Journal Home > Volume 6 , Issue 5
Biophysics Reports 2020, 6(5): 193-210 https://doi.org/10.1007/s41048-020-00117-8
Review | Open Access | Issue | Published: 06 October 2020

Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy

Show Author's Information Yingsi Xie1,3,,  Ruslan G. Tuguntaev1,,  Cong Mao1,  Haoting Chen1,  Ying Tao1,  Shixiang Wang4( ),  Bin Yang2( ),  Weisheng Guo1( )
Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
The Sixth Affiliated Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China
Université Paris 13, 99 avenue Jean Baptiste Clément, 93430 Villetaneuse, France
Department of Cardiovascular Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China

Yingsi Xie and Ruslan G. Tuguntaev contributed equally to this work.

Keywords:
Drug delivery systems, Nanotechnology, Rheumatoid arthritis, Stimuli-responsive polymers
Cite this article:
Xie Y, Tuguntaev RG, Mao C, et al. Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy. Biophysics Reports, 2020, 6(5): 193-210. https://doi.org/10.1007/s41048-020-00117-8
Download citation
EndNote(RIS)
BibTeX

181

Views

10

Downloads

Citations

10

Crossref

N/A

WoS

0

Scopus

0

CSCD

Abstract Full text About this article

Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.


menu
Abstract
Full text
Outline
About this article

Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy

Show Author's information Yingsi Xie1,3,, Ruslan G. Tuguntaev1,, Cong Mao1, Haoting Chen1, Ying Tao1, Shixiang Wang4( ), Bin Yang2( ), Weisheng Guo1( )
Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
The Sixth Affiliated Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China
Université Paris 13, 99 avenue Jean Baptiste Clément, 93430 Villetaneuse, France
Department of Cardiovascular Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China

Yingsi Xie and Ruslan G. Tuguntaev contributed equally to this work.

Abstract

Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.

Keywords: Drug delivery systems, Nanotechnology, Rheumatoid arthritis, Stimuli-responsive polymers

References(104)

Abbas M, Monireh M, (2008) The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.Iran J Allergy Asthma Immunol 7(4):195-202
Google Scholar

Alam MM, Han HS, Sung S, Kang JH, Sa KH, Al Faruque H, Hong J, Nam EJ, San Kim I, Park JH, (2017) Endogenous inspired biomineral-installed hyaluronan nanoparticles as pH-responsive carrier of methotrexate for rheumatoid arthritis.J Control Release 252:62-72
DOI Google Scholar

Albinali KE, Zagho MM, Deng Y, Elzatahry AA, (2019) A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems.Int J Nanomed 14:1707
DOI Google Scholar

Aletaha D, Smolen JS, (2018) Diagnosis and management of rheumatoid arthritis: a review.JAMA 320(13):1360-1372
DOI Google Scholar

Arias JL, López-Viota M, López-Viota J, Delgado ÁV, (2009) Development of iron/ethylcellulose (core/shell) nanoparticles loaded with diclofenac sodium for arthritis treatment.Int J Pharm 382(1–2):270-276
DOI Google Scholar

Baeza A, Guisasola E, Ruiz-Hernandez E, Vallet-Regí M, (2012) Magnetically triggered multidrug release by hybrid mesoporous silica nanoparticles.Chem Mater 24(3):517-524
DOI Google Scholar

Behrens MA, Bergenholtz J, Pedersen JS, (2014) Temperature-Induced attractive interactions of PEO-containing block copolymer micelles.Langmuir 30(21):6021-6029
DOI Google Scholar

Beija M, Marty J-D, Destarac M, (2011) Thermoresponsive poly (N-vinyl caprolactam)-coated gold nanoparticles: sharp reversible response and easy tunability.Chem Commun 47(10):2826-2828
DOI Google Scholar

Borregaard N, Herlin T, (1982) Energy metabolism of human neutrophils during phagocytosis.J Clin Investig 70(3):550-557
DOI Google Scholar

Boyer C, Liu J, Bulmus V, Davis TP, (2009) RAFT polymer end-group modification and chain coupling/conjugation via disulfide bonds.Aust J Chem 62(8):830-847
DOI Google Scholar

Chatterjee S, Hui C-L, (2019) Review of stimuli-responsive polymers in drug delivery and textile application.Molecules 24(14):2547
DOI Google Scholar

Chen M-C, Mi F-L, Liao Z-X, Hsiao C-W, Sonaje K, Chung M-F, Hsu L-W, Sung H-W, (2013) Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules.Adv Drug Deliv Rev 65(6):865-879
DOI Google Scholar

Chen B, Zhang Y, Ran R, Wang B, Qin F, Zhang T, Wan G, Chen H, Wang Y, (2019) Reactive oxygen species-responsive nanoparticles based on a thioketal-containing poly (β-amino ester) for combining photothermal/photodynamic therapy and chemotherapy.Polym Chem 10(34):4746-4757
DOI Google Scholar

Chen M, Amerigos JCK, Su Z, Guissi NEI, Xiao Y, Zong L, Ping Q, (2019) Folate receptor-targeting and reactive oxygen species-responsive liposomal formulation of methotrexate for treatment of rheumatoid arthritis.Pharmaceutics 11(11):582
DOI Google Scholar

Cui W, Lu X, Cui K, Wu J, Wei Y, Lu Q, (2011) Photosensitive nanoparticles of chitosan complex for controlled release of dye molecules.Nanotechnology 22(6):065702
DOI Google Scholar

Cui W, Lu X, Cui K, Niu L, Wei Y, Lu Q, (2012) Dual-responsive controlled drug delivery based on ionically assembled nanoparticles.Langmuir 28(25):9413-9420
DOI Google Scholar

