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Moringa oleifera, native to India, grows in the tropical and subtropical regions of the world. It is commonly known as ‘drumstick tree’ or ‘horseradish tree’. Moringa can withstand both severe drought and mild frost conditions and hence widely cultivated across the world. With its high nutritive values, every part of the tree is suitable for either nutritional or commercial purposes. The leaves are rich in minerals, vitamins and other essential phytochemicals. Extracts from the leaves are used to treat malnutrition, augment breast milk in lactating mothers. It is used as potential antioxidant, anticancer, anti-inflammatory, antidiabetic and antimicrobial agent. M. oleifera seed, a natural coagulant is extensively used in water treatment. The scientific effort of this research provides insights on the use of moringa as a cure for diabetes and cancer and fortification of moringa in commercial products. This review explores the use of moringa across disciplines for its medicinal value and deals with cultivation, nutrition, commercial and prominent pharmacological properties of this “Miracle Tree”.


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Moringa oleifera: A review on nutritive importance and its medicinal application

Show Author's information Lakshmipriya GopalakrishnanbKruthi DoriyaaDevarai Santhosh Kumara( )
Department of Chemical Engineering, Ordnance Factory Estate, Yeddumailaram, Indian Institute of Technology Hyderabad, Telangana, India
Department of Biotechnology, PES University, Bangalore, India

Peer review under responsibility of Beijing Academy of Food Sciences.

Abstract

Moringa oleifera, native to India, grows in the tropical and subtropical regions of the world. It is commonly known as ‘drumstick tree’ or ‘horseradish tree’. Moringa can withstand both severe drought and mild frost conditions and hence widely cultivated across the world. With its high nutritive values, every part of the tree is suitable for either nutritional or commercial purposes. The leaves are rich in minerals, vitamins and other essential phytochemicals. Extracts from the leaves are used to treat malnutrition, augment breast milk in lactating mothers. It is used as potential antioxidant, anticancer, anti-inflammatory, antidiabetic and antimicrobial agent. M. oleifera seed, a natural coagulant is extensively used in water treatment. The scientific effort of this research provides insights on the use of moringa as a cure for diabetes and cancer and fortification of moringa in commercial products. This review explores the use of moringa across disciplines for its medicinal value and deals with cultivation, nutrition, commercial and prominent pharmacological properties of this “Miracle Tree”.

Keywords: Antidiabetic, Anticancer, Moringa oleifera, Miracle Tree, Coagulant

References(70)

[1]

J.L. Rockwood, B.G. Anderson, D.A. Casamatta, Potential uses of Moringa oleifera and an examination of antibiotic efficacy conferred by M. oleifera seed and leaf extracts using crude extraction techniques available to underserved indigenous populations, Int. J. Phytothearpy Res. 3 (2013) 61-71.

[2]

J.N. Kasolo, G.S. Bimenya, L. Ojok, J. Ochieng, J.W. Ogwal-okeng, Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities, J. Med. Plants Res. 4 (2010) 753-757.

[3]

T. Mutiara Titi, E.S.W. Estiasih, Effect lactagogue moringa leaves (Moringa oleifera Lam) powder in rats, J. Basic Appl. Sci. Res. 3 (2013) 430-434.

[4]

M.D. Thurber, J.W. Fahey, Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the diffusion of innovations theory, Ecol. Food Sci. Nutr. 48 (2010) 1-13.

[5]

M.F. Aslam, R. Anwar, U. Nadeem, T.G. Rashid, A. Kazi, M. Nadeem, Mineral composition of Moringa oleifera leaves and pods from different regions of Punjab, Pakistan, Asian J. Plant Sci. 4 (2005) 417-421.

[6]

W.J. Asante, I.L. Nasare, D. Tom-Dery, K. Ochire-Boadu, K.B. Kentil, Nutrient composition of Moringa oleifera leaves from two agro ecological zones in Ghana, African J. Plant 8 (2014) 65-71.

[7]

S.O. Dania, P. Akpansubi, O.O. Eghagara, Comparative Effects of different fertilizer sources on the growth and nutrient content of moringa (Moringa oleifera) seedling in a greenhouse trial, Pharma. Clin. Res. 5 (2014) 67-72.

[8]

M. Mbikay, Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: a review, Front. Pharmacol. 3 (2012) 1-12.

[9]

L. Berkovich, G. Earon, I. Ron, A. Rimmon, A. Vexler, S. Lev-Ari, Moringa oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells, BMC Complement. Altern. Med. 13 (2013) 212-219.

[10]

I. Oduro, W.O. Ellis, D. Owusu, Nutritional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves, Sci. Res. Essays 3 (2008) 57-60.

