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Food Science and Human Wellness 2022, 11(3): 738-751 https://doi.org/10.1016/j.fshw.2021.12.031
Research Article | Open Access | Issue | Published: 04 February 2022

Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet

Show Author's Information Meirong Wua,1,  Xiaobin Wua,1,  Jiangxiong Zhua,  Fanglan Lia,  Xinlin Weib( ),  Yuanfeng Wanga( )
Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China
Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China

1 These authors contributed equally to this study

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Hypertension, Green tea, High-salt diet, Selenium-enriched green tea, PI3K/Akt pathway, Microbial profile
Cite this article:
Wu M, Wu X, Zhu J, et al. Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet. Food Science and Human Wellness, 2022, 11(3): 738-751. https://doi.org/10.1016/j.fshw.2021.12.031
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Abstract Full text About this article

High-salt diet is well recognized as a risk factor for hypertension, and dietary intervention plays a critical role in the prevention of hypertension. The current study investigated the effects of selenium-enriched green tea (Se-GT) and ordinary green tea (GT) on prevention of hypertension of rats induced by high-salt diet, as well as their potential regulatory and mechanism. Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure (BP), activated the phosphoinosmde-3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and regulated the gene expression related to BP, as well as improved the tissue damage like heart, liver, and kidneys. Besides, the key parameters associated with oxidative stress, inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments. Importantly, GT or Se-GT administration adjusted the diversity and composition of the intestinal flora. Moreover, GT and Se-GT supplementations increased the abundance of beneficial bacteria and reduced the abundance of harmful or conditional pathogenic bacteria. More specifically, GT intake specifically and significantly enriched the relative abundance of Paraprevotella and Bacteroides, whereas Se-GT was characterized by specific and significant enrichment for Allobaculum and Bifidobacterium. Our results proved that dietary supplement of GT and Se-GT remarkably improved the vascular functions and effectively prevented tissue damage by regulation of intestinal flora, and thus preventing hypertension induced by high-salt diet.


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About this article

Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet

Show Author's information Meirong Wua,1, Xiaobin Wua,1, Jiangxiong Zhua, Fanglan Lia, Xinlin Weib( ), Yuanfeng Wanga( )
Development Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China
Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China

1 These authors contributed equally to this study

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

High-salt diet is well recognized as a risk factor for hypertension, and dietary intervention plays a critical role in the prevention of hypertension. The current study investigated the effects of selenium-enriched green tea (Se-GT) and ordinary green tea (GT) on prevention of hypertension of rats induced by high-salt diet, as well as their potential regulatory and mechanism. Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure (BP), activated the phosphoinosmde-3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and regulated the gene expression related to BP, as well as improved the tissue damage like heart, liver, and kidneys. Besides, the key parameters associated with oxidative stress, inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments. Importantly, GT or Se-GT administration adjusted the diversity and composition of the intestinal flora. Moreover, GT and Se-GT supplementations increased the abundance of beneficial bacteria and reduced the abundance of harmful or conditional pathogenic bacteria. More specifically, GT intake specifically and significantly enriched the relative abundance of Paraprevotella and Bacteroides, whereas Se-GT was characterized by specific and significant enrichment for Allobaculum and Bifidobacterium. Our results proved that dietary supplement of GT and Se-GT remarkably improved the vascular functions and effectively prevented tissue damage by regulation of intestinal flora, and thus preventing hypertension induced by high-salt diet.

Keywords: Hypertension, Green tea, High-salt diet, Selenium-enriched green tea, PI3K/Akt pathway, Microbial profile

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Publication history

Received: 01 September 2021
Revised: 29 September 2021
Accepted: 07 October 2021
Published: 04 February 2022
Issue date: May 2022

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© 2022 Beijing Academy of Food Sciences.

Acknowledgements

Acknowledgement

The authors are grateful for financial sponsored by the National Key R & D Program of China (No.2018YFC1604405), Fund of Shanghai Engineering Research Center of Plant Germplasm Resources (No. 17DZ2252700), and Research on the health function of tea and deep-processed products in preventing metabolic diseases (No. C-6105-20-074).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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