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Food Science and Human Wellness 2020, 9(3): 214-228 https://doi.org/10.1016/j.fshw.2020.04.005
Review Article | Open Access | Issue | Published: 22 April 2020

Natural products: Regulating glucose metabolism and improving insulin resistance

Show Author's Information Fatma S.A. Saadeldeena,b,1,  Yun Niua,b,1,  Honglin Wanga,b,1,  Li Zhoua,b,  Lijun Menga,b,  Sitan Chena,b,  Dongxiao Sun-Waterhoused,  Geoffrey Ivan Neil Waterhoused,  Zhenhua Liua,b,c( ),  Wenyi Kanga,b,c( )
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Henan University, Kaifeng 475004, China
Kaifeng Key Laboratory of Functional Components in Health Food, Kaifeng 475004, Henan, China
School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand

1 These authors contributed equally to this work.Peer review under responsibility of KeAi Communications Co., Ltd]]>

Keywords:
Glucose metabolism, Natural products, Insulin resistance (IR)
Cite this article:
Saadeldeen FS, Niu Y, Wang H, et al. Natural products: Regulating glucose metabolism and improving insulin resistance. Food Science and Human Wellness, 2020, 9(3): 214-228. https://doi.org/10.1016/j.fshw.2020.04.005
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Abstract Full text About this article

Compounds with regulating glucose metabolism and improving insulin resistance (IR) activity are abundant in nature and can be obtained from several sources. They have high potential to be used to treat diabetes mellitus. These compounds isolated from natural plants can be classified seven categories: terpenoids, alkaloids, quinones, flavonoids, phenols, phenyl propanoids, steroids, and other types of compounds. They exert biological effects by different ways and mechanisms. This review illustrated the potential natural products as a rich resource in regulation of glucose metabolism and IR, as well as their mechanisms.


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About this article

Natural products: Regulating glucose metabolism and improving insulin resistance

Show Author's information Fatma S.A. Saadeldeena,b,1, Yun Niua,b,1, Honglin Wanga,b,1, Li Zhoua,b, Lijun Menga,b, Sitan Chena,b, Dongxiao Sun-Waterhoused, Geoffrey Ivan Neil Waterhoused, Zhenhua Liua,b,c( ), Wenyi Kanga,b,c( )
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Henan University, Kaifeng 475004, China
Kaifeng Key Laboratory of Functional Components in Health Food, Kaifeng 475004, Henan, China
School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand

1 These authors contributed equally to this work.Peer review under responsibility of KeAi Communications Co., Ltd]]>

Abstract

Compounds with regulating glucose metabolism and improving insulin resistance (IR) activity are abundant in nature and can be obtained from several sources. They have high potential to be used to treat diabetes mellitus. These compounds isolated from natural plants can be classified seven categories: terpenoids, alkaloids, quinones, flavonoids, phenols, phenyl propanoids, steroids, and other types of compounds. They exert biological effects by different ways and mechanisms. This review illustrated the potential natural products as a rich resource in regulation of glucose metabolism and IR, as well as their mechanisms.

Keywords: Glucose metabolism, Natural products, Insulin resistance (IR)

References(103)

[1]

C. Lankatillake, T. Huynh, D.A. Dias, Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants, Plant Methods 15 (105) (2019), http://doi.org/10.1186/s13007-019-0487-8.
DOI Google Scholar
[2]

H. Hussain, I.R. Green, G. Abbas, et al., Protein tyrosine phosphatase 1B (PTP1B) inhibitors as potential anti-diabetes agents: patent review (2015-2018), Expert Opin. Ther. Pat. (2019), http://doi.org/10.1080/13543776.2019.1655542.
DOI Google Scholar
[3]

S. Guo, Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms, Endocrinology 220 (2) (2014) 1-23, http://doi.org/10.1530/JOE-13-0327.
DOI Google Scholar
[4]

M.J. Robinson, H. Cobb, Mitogen activated protein kinase pathway, Curr. Opin. Cell Biol. 9 (2) (1997) 180-186.
DOI Google Scholar
[5]

