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Research Article | Open Access

Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice

Jia-Ni Lina,1, Pei-Sheng Leea,1, Nai-Wen Meib, An-Chin Chengc, Roch-Chui Yua, Min-Hsiung Pana,d,e( )
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, China
GINCARE Int'l Enterprises Co., Ltd., No. 24, Sec. 3, Chungyang Rd., Tu-Cheng Dist., New Taipei City, 23673, Taiwan, China
Department of Tourism, Food and Beverage Management, Chang Jung Christian University, Tainan 71101, Taiwan, China
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, China
Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, China

1 These authors contributed equally to this study.

Peer review under responsibility of KeAi Communications Co., Ltd

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Abstract

Excess caloric intake increases the amount of adipose tissue and contributes to metabolic disorders in disrupted metabolic homeostasis. This study aimed to investigate the anti-obesity effects of ginseng and the alternation of gut microbiota composition in high-fat diet (HFD)-induced obesity. The results showed that HFD treatment influenced body weight gain, adipose tissue accumulation and biochemical parameter changes. Compared to the HFD group, ginseng supplementation of HFD-fed mice decreased body weight, adipose tissue mass, total cholesterol (T-CHO) and high-density lipoprotein (HDL)/low-density lipoprotein (LDL) ratio. To analysis the alterations of gut microbiota, ginseng in dietary supplements decreased Firmicutes abundance and increased Bacteroidetes abundance. Taken together, these findings suggest ginseng may modulate the energy storage and alter gut microbiota composition.

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Food Science and Human Wellness
Pages 344-350

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Cite this article:
Lin J-N, Lee P-S, Mei N-W, et al. Effects of ginseng dietary supplementation on a high-Fat diet-induced obesity in C57BL/6 Mice. Food Science and Human Wellness, 2019, 8(4): 344-350. https://doi.org/10.1016/j.fshw.2019.01.004

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Received: 25 November 2018
Accepted: 11 January 2019
Published: 16 November 2019
© 2019 “Society information”.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).