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Research Article | Open Access

Effect of fructooligosaccharides on the colonization of Lactobacillus rhamnosus AS 1.2466T in the gut of mice

Zhihua Niua,1, Meijuan Zoua,1, Tingting Beia,1, Na Zhanga,b, Dongyao Lia, Miaoshu Wangc,d, Chen Lia,d( ), Hongtao Tiana,d,e( )
College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China
College of Biochemistry and Environmental Engineering, Baoding University, Baoding 071000, China
New Hope Tensun (Hebei) Dairy Co., Ltd, Baoding 071000, China
Hebei Technology Innovation Center of Probiotic Functional Dairy Product, Baoding 071000, China
National Engineering Research Center for Agriculture in Northern Mountainous Areas, Baoding 071000, China

1 Authors contributed equally to this work.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

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Abstract

Lactobacillus rhamnosus and fructooligosaccharides (FOS) have been widely studied so far. However, the effects of L. rhamnosus on the intestinal microecological environment at the species level and the effect of different proportions of FOS on L. rhamnosus colonization in different parts of mice intestine are still unclear. The study results indicated that the specific bands of enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) in the L. rhamnosus (LR) group significantly increased at 7 days. Although the number of bands was similar to the natural recovery (NR) group, the brightness of few bands significantly enhanced in the later stage of recovery. Besides, Southern-blot maps showed strong signals, indicating that the ERIC-PCR fingerprint could accurately reflect the changes in the mouse gut microbiota diversity. Further, the high-throughput results confirmed that the Lactobacillus and Akkermansia had different changes at different periods, but all of them showed an upward trend, while the Klebsiella were inhibited, thereby maintaining the intestinal microecology balance. Moreover, FOS exerted a positive effect on L. rhamnosus colonization in the gut.

Keywords

Intestinal microbiotaSynbioticsFructooligosaccharidesLactobacillus rhamnosus

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Food Science and Human Wellness
Volume 12 Issue 2,
March 2023
Pages 607-613
DOI: 10.1016/j.fshw.2022.07.063
Cite this article:
Niu Z, Zou M, Bei T, et al. Effect of fructooligosaccharides on the colonization of Lactobacillus rhamnosus AS 1.2466T in the gut of mice. Food Science and Human Wellness, 2023, 12(2): 607-613. https://doi.org/10.1016/j.fshw.2022.07.063

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Received: 02 May 2021
Revised: 27 June 2021
Accepted: 13 October 2021
Published: 07 September 2022
© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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