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Research Article | Open Access

Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats

Ali Y. Naooma, Wenyi Kangb, Nora F. Ghanemc, Mohamed M. Abdel-Daimd,e, Fatma M. El-Demerdashf( )
Department of Medical Laboratory Techniques, Imam Ja'afar Al-Sadiq University, Al-Muthanna 66002, Iraq
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
Department of Zoology, Faculty of Science, Kafr ElSheikh University, Kafr El Sheikh 33516, Egypt
Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia
Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt
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Abstract

This study aimed to evaluate the anti-hyperglycemic and antioxidant role of Actinidia deliciosa (kiwifruits) aqueous extract in streptozotocin-treated rats. Animals were distributed into; control, A. deliciosa aqueous extract (ADAE; 1 g/kg orally), streptozotocin (STZ; 50 mg/kg, i.p, single dose), and STZ plus ADAE, respectively. Results showed that ADAE had high antioxidant and radical scavenging potency. Elevation in blood sugar level, lipid peroxidation (LPO), kidney function biomarkers, and perturbations in hematological parameters were observed in diabetic rats. While, enzymatic and non-enzymatic antioxidants, protein content, and alkaline phosphatase (ALP) activity declined. Furthermore, histological, immunohistochemical alpha-smooth muscle actin immunoreactivity (α-SMA-ir) and histochemical (collagen, total protein, DNA, and RNA) alterations were observed in rat kidneys. Moreover, STZ produced upregulation of inflammatory associated genes (tumor necrosis factor-alpha; TNF-α and transforming growth factor β1; TGF-β1) and triggered apoptosis by upregulating apoptotic related gene [Bcl2-associated X protein (Bax)] and downregulating anti-apoptotic related gene B-cell lymphoma-2 (Bcl-2) based on real-time PCR data. Moreover, diabetic rats administered with ADAE showed significant restoration in LPO, antioxidant status, and biochemical indices besides tissue architecture, and genes improvement regarding STZ group. Conclusively, A. deliciosa has a valuable ameliorative influence and can restore glucose levels and improve kidney dysfunction in diabetic rats.

Keywords

Diabetes mellitusActinidia deliciosaInflammationApoptosisOxidative stressNephropathy

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Food Science and Human Wellness
Volume 12 Issue 6,
November 2023
Pages 1981-1990
DOI: 10.1016/j.fshw.2023.03.019
Cite this article:
Naoom AY, Kang W, Ghanem NF, et al. Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats. Food Science and Human Wellness, 2023, 12(6): 1981-1990. https://doi.org/10.1016/j.fshw.2023.03.019

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Received: 25 November 2021
Revised: 04 January 2022
Accepted: 03 March 2022
Published: 04 April 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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