L.S. Harrington, G.M. Findlay, A. Gray, et al., The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins, Cell Biol. 166 (2) (2004) 213-223.
DOI Google Scholar
[6]

E.W. Kraegen, P.W. Clark, A.B. Jenkins, et al., Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats, Diabetes 40 (11) (1991) 1397-1403, http://doi.org/10.2337/diab.40.11.1397.
DOI Google Scholar
[7]

A. Guilherme, J.V. Virbasius, V. Puri, et al., Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes, Nat. Rev. Mol. Cell Biol. 9 (5) (2008) 367-377, http://doi.org/10.1038/nrm2391.
DOI Google Scholar
[8]

J. Choi, K.J. Kim, E.J. Koh, et al., Gelidium elegans extract ameliorates type 2 diabetes via regulation of MAPK and PI3K/Akt signaling, Nutrients 10 (1) (2018) 51-64, http://doi.org/10.3390/nu10010051.
DOI Google Scholar
[9]

H. Ando, T. Takamura, N. Matsuzawanagata, et al., The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis, Biochem. Biophys. Res. Commun. 380 (3) (2009) 684-688, http://doi.org/10.1016/j.bbrc.2009.01.150.
DOI Google Scholar
[10]

E.L. Seifert, C. Estey, J.Y. Xuan, et al., Electron transport chain-dependent and -independent mechanisms of mitochondrial h2o2 emission during long-chain fatty acid oxidation, Biol. Chem. 285 (8) (2010) 5748.
DOI Google Scholar
[11]

P. Lebrun, E. Cognard, R. Bellon-Paul, et al., Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice, Diabetologia 52 (10) (2009) 2201-2212, http://doi.org/10.1007/s00125-009-1474-9.
DOI Google Scholar
[12]

B.B. Yaspelkis, I.A. Kvasha, T.Y. Figueroa, High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKalpha/beta phosphorylation and decreases PI-3 kinase activity in muscle, Am. J. Physiol. -Regul. Intergr. Compar. Physiol. 296 (6) (2009) 1709-1715, http://doi.org/10.1152/ajpregu.00117.2009.
DOI Google Scholar
[13]

N. Kallscheuer, T. Classen, T. Drepper, et al., Production of plant metabolites with applications in the food industry using engineered microorganisms, Curr. Opin. Biotechnol. 56 (2019) 7-17, http://doi.org/10.1016/j.copbio.2018.07.008.
DOI Google Scholar
[14]

Y. Zhang, L.J. Yu, W.J. Cai, Protopanaxatriol, a novel PPAR gamma antagonist from Panax ginseng, alleviates steatosis in mice, Sci. Rep. 4 (2014) 7375, http://doi.org/10.1038/srep07375.
DOI Google Scholar
[15]

Y. Huang, W. Chang, S. Huang, et al., Pachymic acid stimulates glucose uptake through enhanced GLUT4 expression and translocation, Eur. J. Pharmacol. 684 (2010) 39-49, http://doi.org/10.1016/j.ejphar.2010.08.021.
DOI Google Scholar
[16]

G.S. Banu, Cucurbitacin augments insulin sensitivity and glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway, World J. Pharm. Res. 6 (8) (2017) 1096-2017, http://doi.org/10.20959/wjpr20178-8924.
DOI Google Scholar
[17]

J.H. Qin, J.Z. Ma, X.W. Yang, et al., A triterpenoid inhibited hormone-induced adipocyte differentiation and alleviated dexamethasone-induced insulin resistance in 3t3-l1 adipocytes, Nat. Prod. Bioprospect. 5 (3) (2015) 159-166, http://doi.org/10.1007/s13659-015-0063-5.
DOI Google Scholar
[18]

R. Khanra, N. Bhattacharjee, T.K. Dua, et al., Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats, Biomed. Pharmacother. 94 (2017) 726-741, http://doi.org/10.1016/j.biopha.2017.07.112.
DOI Google Scholar
[19]

V. Ramachandran, R. Saravanan, Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats, Hum. Exp. Toxicol. 34 (9) (2015) 884-893, http://doi.org/10.1177/0960327114561663.
DOI Google Scholar
[20]