[11]

D.I. Sánchez-Machado, J.A. Núñez-Gastélum, C. Reyes-Moreno, B. Ramírez-Wong, J. López-Cervantes, Nutritional quality of edible parts of Moringa oleifera, Food Anal. Methods 3 (2010) 175-180.

[12]
L.J. Fuglie, The Moringa Tree: A local solution to malnutrition Church World Service in Senegal, 2005.
[13]

J.T. Barminas, M. Charles, D. Emmanuel, Mineral composition of non-conventional leafy vegetables, Plant Foods Hum. Nutr. 53 (1998) 29-36.

[14]

S. Lalas, J. Tsaknis, Characterization of Moringa oleifera seed oil variety Periyakulam-1, J. Food Compos. Anal. 15 (2002) 65-77.

[15]

R. Yang, L. Chang, J. Hsu, B.B.C. Weng, C. Palada, M.L. Chadha, V. Levasseur, Nutritional and functional properties of moringa leaves from germplasm, to plant, to food, to health, Am. Chem. Soc. (2006) 1-17.

[16]

B. Moyo, P. Masika, A. Hugo, V. Muchenje, Nutritional characterization of Moringa (Moringa oleifera Lam.) leaves, African J. Biotechnol. 10 (2011) 12925-12933.

[17]

O.S. Ijarotimi, O. Adeoti, O. Ariyo, Comparative study on nutrient composition, phytochemical, and functional characteristics of raw, germinated, and fermented Moringa oleifera seed flour, Food Sci. Nutr. 1 (2013) 452-463.

[18]

B. Sallau, S.B. Mada, S. Ibrahim, U. Ibrahim, Effect of boiling, simmering and blanching on the antinutritional content of Moringa oleifera leaves, Int. J. Food Nutr. Saf. 2 (2012) 1-6.

[19]

T.M. Kiranawati, N. Nurjanah, Improvement of noodles recipe for increasing breastmilk: design of the Moringa noodles, Am. J. Food Sci. Technol. 2 (2014) 88-92.

[20]

A.A. Abou-zaid, A.S. Nadir, Quality evaluation of nutritious chocolate and halawa tahinia produced with moringa (Moringa oleifera) leaves powder, Middle East J. Appl. Sci. 4 (2014) 1007-1015.

[21]

I.J. Asiedu-Gyekye, S. Frimpong-Manso, C. Awortwe, D.A. Antwi, A.K. Nyarko, Micro- and macroelemental composition and safety evaluation of the nutraceutical Moringa oleifera leaves, J. Toxicol. 2014 (2014) 1-13.

[22]

M.E. Cerf, Beta cell dysfunction and insulin resistance, Front. Endocrinol. 4 (2013) 1-12.

[23]

S.M. Divi, R. Bellamkonda, S.K. Dasireddy, Evaluation of antidiabetic and antihyperlipedemic potential of aqueous extract of Moringa oleifera in fructose fed insulin resistant and STZ induced diabetic wistar rats: a comparative study, Asian J. Pharm. Clin. Res. 5 (2012) 67-72.

[24]

E. Wright, J.L. Scism-Bacon, L.C. Glass, Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia, Int. J. Clin. Pract. 60 (2006) 308-314.

[25]

H. Kaneto, Y. Kajimoto, J. Miyagawa, T. Matsuoka, Y. Fujitani, Y. Umayahara, T. Hanafusa, Y. Matsuzawa, Y. Yamasaki, M. Hori, Beneficial effects of antioxidants in diabetes: possible protection of pancreatic β-cells against glucose toxicity, Diabetes 48 (1999) 2398-2406.

[26]

M. Prentki, C.J. Nolan, Islet β cell failure in type 2 diabetes, J. Clin. Invest. 116 (2006) 1802-1812.

[27]

N. Kamalakkannan, P.S.M. Prince, Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats, Basic Clin. Pharmacol. Toxicol. 98 (2006) 97-103.

[28]

D. Aronson, E.J. Rayfield, How hyperglycemia promotes atherosclerosis: molecular mechanisms, Cardiovasc. Diabetol. 1 (2002) 1.

[29]

P. Chumark, P. Khunawat, Y. Sanvarinda, S. Phornchirasilp, N.P. Morales, L. Phivthongngam, P. Ratanchamnong, S. Srisawat, K.U. Pongrapeeporn, The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves, J. Ethnopharmacol. 116 (2008) 439-446.

[30]

C. Tiloke, A. Phulukdaree, A.A. Chuturgoon, The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on cancerous human alveolar epithelial cells, BMC Complement. Altern. Med. 13 (2013) 226-233.

[31]

I.L. Jung, Soluble extract from Moringa oleifera leaves with a new anticancer activity, PLOS ONE 9 (2014) 1-10.

