[52]

G. Yao, C. Cao, M. Zhang, et al., Lactobacillus casei Zhang exerts probiotic effects to antibiotic-treated rats, Comput. Struct. Biotechnol. J. 19 (2021) 5888-5897. https://doi.org/10.1016/j.csbj.2021.10.026.
Crossref Google Scholar
[53]

C.J. Martoni, M. Evans, C.T. Chow, et al., Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: a randomized controlled trial, J. Dig. Dis. 20 (2019) 435-446. https://doi.org/10.1111/1751-2980.12797.
Crossref Google Scholar
Food Science and Human Wellness
Volume 12 Issue 6,
November 2023
Pages 2124-2134
DOI: 10.1016/j.fshw.2023.03.024
Cite this article:
Yan J, Wu M, Zhao W, et al. Effects of probiotics and its fermented milk on constipation: a systematic review. Food Science and Human Wellness, 2023, 12(6): 2124-2134. https://doi.org/10.1016/j.fshw.2023.03.024

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Received: 27 July 2021
Revised: 03 September 2021
Accepted: 01 November 2021
Published: 04 April 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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