S.C. Wei, J.R. Wang, K.H. Ye, et al., Effect of guavenoic acid on improving insulin resistance in INS-1 cells and its mechanisms, Chin. Tradit. Patent Med. 37 (4) (2015) 710-715.
Google Scholar
[21]

Y. He, W. Li, Y. Li, et al., Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes, PLoS One 9 (10) (2014), http://doi.org/10.1371/journal.pone.0110711.
DOI Google Scholar
[22]

Y. Li, J. Wang, T. Gu, et al., Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats, Toxicol. Appl. Pharmacol. 277 (2) (2014) 155-163, http://doi.org/10.1016/j.taap.2014.03.016.
DOI Google Scholar
[23]

K.N. Zhu, C.H. Jiang, Y.S. Tian, Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: the relationship to AMPK activation, Phytomeddicine 22 (9) (2015) 837-846, http://doi.org/10.1016/j.phymed.2015.05.058.
DOI Google Scholar
[24]

M.S. Kang, S.Z. Hirai, T.Y. Goto, Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation, Biochem. Biophys. Res. Commun. 369 (2) (2008) 333-338, http://doi.org/10.1016/j.bbrc.2008.02.002.
DOI Google Scholar
[25]

D. Arha, S. Pandeti, A. Mishra, et al., Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic affect in vivo, Eur. J. Pharmacol. 768 (2015) 207-216, http://doi.org/10.1016/j.ejphar.2015.10.055.
DOI Google Scholar
[26]

F.F. Liu, M.W. Yang, X.Q. Wang, Effect of catalpol, berberine, and their combination on insulin resistant 3T3-L1 adipocytes, Chin. Tradit. Herbal Drugs 38 (10) (2007) 1523-1526.
Google Scholar
[27]

K. Park, Aucubin, a naturally occurring iridoid glycoside inhibits TNF-α-induced inflammatory responses through suppression of NF-κB activation in 3T3-L1 adipocytes, Cytokine 62 (3) (2013) 407-412, http://doi.org/10.1016/j.cyto.2013.04.005.
DOI Google Scholar
[28]

Z. Ma, L. Chu, H. Liu, et al., Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats, Sci. Rep. 7 (2017) 44819, http://doi.org/10.1038/srep44819.
DOI Google Scholar
[29]

C. Prata, L. Zambonin, B. Rizzo, et al., Glycosides from Stevia rebaudiana Bertoni possess insulin-mimetic and antioxidant activities in rat cardiac fibroblasts, Oxid. Med. Cell. Longev. 2017 (2017) 1-13, http://doi.org/10.1155/2017/3724545.
DOI Google Scholar
[30]

L. Jia, Y. Zhao, Current evaluation of the millennium phytomedicine-Ginseng (Ⅰ): etymology, pharmacognosy, phytochemistry, market and regulations, Curr. Med. Chem. 16 (19) (2009) 2475-2484, http://doi.org/10.2174/092986709788682146.
DOI Google Scholar
[31]

M.R. Tabandeh, S.A. Hosseini, M. Hosseini, Ginsenoside Rb1 exerts antidiabetic action on C2C12 muscle cells by leptin receptor signaling pathway, J. Recept. Signal Transduct. Res. 37 (4) (2017) 370-378, http://doi.org/10.1080/10799893.2017.1286676.
DOI Google Scholar
[32]

L. Lv, S.Y. Wu, G.F. Wang, et al., Effect of astragaloside Ⅳ on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin, Phytotherapy 24 (2010) 219-224, http://doi.org/10.1002/ptr.2915.
DOI Google Scholar
[33]

Q. Du, S.H. Zhang, A.Y. Li, et al., Astragaloside Ⅳ inhibits adipose lipolysis and reduces hepatic glucose production via Akt dependent PDE3B expression in HFFD-fed mice, Front. Physiol. 9 (2018) 15, http://doi.org/10.3389/fphys.2018.00015.
DOI Google Scholar
[34]

J.Y. Ahn, M.Y. Um, H.J. Lee, Eleutheroside E, an active component of Eleutherococcus senticosus, ameliorates insulin resistance in type 2 diabetic db/db mice, Evid. Based Complement. Altern. Med. (2013) 934183, http://doi.org/10.1155/2013/934183.
DOI Google Scholar
[35]

