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Genetically modified foods: A critical review of their promise and problems
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The term “genetic modified organisms (GMO)” has become a controversial topic as its benefits for both food producers and consumers are companied by potential biomedical risks and environmental side effects. Increasing concerns from the public about GMO, particularly in the form of genetic modified (GM) foods, are aimed at the short- and long-lasting health problems that may result from this advanced biotechnology. Complex studies are being carried out around the world independently to evaluate the advantages and disadvantages of GM foods. In this paper, we attempt to summarize up-to-date knowledge about the benefits and potential problems of GM food. We also introduce some recent technological developments in GM foods and their impact in the field.
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Genetically modified foods: A critical review of their promise and problems
),
Abstract
The term “genetic modified organisms (GMO)” has become a controversial topic as its benefits for both food producers and consumers are companied by potential biomedical risks and environmental side effects. Increasing concerns from the public about GMO, particularly in the form of genetic modified (GM) foods, are aimed at the short- and long-lasting health problems that may result from this advanced biotechnology. Complex studies are being carried out around the world independently to evaluate the advantages and disadvantages of GM foods. In this paper, we attempt to summarize up-to-date knowledge about the benefits and potential problems of GM food. We also introduce some recent technological developments in GM foods and their impact in the field.
References(43)
M.J. Oliver, Why we need GMO crops in agriculture, MO Med. 111 (6) (2014) 492-507.
O.T. Avery, C.M. Macleod, M. McCarty, Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a deoxyribonucleic acid fraction isolated from pneumococcus type III, J. Exp. Med. 79 (2) (1944) 137-158.
M.W. Nirenberg, J.H. Matthaei, O.W. Jones, R.G. Martin, S.H. Barondes, Approximation of genetic code via cell-free protein synthesis directed by template RNA, Fed. Proc. 22 (1963) 55-61.
S.N. Cohen, A.C. Chang, H.W. Boyer, R.B. Helling, Construction of biologically functional bacterial plasmids in vitro, Proc. Natl. Acad. Sci. U.S.A. 70 (11) (1973) 3240-3244.
M.W. Bevan, M.D. Chilton, Multiple transcripts of T-DNA detected in nopaline crown gall tumors, J. Mol. Appl. Genet. 1 (6) (1982) 539-546.
R.T. Fraley, Liposome-mediated delivery of tobacco mosaic virus RNA into petunia protoplast: improved conditions for liposome-protoplast incubations, Plant Mol. Biol. 2 (1) (1983) 5-14.
L. Herrera-Estrella, M.D. Block, E. Messens, J.P. Hernalsteens, M.V. Montagu, J. Schell, Chimeric genes as dominant selectable markers in plant cells, EMBO J. 2 (6) (1983) 987-995.
A.S. Bawa, K.R. Anilakumar, Genetically modified foods: safety risks and public concerns-a review, J. Food Sci. Technol. 50 (6) (2013) 1035-1046.
D.K. Ray, N.D. Mueller, P.C. West, J.A. Foley, Yield trends are insufficient to double global crop production by 2050, PLOS ONE 8 (6) (2013) e66428.
J.C. Sanford, Biolistic plant transformation, Physiol. Plant. 79 (1) (1990) 206-209.
S. Barampuram, Z.J. Zhang, Recent advances in plant transformation, Methods Mol. Biol. 701 (2011) 1-35.
M.A. Schmidt, P.R. LaFayette, B.A. Artelt, W.A. Parrott, A comparison of strategies for transformation with multiple genes via microprojectile-mediated bombardment, In Vitro Cell Dev. Biol. Plant 44 (3) (2008) 162-168.
L. Cong, F.A. Ran, D. Cox, S. Lin, R. Barretto, N. Habib, P.D. Hsu, X. Wu, W. Jiang, L.A. Marraffini, et al., Multiplex genome engineering using CRISPR/Cas systems, Science 339 (6121) (2013) 819-823.
F.A. Ran, P.D. Hsu, J. Wright, V. Agarwala, D.A. Scott, F. Zhang, Genome engineering using the CRISPR-Cas9 system, Nat. Protocols 8 (11) (2013) 2281-2308.
F.J. DeMayo, T.E. Spencer, CRISPR bacon: a sizzling technique to generate genetically engineered pigs, Biol. Reprod. 91 (3) (2014) 79.
G. Brookes, P. Barfoot, Economic impact of GM crops: the global income and production effects 1996–2012, GM Crops Food 5 (1) (2014) 65-75.