[32]

G.Y. Liou, P. Storz, Reactive oxygen species in cancer, Free Radic. Res. 44 (2010) 479-496.

[33]

A. Hermawan, K.A. Nur, Sarmoko, D. Dewi, P. Putri, E. Meiyanto, Ethanolic extract of Moringa oleifera increased cytotoxic effect of doxorubicin on HeLa cancer cells, J. Nat. Remedies 12 (2012) 108-114.

[34]

Y. Nakamura, M. Kawakami, A. Yoshihiro, N. Miyoshi, H. Ohigashi, K. Kawai, et al., Involvement of the mitochondrial death pathway in chemo preventive benzyl isothiocyanate-induced apoptosis, J. Biol. Chem. 277 (2002) 8492-8499.

[35]

N. Miyoshi, K. Uchida, T. Osawa, Y. Nakamura, A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation, Cancer Res. 64 (2004) 2134-2142.

[36]

K. Baker, C.B. Marcus, K. Huffman, H. Kruk, B. Malfroy, S.R. Doctrow, Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury, J. Pharmacol. Exp. Ther. 284 (1998) 215-221.

[37]

W. Kirisattayakul, J. Wattanathorn, T. Tong-Un, S. Muchimapura, P. Wannanon, J. Jittiwat, Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion, Oxid. Med. Cell. Longev. 2013 (2013) 10-13.

[38]

C. Sutalangka, J. Wattanathorn, S. Muchimapura, W. Thukham-mee, Moringa oleifera mitigates memory impairment and neurodegeneration in animal model of age-related dementia, Oxid. Med. Cell. Longev. 2013 (2013) 1-9.

[39]

O.S. Adeyemi, T.C. Elebiyo, Moringa oleifera supplemented diets prevented nickel-induced nephrotoxicity in Wistar rats, J. Nutr. Metab. 2014 (2014) 1-8.

[40]

M.K. Choudhary, S.H. Bodakhe, S.K. Gupta, Assessment of the antiulcer potential of Moringa oleifera root-bark extract in rats, JAMS J. Acupunct. Meridian Stud. 6 (2013) 214-220.

[41]

T.G. Monera, C.C. Maponga, Prevalence and patterns of Moringa oleifera use among HIV positive patients in Zimbabwe: a cross-sectional survey, J. Public Health Africa 3 (2012) 6-8.

[42]

G.S. Mahajan, A.A. Mehta, Anti-arthritic activity of hydroalcoholic extract of flowers of Moringa oleifera lam. in Wistar rats, J. Herbs Spices Med. Plants 15 (2009) 149-163.

[43]

G.H.F. Viera, J.A. Mourão, Â.M. Ângelo, R.A. Costa, R.H.S.D.F. Vieira, Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria, Rev. Inst. Med. Trop. Sao Paulo 52 (2010) 129-132.

[44]

J. Fahey, Moringa oleifera: a review of the medical evidence for its nutritional, therapeutic, and prophylactic properties, Trees Life J. 1 (2005) 1-33.

[45]

S. Suhartini, N. Hidayat, E. Rosaliana, Influence of powdered Moringa oleifera seeds and natural filter media on the characteristics of tapioca starch wastewater, Int. J. Recycl. Org. Waste Agric. 2 (2013) 1-11.

[46]

K. Ravikumar, A.K. Sheeja, Heavy metal removal from water using Moringa oleifera seed coagulant and double filtration, Int. J. Sci. Eng. Res. 4 (2013) 10-13.

[47]

O. Aluko, M.R. Brai, A.O. Adelore, Materials evaluation of sensory attributes of snack from maize-moringa seed flour blends, Int. J. Innov. Res. Sci. Eng. Technol. 7 (2013) 597-599.

[48]

I.O. Steve, O.I. Babatunde, Chemical compositions and nutritional properties of popcorn-based complementary foods supplemented with Moringa oleifera, Leaves Flour 2 (2013) 117-132.

[49]

D. Owusu, I. Oduro, Development of crackers from cassava and sweetpotato flours using Moringa oleifera and Ipomoea batatas leaves as fortificant, Am. J. Food Nutr. 1 (2011) 114-122.

[50]

A.L. Al-Malki, H.A. El Rabey, The antidiabetic effect of low doses of Moringa oleifera Lam. seeds on streptozotocin induced diabetes and diabetic nephropathy in male rats, Biomed. Res. Int. 2015 (2015) 1-13.

[51]

O.E. Adejumo, A.L. Kolapo, A.O. Folarin, Moringa oleifera Lam. (Moringaceae) grown in Nigeria: in vitro antisickling activity on deoxygenated erythrocyte cells, J. Pharm. Bioall. Sci. 4 (2012) 118-122.

