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Research Article | Open Access

The dual-function of bioactive peptides derived from oyster (Crassostrea gigas) proteins hydrolysates

Dongyang Zhua, Zhen Yuana, Di Wua, Chao Wua, Hesham R. El-Seedib,c, Ming Dua( )
School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China
Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Uppsala SE 751 24, Sweden
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Oysters (Crassostrea gigas) have a wide range of functionality due to their nutritional and bioactive components. However, the bioactive peptides of oyster proteins are rarely reported, particularly their anti-diabetes effects and antioxidants. Oyster proteins were extracted from fresh oysters using phosphate-buffered saline and simulated gastrointestinal digestion was performed. The degree of hydrolysis (DH), structural characterization, molecular weight (Mw) distribution, free amino acid, anti-diabetic activity, and antioxidant activity were studied during in vitro simulated gastrointestinal digestion. The results showed that the α-glucosidase inhibitory activity, α-amylase inhibitory activity, DPPH radical scavenging activity, and ABTS radical scavenging activity of the oyster protein gastrointestinal digest were increased (P < 0.05) from 0 to 33.96 %, from 9.17 % to 44.22 %, from 9.01 µg trolox/mg protein to 18.48 µg trolox/mg protein, and from 21.44 µg trolox/mg protein to 56.21 µg trolox/mg protein, respectively. Additionally, the DH, β-turn structure, fluorescence intensity, free amino acid, and short peptide content (Mw < 1000 Da) increased in the simulated gastrointestinal digestion. These results indicate that the digestive hydrolysates obtained from oyster proteins could be used as natural anti-diabetic and antioxidant agents.

Keywords

Oyster proteinsSimulated gastrointestinal digestionAnti-diabetic activityAntioxidant activityFree amino acid

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Food Science and Human Wellness
Volume 12 Issue 5,
September 2023
Pages 1609-1617
DOI: 10.1016/j.fshw.2023.02.006
Cite this article:
Zhu D, Yuan Z, Wu D, et al. The dual-function of bioactive peptides derived from oyster (Crassostrea gigas) proteins hydrolysates. Food Science and Human Wellness, 2023, 12(5): 1609-1617. https://doi.org/10.1016/j.fshw.2023.02.006

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Received: 27 April 2022
Revised: 13 June 2022
Accepted: 21 August 2022
Published: 21 March 2023
© 2023 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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