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Food Science and Human Wellness 2022, 11(4): 1053-1063 https://doi.org/10.1016/j.fshw.2022.03.032
Research Article | Open Access | Issue | Published: 28 April 2022

Roles of Adinandra nitida (Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice

Show Author's Information Erdong Yuana,1,  Yingyi Liana,1,  Qiuhua Lib,  Zhaoxiang Laib,  Lingli Sunb,  Xingfei Laib,  Ruohong Chenb,  Shuai Wenb,  Junquan Zhuc,  Wenji Zhangb( ),  Shili Sunb( )
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China
Tea Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
Guangdong Society of Plant Protection, Guangdong 510640, China

1 These authors contributed equally to this work.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Keywords:
Anti-inflammation, Oxidative stress, Adinandra nitida (Theaceae), Camellianin A, Gastric ulcer
Cite this article:
Yuan E, Lian Y, Li Q, et al. Roles of Adinandra nitida (Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice. Food Science and Human Wellness, 2022, 11(4): 1053-1063. https://doi.org/10.1016/j.fshw.2022.03.032
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Abstract Full text About this article

Gastric ulcer is a global health concern nowadays. Adinandra nitida, known as Shibi tea, is a flavonoid-rich plant found in South China. A. nitida possesses many healthy properties, such as antioxidation and reducing blood pressure. However, its effects on gastric ulcer have not been investigated. This study aimed to investigate the effects of the Shibi tea water extract (STE) and its main flavonoid camellianin A (CA) in hydrochloric acid (HCl) and ethanol (EtOH)-induced acute gastric ulcer in mice. Administration of CA and STE for continuous two days after stimulation by HCl/EtOH significantly attenuated the deterioration of gastric mucosal damage by lowering the gross gastric mucosal index, histopathological injury index, the oxidative stress, the expression of the inflammatory cytokines TNF-α and IL-6, and the expression of inflammatory mediators iNOS and COX-2. Western blotting and immunohistochemistry analysis showed that CA and STE regulated the inflammatory signaling pathway protein levels of IκB-α and NF-κB. Taken together, our study verified that CA and STE have antioxidative and anti-inflammatory effects in gastric ulcer mice. We propose that A. nitida should be developed as natural functional food for acute gastric ulcer patients base on the gastroprotective effects of STE and its main flavonoid CA.


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About this article

Roles of Adinandra nitida (Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice

Show Author's information Erdong Yuana,1, Yingyi Liana,1, Qiuhua Lib, Zhaoxiang Laib, Lingli Sunb, Xingfei Laib, Ruohong Chenb, Shuai Wenb, Junquan Zhuc, Wenji Zhangb( ), Shili Sunb( )
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China
Tea Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China
Guangdong Society of Plant Protection, Guangdong 510640, China

1 These authors contributed equally to this work.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Abstract

Gastric ulcer is a global health concern nowadays. Adinandra nitida, known as Shibi tea, is a flavonoid-rich plant found in South China. A. nitida possesses many healthy properties, such as antioxidation and reducing blood pressure. However, its effects on gastric ulcer have not been investigated. This study aimed to investigate the effects of the Shibi tea water extract (STE) and its main flavonoid camellianin A (CA) in hydrochloric acid (HCl) and ethanol (EtOH)-induced acute gastric ulcer in mice. Administration of CA and STE for continuous two days after stimulation by HCl/EtOH significantly attenuated the deterioration of gastric mucosal damage by lowering the gross gastric mucosal index, histopathological injury index, the oxidative stress, the expression of the inflammatory cytokines TNF-α and IL-6, and the expression of inflammatory mediators iNOS and COX-2. Western blotting and immunohistochemistry analysis showed that CA and STE regulated the inflammatory signaling pathway protein levels of IκB-α and NF-κB. Taken together, our study verified that CA and STE have antioxidative and anti-inflammatory effects in gastric ulcer mice. We propose that A. nitida should be developed as natural functional food for acute gastric ulcer patients base on the gastroprotective effects of STE and its main flavonoid CA.

Keywords: Anti-inflammation, Oxidative stress, Adinandra nitida (Theaceae), Camellianin A, Gastric ulcer

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Publication history

Received: 30 December 2020
Revised: 29 March 2021
Accepted: 30 May 2021
Published: 28 April 2022
Issue date: July 2022

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© 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgement

This study was funded by the "14th Five-Year Plan" team-building projects of Guangdong Academy Agricultural Sciences (202126TD), National Natural Science Foundation of China (81903319, 81803236, 31800295), Guangdong Science and Technology program (2018KJYZ002), Guangdong Basic and Applied Basic Research Foundation (2020A1515011266), Qingyuan Science and Technology Program (DZXQY021, 181022114566189, 181022114566189, 2019A039, 2020KJJH042), Shaoguan Science and Technology Program (2018CS11902, 2018sn081), Guangzhou Science and Technology Program (202002030202), Zhaoqing Science and Technology Program (2019N001, 2019N013), Maoming Science and Technology Program (mmkj2020045), Zhanjiang Science and Technology Program (2020A03014), Yingde Science and Technology Board (JHXM2018029), Innovation Fund projects of Guangdong Academy of Agricultural Sciences (202115), Special fund for scientific innovation strategy-construction of high level Academy of Agriculture Science (R2019PY-JX004, R2018YJ-YB3002, R2016YJ-YB3003, R2018PY-QF005, R2018QD-101).

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