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Research Article | Open Access

Chemical composition and glucose uptake effect on 3T3-L1 adipocytes of Ligustrum lucidum Ait. flowers

Lili Cuia,1, Jinmei Wanga,b,1, Mengke Wanga,c, Baoguang Wanga,c, Zhenhua Liua,b( ), Jinfeng Weia,b( ), Wenyi Kanga,b( )
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng, 475004, China
Kaifeng Key Laboratory of Functional Components in Health Food, Henan University, Kaifeng, 475004, China
Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Henan University, Kaifeng, 475004, China

1 These authors contributed equally to this work. Peer review under responsibility of KeAi Communications Co., Ltd]]>

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Abstract

Ligustri lucidi Fructus is a traditional Chinese medicine and possesses various bioactivities, including hypoglycemic effect. Ligustrum lucidum Ait flowers are poorly investigated. Thus, we hypothesized that L. lucidum flowers also could have hypoglycemic effect. Chemical composition and glucose uptake effect of L. lucidum flowers on 3T3-L1 adipocytes were investigated. In this study, the components of L. lucidum flowers were investigated by various chromatographic and spectroscopic methods and the effects of L. lucidum flowers on the induction of glucose uptake were investigated by 3T3-L1 adipocytes. Seven compounds were isolated and identified from L. lucidum flowers, including ursolic acid (1), kaempferol-7-O-α-L-rhamnoside (2, KR), β-sitosterol (3), β-daucosterol (4), kaempferitrin (5, KF), 10-hydroxy oleuropein (6, HO), and kaempferol-3-O-β-D-glucopyranoside-7-α-L-rhamnopyranoside (7, KGR). The results of glucose uptake showed that total extract (TE), KR, KF and HO from L. lucidum flowers significantly enhanced glucose uptake. This study demonstrated that compounds 2, 5-7 were isolated for the first time from this plant and compounds 2 and 7 were isolated for the first time in genus Ligustrum, L. lucidum flowers, KR, KF and HO may possess potential hypoglycemic effect.

Keywords

Ligustrum lucidum flowersChemical composition3T3-L1 adipocytes

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Food Science and Human Wellness
Volume 9 Issue 2,
June 2020
Pages 124-129
DOI: 10.1016/j.fshw.2020.02.002
Cite this article:
Cui L, Wang J, Wang M, et al. Chemical composition and glucose uptake effect on 3T3-L1 adipocytes of Ligustrum lucidum Ait. flowers. Food Science and Human Wellness, 2020, 9(2): 124-129. https://doi.org/10.1016/j.fshw.2020.02.002

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Received: 15 December 2019
Revised: 23 January 2020
Accepted: 04 February 2020
Published: 05 February 2020
© 2020 "Society information". Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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