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Research Article | Open Access

Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil

Lina Tao, Panpan Wang, Ting Zhang, Mengzhen Ding, Lijie Liu, Ningping Tao, Xichang Wang, Jian Zhong( )
National R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery. In this work, we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish oil. The spherical capsules had diameters from 2.05 mm to 0.35 mm with the increased applied voltages. The capsules consisted of uniform (at applied voltages of ≤ 10 kV) or nonuniform (at applied voltages of > 10 kV) multicores. The obtained capsules had reasonable loading ratios (9.7%−6.3%) due to the multicore structure. In addition, the obtained capsules had specific and sustained release behaviors of fish oil into the small intestinal phase of in vitro gastrointestinal tract and small intestinal tract models. The simple monoaxial dispersion electrospraying-ionotropic gelatin technique does not involve complicated preparation formulations and polymer modification, which makes the technique has a potential application prospect for the fish oil preparations and the encapsulation of functional active substances in the field of food and drug industries.

Keywords

Ionotropic gelationMillimeter-sized spherical capsuleMonoaxial dispersion electrosprayingMulticoreSpecific and sustained release

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Food Science and Human Wellness
Volume 12 Issue 2,
March 2023
Pages 397-406
DOI: 10.1016/j.fshw.2022.07.041
Cite this article:
Tao L, Wang P, Zhang T, et al. Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil. Food Science and Human Wellness, 2023, 12(2): 397-406. https://doi.org/10.1016/j.fshw.2022.07.041

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Received: 27 December 2020
Revised: 12 January 2021
Accepted: 30 April 2021
Published: 07 September 2022
© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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