J. Wang, X. Hu, W. Ai, et al., Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet, Biochem. Biophys. Res. Commun. 489 (4) (2017) 432-438, http://doi.org/10.1016/j.bbrc.2017.05.160.
DOI Google Scholar
[36]

I. Soundharrajan, D.H. Kim, S. Srisesharam, et al., Limonene promotes osteoblast differentiation and 2-deoxy-d-glucose uptake through p38MAPK and Akt signaling pathways in C2C12 skeletal muscle cells, Phytomedicine 1 (45) (2018) 41-48, http://doi.org/10.1016/j.phymed.2018.03.019.
DOI Google Scholar
[37]

A. Rathinam, L. Pari, Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats, Chemico-Biol. Interact. 256 (2016) 161-166, http://doi.org/10.1016/j.cbi.2016.07.009.
DOI Google Scholar
[38]

L.Z. Liu, L.L. Cheung, S.K. Ho, et al., Berberine modulates insulin signaling transduction in insulin-resistant cells, Mol. Cell. Endocrinol. 317 (1) (2010) 148-153, http://doi.org/10.1016/j.mce.2009.12.027.
DOI Google Scholar
[39]

M.L. Zuo, A.P. Wang, Y. Tian, et al., Oxymatrine ameliorates insulin resistance in rats with type 2 diabetes by regulating the expression of KSRP, PETN, and Akt in the liver, J. Cell. Biochem. 120 (2019) 16185-16194, http://doi.org/10.1002/jcb.28898.
DOI Google Scholar
[40]

Y. Yoshioka, E. Harada, E. Ge, et al., Adenosine isolated from Grifola gargal promotes glucose uptake via PI3K and AMPK signaling pathways in skeletal muscle cells, J. Funct. Foods 33 (2017) 268-277, http://doi.org/10.1016/j.jff.2017.03.050.
DOI Google Scholar
[41]

N. Nooron, A. Athipornchai, A. Suksamrarn, et al., Mahanine enhances the glucose-lowering mechanisms in skeletal muscle and adipocyte cells, Biochem. Biophys. Res. Commun. 494 (2017) 101-106, http://doi.org/10.1016/j.bbrc.2017.10.075.
DOI Google Scholar
[42]

S.H. Kim, J.T. Hwang, H.S. Park, et al., Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway, Biochem. Biophys. Res. Commun. 439 (1) (2013) 66-70, http://doi.org/10.1016/j.bbrc.2013.08.027.
DOI Google Scholar
[43]

G. Naresh, N. Jaiswal, P. Sukanya, et al., Glucose uptake stimulatory effect of 4-hydroxypipecolic acid by increased GLUT 4 translocation in skeletal muscle cells, Bioorg. Med. Chem. Lett. 22 (17) (2012) 5648-5651, http://doi.org/10.1016/j.bmcl.2012.06.101.
DOI Google Scholar
[44]

Q. Liu, X. Li, C. Li, et al., 1-deoxynojirimycin alleviates insulin resistance via activation of insulin signaling pI3k/Akt pathway in skeletal muscle of db/db mice, Molecules 20 (12) (2015) 21700-21714, http://doi.org/10.3390/molecules201219794.
DOI Google Scholar
[45]

L. Xu, M. Xing, X. Xu, et al., Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice, Future Med. Chem. 11 (5) (2019), http://doi.org/10.4155/fmc-2018-0515.
DOI Google Scholar
[46]

Y.J. Wang, S.L. Huang, F. Ying, Emodin, an 11 beta-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice, Acta Pharmacol. Sin. 33 (9) (2020) 1195-1203, http://doi.org/10.1038/aps.2012.87.
DOI Google Scholar
[47]

Z.W. Gong, C. Huang, X.Y. Sheng, The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism, Endocrinology 150 (1) (2009) 104-113, http://doi.org/10.1210/en.2008-0322.
DOI Google Scholar
[48]