[52]

P.T. Olagbemide, P.C. Alikwe, Proximate analysis and chemical composition of raw and defatted Moringa oleifera kernel, Adv. Life Sci. Technol. 24 (2014) 92-99.

[53]

M. Lurling, W. Beekman, Anticyanobacterial activity of Moringa oleifera seeds, J. Appl. Phycol. 23 (2010) 503-510.

[54]

L.P. Shank, T. Riyathong, V.S. Lee, S. Dheeranupattana, Peroxidase activity in native and callus culture of Moringa oleifera Lam, J. Med. Bioeng. 2 (2013) 163-167.

[55]

T.R. Santos, M.F. Silva, L. Nishi, A.M. Vieira, M.R. Klein, M.B. Andrade, M.F. Vieira, R. Bergamasco, Development of a magnetic coagulant based on Moringa oleifera seed extract for water treatment, Env. Sci. Pollut. Res. (2016) 1-9.

[56]

K.J. Raphaël, Effects of substituting soybean with Moringa oleifera meal in diets on laying and eggs quality characteristics of KABIR chickens, J. Anim. Nutr. 1 (2015) 1-6.

[57]

T.S. Olugbemi, S.K. Mutayoba, F.P. Lekule, Effect of Moringa (M. oleifera) inclusion in cassava based diets fed to broiler chickens, Int. J. Poult. Sci. 9 (2010) 363-367.

[58]

M.E. Sengupta, B. Keraita, A. Olsen, O.K. Boateng, S.M. Thamsborg, G.R. Pálsdóttir, A. Dalsgaard, Use of Moringa oleifera seed extracts to reduce helminth egg numbers and turbidity in irrigation water, Water Res. 46 (2012) 3646-3656.

[59]

S.P. Mishra, P. Singh, S. Singh, Processing of Moringa oleifera leaves for human consumption, Bull. Environ. Pharmacol. Life Sci. 2 (2012) 28-31.

[60]
Moringa Leaf Powder: A nutritional analysis of leaf powder. http://www.moringaleafpowder.co.za/analysis.html.
[61]

S. Nair, K.N. Varalakshmi, Anticancer, cytotoxic potential of Moringa oleifera extracts on HeLa cell line, J. Nat. Pharm. 2 (2011) 138-142.

[62]

I. Oduro, W.O. Ellis, D. Owusu, Nutriional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves, Sci. Res. Essays 3 (2008) 57-60.

[63]

F. Kachik, B.G. Mudlagiri, R.B. Gary, H. Joanne, W.R. Lusby, D.T. Maria, M.R. Barrera, Effects of food preparation on qualitative and quantitative distribution of major carotenoids constituents of tomatoes and several green vegetables, J. Agric. Food Chem. 40 (1992) 390-398.

[64]

S. Leelawat, K. Leelawat, Moringa olefiera extracts induce cholangiocarcinoma cell apoptosis by induction of reactive oxygen species production, Int. J. Pharmacogn. Phytochem. Res. 6 (2014) 183-189.

[65]

Y.J. Lee, E. Shacter, Oxidative stress inhibits apoptosis in human lymphoma cells, J. Biol. Chem. 274 (1999) 19792-19798.

[66]

M. Chen, R.P. Verdes, Elucidation of bactericidal effects incurred by Moringa oleifera and Chitosan, J US SJWP 4 (2009) 65-79.

[67]

S.A. Jahn, H.A. Musnad, H. Burgstaller, The tree that purifies water: cultivating multipurpose Moringaceae in the Sudan, Unasylva 38 (1986) 23-28.

[68]

A.K. Arise, R.O. Arise, M.O. Sanusi, O.T. Esan, S.A. Oyeyinka, Effect of Moringa oleifera flower fortification on the nutritional quality and sensory properties of weaning food, Croat. J. Food Sci. Technol. 6 (2014) 65-71.

[69]

M.K. Nair, C. Varghese, R. Swaminathan, Cancer current scenario, intervention strategies and projections for 2015, Burd. Dis. India (2005) 219-225.

[70]

V.S. Nambiar, S. Parnami, Standardization and organoleptic evaluation of drumstick (Moringa oleifera) leaves incorporated into traditional Indian recipes, Trees 3 (2008) 1-7.

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Received: 02 January 2016
Revised: 23 February 2016
Accepted: 03 April 2016
Published: 11 April 2016
Issue date: June 2016

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© 2016 Beijing Academy of Food Sciences.

Acknowledgements

Acknowledgements

The authors sincerely thank Director Indian Institute of Technology Hyderabad for their continued encouragement and support. LG thanks DSK for constant support and valuable suggestions in completing this manuscript.

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