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Food Science and Human Wellness 2022, 11(4): 1076-1085 https://doi.org/10.1016/j.fshw.2022.03.034
Research Article | Open Access | Issue | Published: 28 April 2022

Pomegranate peel polyphenols alleviate insulin resistance through the promotion of insulin signaling pathway in skeletal muscle of metabolic syndrome rats

Show Author's Information Xitong Zhanga,b,  Lin Dua,b,  Weimin Zhanga,b,  Mi Yanga,b,  Li Chena,b,  Chen Houa,b( ),  Jianke Lia,b( )
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an 710119, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Insulin resistance, Insulin signaling pathway, Metabolic syndrome, PPARγ, Pomegranate peel polyphenols
Cite this article:
Zhang X, Du L, Zhang W, et al. Pomegranate peel polyphenols alleviate insulin resistance through the promotion of insulin signaling pathway in skeletal muscle of metabolic syndrome rats. Food Science and Human Wellness, 2022, 11(4): 1076-1085. https://doi.org/10.1016/j.fshw.2022.03.034
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Abstract Full text About this article

Insulin resistance (IR) has been considered to be an important causative factor of metabolic syndrome (MetS). The present study investigated whether pomegranate peel polyphenols (PPPs) could prevent the development of MetS by improving IR in rats. Male Sprague-Dawley (SD) rats were fed high fat diet (HFD) to induce MetS and supplemented with different dosages of PPPs for 12 weeks. The results showed that HFD-induced insulin resistant rats had disordered metabolism of blood glucose, blood lipid, and terrible muscle fiber morphology when compared with normal diet-fed rats, but PPPs treatment at a dosage of 300 mg/kg·day significantly reversed these negative effects. Moreover, in skeletal muscle tissue of insulin resistant rats, PPPs treatments significantly increased the protein expressions of insulin receptor (InsR) and phosphorylated insulin receptor substrate 1 (IRS-1), stimulated peroxisome proliferator activated receptor gamma (PPARγ) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT/PKB) signaling pathway, and aggrandized the protein levels of phosphorylated glycogen synthase kinase-3β (GSK-3β) and glucose transporter 4 (GLUT4). Our results suggest that PPPs possess of the beneficial effects on alleviating IR by enhancing insulin sensitivity and regulating glucose metabolism.


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About this article

Pomegranate peel polyphenols alleviate insulin resistance through the promotion of insulin signaling pathway in skeletal muscle of metabolic syndrome rats

Show Author's information Xitong Zhanga,b, Lin Dua,b, Weimin Zhanga,b, Mi Yanga,b, Li Chena,b, Chen Houa,b( ), Jianke Lia,b( )
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an 710119, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Insulin resistance (IR) has been considered to be an important causative factor of metabolic syndrome (MetS). The present study investigated whether pomegranate peel polyphenols (PPPs) could prevent the development of MetS by improving IR in rats. Male Sprague-Dawley (SD) rats were fed high fat diet (HFD) to induce MetS and supplemented with different dosages of PPPs for 12 weeks. The results showed that HFD-induced insulin resistant rats had disordered metabolism of blood glucose, blood lipid, and terrible muscle fiber morphology when compared with normal diet-fed rats, but PPPs treatment at a dosage of 300 mg/kg·day significantly reversed these negative effects. Moreover, in skeletal muscle tissue of insulin resistant rats, PPPs treatments significantly increased the protein expressions of insulin receptor (InsR) and phosphorylated insulin receptor substrate 1 (IRS-1), stimulated peroxisome proliferator activated receptor gamma (PPARγ) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT/PKB) signaling pathway, and aggrandized the protein levels of phosphorylated glycogen synthase kinase-3β (GSK-3β) and glucose transporter 4 (GLUT4). Our results suggest that PPPs possess of the beneficial effects on alleviating IR by enhancing insulin sensitivity and regulating glucose metabolism.

Keywords: Insulin resistance, Insulin signaling pathway, Metabolic syndrome, PPARγ, Pomegranate peel polyphenols

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Publication history

Received: 28 February 2021
Revised: 02 April 2021
Accepted: 17 May 2021
Published: 28 April 2022
Issue date: July 2022

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© 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

This work was supported by the National Natural Science Foundation of China (31871801, 32001679), the Science and Technology Research of Shaanxi Province (2020QFY08-03), Forestry Science and Technology Programs of Shaanxi Province (SXLK2020-0213), and Fundamental Research Funds for the Central Universities (GK201604013).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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