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Research Article | Open Access

Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages

Qi Wanga,c, Juqing Huanga,c, Yafeng Zhengb, Xuefang Guana,c, Chenchun Laia,c, Huiying Gaoa,c, Chi-Tang Hod, Bin Lina,c( )
Institute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, China
Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Both tea polyphenols and selenium (Se) have been suggested to exert the health benefits via the regulatory capacities of chronic inflammation, which make Se-enriched oolong tea a promising beverage as an anti-inflammatory diet. The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract (Se-TE) and underlying mechanism in lipopolysaccharide (LPS)-induced RAW264.7 cells. Se-TE treatments (50 and 150 μg/mL) significantly suppressed the over-production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, Se-TEs also effectively inhibited the productions of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). Furthermore, Se-TE could block mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways through the inhibition of the phosphorylation of key proteins (IκB-α, p65, p38, ERK, and JNK) and the translocation of the p65 subunit into the nucleus. Collectively, our results indicated that Se-TE may have the potential to be used as a novel food ingredient for the development of various anti-inflammatory foods and the treatment and prevention of chronic inflammation-related diseases.

Keywords

Oolong teaSeleniumAnti-inflammatoryNF-κB and MAPK pathways

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Food Science and Human Wellness
Volume 11 Issue 3,
May 2022
Pages 635-642
DOI: 10.1016/j.fshw.2021.12.020
Cite this article:
Wang Q, Huang J, Zheng Y, et al. Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages. Food Science and Human Wellness, 2022, 11(3): 635-642. https://doi.org/10.1016/j.fshw.2021.12.020

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Received: 20 January 2021
Revised: 28 February 2021
Accepted: 18 March 2021
Published: 04 February 2022
© 2022 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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