S. Pandeti, D. Arha, A. Mishra, et al., Glucose uptake stimulatory potential and antidiabetic activity of the Arnebin-1 from Arnabia nobelis, Eur. J. Pharmacol. 789 (2016) 449-457, http://doi.org/10.1016/j.ejphar.2016.08.010.
DOI Google Scholar
[49]

S.S. Choi, B.Y. Cha, Y.S. Lee, Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells, Life Sci. 84 (25) (2009) 908-914, http://doi.org/10.1016/j.lfs.2009.04.001.
DOI Google Scholar
[50]

A.K. Tamrakar, N. Jaiswal, P.P. Yadav, et al., Pongamol from Pongamia pinnata, stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells, Mol. Cell. Endocrinol. 339 (2011) 98-104.
DOI Google Scholar
[51]

G.L. Shyni, S. Kavitha, K.F. Sajin, et al., Licarin B from Myristica fragrans improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/Akt pathway in 3T3-L1 adipocytes, RSC Adv. 6 (83) (2016) 79859-79870, http://doi.org/10.1039/C6RA13055K.
DOI Google Scholar
[52]

N. Hyun, J.J. Kim, Y.N. Kim, Chokeberry extract and its active polyphenols suppress adipogenesis in 3T3-L1 adipocytes and modulates fat accumulation and insulin resistance in diet-induced obese mice, Nutrients 10 (11) (2018) 1734, http://doi.org/10.3390/nu10111734.
DOI Google Scholar
[53]

J.T. Hwang, S.H. Kim, H.J. Hur, Decursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet, Phytother. Res. 26 (5) (2012) 633-638, http://doi.org/10.1002/ptr.3612.
DOI Google Scholar
[54]

K.W. Ong, A. Hsu, B.K.H. Tan, Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes, PLoS One 7 (3) (2013), http://doi.org/10.1371/journal.pone.0032718.
DOI Google Scholar
[55]

S.H. Kim, H.S. Park, M.J. Hong, Caffeic acid phenethyl ester improves metabolic syndrome by activating PPAR-gamma and inducing adipose tissue remodeling in diet-induced obese mice, Mol. Nutr. Food Res. 62 (10) (2018), http://doi.org/10.1002/mnfr.201700701.
DOI Google Scholar
[56]

X.Q. Xu, F.S.A. Saadeldeen, L.T. Xu, et al., The mechanism of phillyrin from the leaves of Forsythia suspensa for improving insulin resistance, Biomed Res. Int. (2019), http://doi.org/10.1155/2019/3176483.
DOI Google Scholar
[57]

H.J. Lee, H. Li, J.J. Hye, Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes, Fitoterapia 112 (2016) 90-96, http://doi.org/10.1016/j.fitote.2016.05.006.
DOI Google Scholar
[58]

P.J. Wang, S.Y. Xu, W.Z. Li, Salvianolic acid B inhibited PPAR gamma expression and attenuated weight gain in mice with high-fat diet-induced obesity, Cell. Physiol. Biochem. 2 (2014) 288-298, http://doi.org/10.1159/000362999.
DOI Google Scholar
[59]

Y.F. Ma, Y.J. Wu, J.K. Y, et al., Flavonoids content and antioxidant activity of ethanol extracts of Osmanthus fragrans flowers, Bangladesh J. Bot. 46 (3) (2017) 907-915.
Google Scholar
[60]

E.J. Bak, J. Kim, Y.H. Choi, Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice, Clin. Nutr. 33 (1) (2014) 156-163, http://doi.org/10.1016/j.clnu.2013.03.013.
DOI Google Scholar
[61]

E.Y. Kwon, M.S. Choi, Luteolin, targets the toll-like receptor signaling pathway in prevention of hepatic and adipocyte fibrosis and insulin resistance in diet-induced obese mice, Nutrients 10 (10) (2018), http://doi.org/10.3390/nu10101415.
DOI Google Scholar
[62]

G. Ling, C. Yajun, W. Zhangda, et al., Effect of quercetin on insulin resistance and FGF21/MAPK signaling pathway in type 2 diabetic rats, China Pharmacist (2019).
Google Scholar
[63]

