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Food Science and Human Wellness 2022, 11(4): 865-873 https://doi.org/10.1016/j.fshw.2022.03.009
Research Article | Open Access | Issue | Published: 28 April 2022

Effects of Siraitia grosvenorii extracts on high fat diet-induced obese mice: a comparison with artificial sweetener aspartame

Show Author's Information Ke Lüa,1,  Xiaowan Songa,1,  Peng Zhanga,1,  Wei Zhaoa,  Ning Zhanga,  Fan Yanga,  Wenqiang Guana,  Jianfu Liua,  He Huangb,  Chi-Tang Hoc,  Rong Did( ),  Hui Zhaoa( )
Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China
Department of Biochemical Engineering, School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin 300072, China
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
Department of Plant Biology, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA

1 The authors are equal contributors to this article.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Keywords:
Gut microbiota, Inflammation, High fat diet, Siraitia grosvenorii, Obese
Cite this article:
Lü K, Song X, Zhang P, et al. Effects of Siraitia grosvenorii extracts on high fat diet-induced obese mice: a comparison with artificial sweetener aspartame. Food Science and Human Wellness, 2022, 11(4): 865-873. https://doi.org/10.1016/j.fshw.2022.03.009
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Abstract Full text About this article

Long-term artificial sweetener intake is linked to increased risk of obesity. In the present study, supplement of natural sweetener from Siraitia grosvenorii (SG) (or Momordica grosvenorii) fruit, compared with the artificial sweetener aspartame (ASM), was evaluated for anti-obesity effects on mice fed with high fat diet (HFD). We found that, in contrary to ASM, SG extracts prevented body weight gain, the insulin resistance and fat mass accumulation in HFD mice. SG extracts treatment inhibited the infiltration of inflammatory macrophages and lowered the levels of the fat inflammatory cytokines (leptin, macrophage chemoattractant protein 1 (MCP-1) and tumor necrosis factor-α (TNF-α)) in adipose tissues. In addition, SG extracts supplement counteracted the remodeling of gut microbiota resulted from HFD. However, ASM supplement aggravated the HFD-induced obese performances, fat inflammation and dysregulation of gut microbiota. Taken together, our results indicate that supplement of SG extracts may represent a promising alternation of artificial sweeteners in preventing metabolic diseases.


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About this article

Effects of Siraitia grosvenorii extracts on high fat diet-induced obese mice: a comparison with artificial sweetener aspartame

Show Author's information Ke Lüa,1, Xiaowan Songa,1, Peng Zhanga,1, Wei Zhaoa, Ning Zhanga, Fan Yanga, Wenqiang Guana, Jianfu Liua, He Huangb, Chi-Tang Hoc, Rong Did( ), Hui Zhaoa( )
Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China
Department of Biochemical Engineering, School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin 300072, China
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
Department of Plant Biology, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA

1 The authors are equal contributors to this article.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Abstract

Long-term artificial sweetener intake is linked to increased risk of obesity. In the present study, supplement of natural sweetener from Siraitia grosvenorii (SG) (or Momordica grosvenorii) fruit, compared with the artificial sweetener aspartame (ASM), was evaluated for anti-obesity effects on mice fed with high fat diet (HFD). We found that, in contrary to ASM, SG extracts prevented body weight gain, the insulin resistance and fat mass accumulation in HFD mice. SG extracts treatment inhibited the infiltration of inflammatory macrophages and lowered the levels of the fat inflammatory cytokines (leptin, macrophage chemoattractant protein 1 (MCP-1) and tumor necrosis factor-α (TNF-α)) in adipose tissues. In addition, SG extracts supplement counteracted the remodeling of gut microbiota resulted from HFD. However, ASM supplement aggravated the HFD-induced obese performances, fat inflammation and dysregulation of gut microbiota. Taken together, our results indicate that supplement of SG extracts may represent a promising alternation of artificial sweeteners in preventing metabolic diseases.

Keywords: Gut microbiota, Inflammation, High fat diet, Siraitia grosvenorii, Obese

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Publication history

Received: 12 February 2020
Revised: 28 February 2021
Accepted: 07 March 2021
Published: 28 April 2022
Issue date: July 2022

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© 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgement

This work was supported by grants from the National Key Research and Development Program of China (No. 2019YFA0905600), Tianjin Innovative Team Project (TD13-5087), and Shangrao Crucial Research and Development Project (19A005).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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