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Review Article | Open Access

Metabolic fate of tea polyphenols and their crosstalk with gut microbiota

Meiyan Wanga( ), Jianying Lia, Ting Hub( ), Hui Zhaoa( )
Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China
Hubei Key Laboratory for EFGIR, Huanggang Normal University, Huanggang 438000, China

Peer review under responsibility of KeAi Communications Co., Ltd.

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Abstract

Tea represents an abundant source of naturally occurring polyphenols. Tea polyphenols (TPs) have received growing attentions for its wide consumption in the world, and more importantly its pleiotropic bioeffects for human health. After ingestion, TPs may undergo absorption and phase II reaction in the small intestine, and most undigested proportion would be submitted to the colon to interact with gut microbiota. Interactions between gut microbiota and TPs are bidirectional, including not only bacteria-mediated TPs metabolism, e.g., removal of gallic acid moiety and ring fission to release phenolic acid catabolites, but also TPs-based modification of bacterial profiles. Crosstalk between TPs and gut microbes may benefit for gut barrier function, for example, improvement of the intestinal permeability to alleviate inflammation. Moreover, by reshaping microbial composition and associated metabolites, TPs may exert a systemic protection on host metabolism, which contributes to improve certain chronic metabolic disorders. Given that, further understanding of the metabolic fate of TPs and interplay with gut microbiota as well as potential health-promoting effects are of great significance to development and application of tea and their polyphenolic components in the future as dietary supplements and/or functional ingredients in medical foods.

Keywords

Tea polyphenolsMetabolismGut microbiotaBioeffects

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Food Science and Human Wellness
Volume 11 Issue 3,
May 2022
Pages 455-466
DOI: 10.1016/j.fshw.2021.12.003
Cite this article:
Wang M, Li J, Hu T, et al. Metabolic fate of tea polyphenols and their crosstalk with gut microbiota. Food Science and Human Wellness, 2022, 11(3): 455-466. https://doi.org/10.1016/j.fshw.2021.12.003

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Received: 29 December 2020
Revised: 09 January 2021
Accepted: 10 January 2021
Published: 04 February 2022
© 2022 Beijing Academy of Food Sciences.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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