J. Dong, X.A. Zhang, L. Zhang, Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPK alpha 1/SIRT1, J. Lipid Res. 55 (3) (2014) 363-374, http://doi.org/10.1194/jlr.M038786.
DOI Google Scholar
[64]

J.Z. Shen, L.N. Ma, Y. Han, Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase, Diabetologia 55 (6) (2012) 1836-1846, http://doi.org/10.1007/s00125-012-2519-z.
DOI Google Scholar
[65]

S. Kim, G.W. Go, J.Y. Imm, Promotion of glucose uptake in C2C12 myotubes by cereal flavone tricin and its underlying molecular mechanism, J. Agric. Food Chem. 65 (19) (2017) 3819-3826, http://doi.org/10.1021/acs.jafc.7b00578.
DOI Google Scholar
[66]

Q.Y. Li, L. Chen, M.M. Yan, Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPAR gamma and IKK/NF-κB signaling, Pharm. Biol. 53 (11) (2015) 1567-1575, http://doi.org/10.3109/13880209.2014.993038.
DOI Google Scholar
[67]

Y. Sakamoto, A. Naka, N. Ohara, et al., Daidzein regulates proinflammatory adipokines thereby improving obesity-related inflammation through PPAR, Mol. Nutr. Food Res. 58 (4) (2014), http://doi.org/10.1002/mnfr.201300482.
DOI Google Scholar
[68]

W.Y. Zhang, J.J. Lee, Y. Kim, et al., Effect of eriodictyol on glucose uptake and insulin resistance in vitro, J. Agric. Food Chem. 60 (31) (2012) 7652-7658, http://doi.org/10.1021/jf300601z.
DOI Google Scholar
[69]

J.Z. Cheng, Z. Cha, H. Xiang, Naringenin alleviated the SH-SY5Y cells death and insulin resistance by activating mTOR/p70S6K signalling pathway in oxidative stress induced by H2O2, J. Chongqing Med. Univ. 44 (4) (2019) 424-429.
Google Scholar
[70]

F. Li, H. Luo, Z.J. Xu, Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism indb/dband diet-induced obese mice, Diabetologia 59 (6) (2020) 1276-1286, http://doi.org/10.1007/s00125-016-3912-9.
DOI Google Scholar
[71]

H.J. Lee, H. Li, M. Noh, Bavachin from Psoralea corylifolia improves insulin-dependent glucose uptake through insulin signaling and AMPK activation in 3T3-L1 adipocytes, Int. J. Mol. Sci. 17 (4) (2016) 527, http://doi.org/10.3390/ijms17040527.
DOI Google Scholar
[72]

W.J. Lee, G. Yoon, M.C. Kim, 5,7-Dihydroxy-6-geranyl flavanone improves insulin sensitivity through PPAR/dual activation, Int. J. Mol. Med. 37 (5) (2016) 1397-1404, http://doi.org/10.3892/ijmm.2016.2531.
DOI Google Scholar
[73]

J.W. Choi, M. Kim, H.D. Song, DMC (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone) improves glucose tolerance as a potent AMPK activator, Metab. -Clin. Exp. 65 (4) (2016) 533-542, http://doi.org/10.1016/j.metabol.2015.12.010.
DOI Google Scholar
[74]

Y.H. Watanabe, Y. Nagai, H. Honda, Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice, Sci. Rep. 6 (2016), http://doi.org/10.1038/srep23097.
DOI Google Scholar
[75]

T. Horiba, I. Nishimura, Y. Nakai, Naringenin chalcone improves adipocyte functions by enhancing adiponectin production, Mol. Cell. Endocrinol. 323 (2) (2010) 208-214, http://doi.org/10.1016/j.mce.2010.03.020.
DOI Google Scholar
[76]

Y. Li, T. Goto, K. Yamakuni, et al., 4-hydroxyderricin, as a PPARγ agonist, promotes adipogenesis, adiponectin secretion, and glucose uptake in 3T3-L1 cells, Lipids 51 (7) (2016) 1-9, http://doi.org/10.1007/s11745-016-4154-9.
DOI Google Scholar
[77]

H.B. Li, Y.R. Yang, Z.J. Mo, Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition, Braz. J. Med. Biol. Res. 48 (5) (2015) 440-446, http://doi.org/10.1590/1414-431X20144238.
DOI Google Scholar
[78]