J. Schell, M. Van Montagu, The Ti-plasmid of Agrobacterium tumefaciens, a natural vector for the introduction of NIF genes in plants?, Basic Life Sci. 9 (1977) 159-179.
A. Rizzi, N. Raddadi, C. Sorlini, L. Nordgrd, K.M. Nielsen, D. Daffonchio, The stability and degradation of dietary DNA in the gastrointestinal tract of mammals: implications for horizontal gene transfer and the biosafety of GMOs, Crit. Rev. Food Sci. Nutr. 52 (2) (2012) 142-161.
M.A.L. Schmidt, P.R. Artelt, B.A.W.A. Parrott, A comparison of strategies for transformation with multiplegenes via microprojectile-mediated bombardment, In Vitro Cell Dev. Biol. Plant 44 (2008) 162-168.
M. Kramkowska, T. Grzelak, K. Czyzewska, Benefits and risks associated with genetically modified food products, Ann. Agric. Environ. Med. 20 (3) (2013) 413-419.
J.V. Oakes, C.K. Shewmaker, D.M. Stalker, Production of cyclodextrins, a novel carbohydrate, in the tubers of transgenic potato plants, Biotechnology 9 (10) (1991) 982-986.
A. Nicolia, A. Manzo, F. Veronesi, D. Rosellini, An overview of the last 10 years of genetically engineered crop safety research, Crit. Rev. Biotechnol. 34 (1) (2014) 77-88.
N.P.H. Ellstrand, J.F. Hancock, Gene flow and introgression from domesticated plants into their wild relatives, Annu. Rev. Ecol. Syst. 30 (1999) 539-563.
B.E. Tabashnik, Evolution of resistance to Bacillus thuringiensis, Annu. Rev. Entomol. 39 (1994) 47-79.
S. Chandler, J.M. Dunwell, Gene flow, risk assessment and the environmental release of transgenic plants, Crit. Rev. Plant Sci. 27 (1) (2008) 25-49.
P.D. Hare, N.H. Chua, Excision of selectable marker genes from transgenic plants, Nat. Biotechnol. 20 (6) (2002) 575-580.
M.G. Schafer, A.A. Ross, J.P. Londo, C.A. Burdick, E.H. Lee, S.E. Travers, P.K. Van de Water, C.L. Sagers, The establishment of genetically engineered canola populations in the US, PLoS ONE 6 (10) (2011).
S. Aggarwal, What's fueling the biotech engine – 2011 to 2012, Nat. Biotechnol. 30 (12) (2012) 1191-1197.
J.R. Reichman, L.S. Watrud, E.H. Lee, C.A. Burdick, M.A. Bollman, M.J. Storm, G.A. King, C. Mallory-Smith, Establishment of transgenic herbicide-resistant creeping bentgrass (Agrostis stolonifera L.) in nonagronomic habitats, Mol. Ecol. 15 (13) (2006) 4243-4255.
D.J. Gibson, K.L. Gage, J.L. Matthews, B.G. Young, M.D.K. Owen, R.G. Wilson, S.C. Weller, D.R. Shaw, D.L. Jordan, The effect of weed management systems and location on arable weed species communities in glyphosate-resistant cropping systems, Appl. Veg. Sci. 16 (4) (2013).
J. Werth, L. Boucher, D. Thornby, S. Walker, G. Charles, Changes in weed species since the introduction of glyphosate-resistant cotton, Crop Pasture Sci. 64 (8) (2013) 791-798.
A. Bravo, S.S. Gill, M. Soberon, Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control, Toxicon 49 (4) (2007) 423-435.
V. Sanchis, From microbial sprays to insect-resistant transgenic plants: history of the biopesticide Bacillus thuringiensis. A review, Agron. Sustain. Dev. 31 (1) (2011) 217-231.
A.A. Snow, P.M. Palma, Commercialization of transgenic plants: potential ecological risks, Bioscience 47 (2) (1997) 86-96.
D.K. Ray, N. Ramankutty, N.D. Mueller, P.C. West, J.A. Foley, Recent patterns of crop yield growth and stagnation, Nat. Commun. 3 (2012).
A.E. Ricroch, J.B. Berge, M. Kuntz, Evaluation of genetically engineered crops using transcriptomic, proteomic, and metabolomic profiling techniques, Plant Physiol. 155 (4) (2011) 1752-1761.
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