M. Taher, M. Amiroudine, M. Zakaria, et al., ɑ-Mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells via PPARγ, GLUT4, and leptin expressions, Evid. Based Complement. Altern. Med. 2015 (4) (2015) 1-9, http://doi.org/10.1155/2015/740238.
DOI Google Scholar
[79]

H. Lee, H. Li, J.H. Jeong, Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and A MPK activation in 3T3-L1 adipocytes, Fitoterapia 112 (2016) 90-96, http://doi.org/10.1016/j.fitote.2016.05.006.
DOI Google Scholar
[80]

M. Ueda-wakagi, S. Nishiumi, H. Nagayasu, et al., Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle, Biochem. Biophys. Res. Commun. 377 (1) (2008) 286-290, http://doi.org/10.1039/C8FO00807H.
DOI Google Scholar
[81]

J.M. Peng, Y. Jia, T.Y. Hu, A proanthocyanidin dimer from Camellia ptilophylla, modulates obesity and adipose tissue inflammation in high-fat diet induced obese mice, Mol. Nutr. Food Res. 63 (11) (2019).
DOI Google Scholar
[82]

C.Q.Yang J.H. Xu, D.D. Yan, Mangiferin ameliorates insulin resistance by inhibiting inflammation and regulatiing adipokine expression in adipocytes under hypoxic condition, Chin. J. Nat. Med. 15 (9) (2017) 664-673, http://doi.org/10.1016/S1875-5364(17)30095-X.
DOI Google Scholar
[83]

G. Luan, Y. Wang, Z. Wang, et al., Flavonoid glycosides from fenugreek seeds regulate glycolipid metabolism by improving mitochondrial function in 3T3-L1 adipocytes in vitro, J. Agric. Food Chem. 66 (12) (2018) 3169-3178, http://doi.org/10.1021/acs.jafc.8b00179.
DOI Google Scholar
[84]

Y.M. Tzeng, K. Chen, Y.K. Rao, Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes, Eur. J. Pharmacol. 607 (1) (2009) 27-34, http://doi.org/10.1016/j.ejphar.2009.01.023.
DOI Google Scholar
[85]

L.L. Cui, J.M. Wang, M.K. Wang, et al., Chemical composition and glucose uptake effect on 3T3-L1 adipocytes ofLigustrum lucidum Ait. flowers, Food Sci. Hum. Wellness (2020), http://doi.org/10.1016/j.fshw.2020.02.002.
DOI Google Scholar
[86]
Q.X. Liu, Effects and action mechanism of Daidzin on improving insulin resistance in 3T3-L1 adipocytes, Jinan University, 2014.
[87]

Y. Zhao, Y. Zhou, Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path, Chin. J. Integr. Med. 18 (4) (2012) 293-298, http://doi.org/10.1007/s11655-012-1058-2.
DOI Google Scholar
[88]

H.D. Cai, S.L. Su, S. Guo, et al., Effect of flavonoids from Abelmoschus manihot on proliferation, differentiation of 3T3-L1 preadipocyte and insulin resistance, China J. Chin. Matera Med. 41 (24) (2016) 4635-4641, http://doi.org/10.4268/cjcmm20162424.
DOI Google Scholar
[89]

S.E. Mazibuko, E. Joubert, R. Johnson, et al., Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate, Mol. Nutr. Food Res. 59 (11) (2015) 2199-2208, http://doi.org/10.1002/mnfr.201500258.
DOI Google Scholar
[90]

H.C. Luisa, D.K. Virgínia, F.P. Danielle, et al., Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola, Fitoterapia 83 (7) (2012) 1176-1183, http://doi.org/10.1016/j.fitote.2012.07.003.
DOI Google Scholar
[91]

K.H. Choi, H.A. Lee, M.H. Park, et al., Cyanidin-3-rutinoside increases glucose uptake by activating the PI3K/Akt pathway in 3T3-L1 adipocytes, Environ. Toxicol. Pharmacol. 54 (2017) 1-6, http://doi.org/10.1016/j.etap.2017.06.007.
DOI Google Scholar
[92]

M. Xiong, Y. Huang, Y. Liu, et al., Antidiabetic activity of ergosterol from Pleurotus ostreatus in KK-A(y) mice with spontaneous type 2 diabetes mellitus, Mol. Nutr. Food Res. 62 (3) (2018), http://doi.org/10.1002/mnfr.201700444.
DOI Google Scholar
[93]

K. Mitsuhashi, T. Senmaru, T. Fukuda, et al., Testosterone stimulates glucose uptake and GLUT4 translocation through LKB1/AMPK signaling in 3T3-L1 adipocytes, Endocrine 51 (1) (2016) 174-184, http://doi.org/10.1007/s12020-015-0666-y.
DOI Google Scholar
[94]

T. Takimoto, Y. Kanbayashi, T. Toyoda, 4 beta-Hydroxywithanolide E isolated from Physalis pruinosa calyx decreases inflammatory responses by inhibiting the NF-kappa B signaling in diabetic mouse adipose tissue, Int. J. Obesity 38 (11) (2014) 1432-1439, http://doi.org/10.1038/ijo.2014.33.
DOI Google Scholar
[95]

T. Ito-Nagahata, C. Kurihara, M. Hasebe, et al., Stilbene analogs of resveratrol improve insulin resistance through activation of AMPK, Biosci. Biotechnol. Biochem. 77 (6) (2013) 1229-1235, http://doi.org/10.1271/bbb.121000.
DOI Google Scholar
[96]

C.N.V. Prasad, T. Anjana, A. Banerji, et al., Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells, FEBS Lett. 584 (3) (2010) 531-536, http://doi.org/10.1016/j.febslet.2009.11.092.
DOI Google Scholar
[97]

G. Gandhia, G. Jothib, P. Antonya, et al., Gallic acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARγ in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway, Eur. J. Pharmacol. 745 (2014) 201-216, http://doi.org/10.1016/j.ejphar.2014.10.044.
DOI Google Scholar
[98]

S.M. Park, J.S. Choi, T.G. Nam, Anti-diabetic effect of 3-hydroxy-2-naphthoic acid, an endoplasmic reticulum stress-reducing chemical chaperone, Eur. J. Pharmacol. 779 (2016) 157-167, http://doi.org/10.1016/j.ejphar.2016.03.023.
DOI Google Scholar
[99]

S. Anand, V.S. Muthusamy, S. Sujatha, et al., Aloe emodin glycosides stimulates glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes, FEBS Lett. 584 (14) (2010) 3170-3178, http://doi.org/10.1016/j.febslet.2010.06.004.
DOI Google Scholar
[100]

Y.I. Kim, S.Z. Hirai, T.S. Goto, et al., Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice, PLoS One 7 (2) (2012) 31317, http://doi.org/10.1371/journal.pone.0031317.
DOI Google Scholar
[101]

T.S. Goto, Y.I. Kim, K.F. Funakoshi, Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways, Am. J. Physiol.-Endocrinol. Metab. 301 (5) (2011) 1022-1032, http://doi.org/10.1152/ajpendo.00061.2011.
DOI Google Scholar
[102]

T. Goto, N. Takahashi, S.B. Kato, Bixin activates PPAR alpha and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice, J. Agric. Food Chem. 60 (48) (2012) 11952-11958, http://doi.org/10.1021/jf303639f.
DOI Google Scholar
[103]

B. Huang, H.D. Yuan, K.D. Yeon, Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated receptor-γ (PPARγ) and AMP-activated protein kinase (AMPK) pathways, J. Agric. Food Chem. 59 (8) (2011) 3666-3673, http://doi.org/10.1021/jf104814t.
DOI Google Scholar
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Publication history

Received: 24 December 2019
Revised: 14 February 2020
Accepted: 03 April 2020
Published: 22 April 2020
Issue date: September 2020

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© 2020 "Society information". Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgements

This work was supported by National Natural Science Foundation of China (31900292), Science and Technology Development Program of Henan Province (202102110149, 192102110112, and 182102410083) and Science and Technology Project of Kaifeng (1908005, and 1803010).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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