Dai J, Lin S, Cheng D, Zou S, Shuai X, (2011) Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release.Angew Chem Int Ed 50(40):9404-9408
DOI Google Scholar

De La Rica R, Aili D, Stevens MM, (2012) Enzyme-responsive nanoparticles for drug release and diagnostics.Adv Drug Deliv Rev 64(11):967-978
DOI Google Scholar

Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM, (2017) Genetic and environmental risk factors for rheumatoid arthritis.Best Pract Res Clin Rheumatol 31(1):3-18
DOI Google Scholar

Duong HT, Jung K, Kutty SK, Agustina S, Adnan NNM, Basuki JS, Kumar N, Davis TP, Barraud N, Boyer C, (2014) Nanoparticle (star polymer) delivery of nitric oxide effectively negates Pseudomonas aeruginosa biofilm formation.Biomacromol 15(7):2583-2589
DOI Google Scholar

Elluru M, Ma H, Hadjiargyrou M, Hsiao BS, Chu B, (2013) Synthesis and characterization of biocompatible hydrogel using Pluronics-based block copolymers.Polymer 54(8):2088-2095
DOI Google Scholar

Fang W, Yang J, Gong J, Zheng N, (2012) Photo-and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@ Ag nanoparticles.Adv Funct Mater 22(4):842-848
DOI Google Scholar

Farr M, Garvey K, Bold A, Kendall M, Bacon P, (1985) Significance of the hydrogen ion concentration in synovial fluid.Clin Exp Rheumatol 3:99-104
Google Scholar

Firestein GS, McInnes IB, (2017) Immunopathogenesis of rheumatoid arthritis.Immunity 46(2):183-196
DOI Google Scholar

Fomina N, McFearin C, Sermsakdi M, Edigin O, Almutairi A, (2010) UV and near-IR triggered release from polymeric nanoparticles.J Am Chem Soc 132(28):9540-9542
DOI Google Scholar

Fomina N, McFearin CL, Sermsakdi M, Morachis JM, Almutairi A, (2011) Low power, biologically benign NIR light triggers polymer disassembly.Macromolecules 44(21):8590-8597
DOI Google Scholar

Fonseca LJS, Nunes-Souza V, Goulart MOF, Rabelo LA, (2019) Oxidative stress in rheumatoid arthritis: what the future might hold regarding novel biomarkers and add-on therapies.Oxid Med Cell Longevity 2019:7536805
DOI Google Scholar

Ganta S, Devalapally H, Shahiwala A, Amiji M, (2008) A review of stimuli-responsive nanocarriers for drug and gene delivery.J Control Release 126(3):187-204
DOI Google Scholar

Gaspar VM, Marques JG, Sousa F, Louro RO, Queiroz JA, Correia IJ, (2013) Biofunctionalized nanoparticles with pH-responsive and cell penetrating blocks for gene delivery.Nanotechnology 24(27):275101
DOI Google Scholar

Geborek P, Saxne T, Pettersson H, Wollheim F, (1989) Synovial fluid acidosis correlates with radiological joint destruction in rheumatoid arthritis knee joints.J Rheumatol 16(4):468-472
Google Scholar

Goldie I, Nachemson A, (1969) synovial pH in rheumatoid knee-joints. I. The effect of synovectomy.Acta Orthop Scand 40(5):634-641
DOI Google Scholar

Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J, (2018) Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies.Bone Res 6:15
DOI Google Scholar

Han D, Tong X, Zhao Y, (2012) Block copolymer micelles with a dual-stimuli-responsive core for fast or slow degradation.Langmuir 28(5):2327-2331
DOI Google Scholar

Heidarli E, Dadashzadeh S, Haeri A, (2017) State of the art of stimuli-responsive liposomes for cancer therapy.Iran J Pharm Res 16(4):1273-1304
Google Scholar

Huo M, Yuan J, Tao L, Wei Y, (2014) Redox-responsive polymers for drug delivery: from molecular design to applications.Polym Chem 5(5):1519-1528
DOI Google Scholar
Indermun S, Govender M, Kumar P, Choonara YE, Pillay V(2018) Stimuli-responsive polymers as smart drug delivery systems: classifications based on carrier type and triggered-release mechanism. In: Makhlouf ASH, Abu-Thabit NY (eds) Stimuli-responsive polymers as smart drug delivery systems: classifications based on carrier type and triggered-release mechanism. Elsevier, Amsterdam, pp 43-58
DOI

Jain M, Attur M, Furer V, Todd J, Ramirez R, Lock M, Lu QA, Abramson SB, Greenberg JD, (2015) Increased plasma IL-17F levels in rheumatoid arthritis patients are responsive to methotrexate, anti-TNF, and T cell costimulatory modulation.Inflammation 38(1):180-186
DOI Google Scholar

James HP, John R, Alex A, Anoop K, (2014) Smart polymers for the controlled delivery of drugs—a concise overview.Acta Pharm Sin B 4(2):120-127
DOI Google Scholar

Jin H, Zhu T, Huang X, Sun M, Li H, Zhu X, Liu M, Xie Y, Huang W, Yan D, (2019) ROS-responsive nanoparticles based on amphiphilic hyperbranched polyphosphoester for drug delivery: light-triggered size-reducing and enhanced tumor penetration.Biomaterials 211:68-80
DOI Google Scholar

Jung J, Lee IH, Lee E, Park J, Jon S, (2007) pH-sensitive polymer nanospheres for use as a potential drug delivery vehicle.Biomacromol 8(11):3401-3407
DOI Google Scholar

Karimi M, Eslami M, Sahandi-Zangabad P, Mirab F, Farajisafiloo N, Shafaei Z, Ghosh D, Bozorgomid M, Dashkhaneh F, Hamblin MR, (2016) pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents.Wiley Interdiscip Rev Nanomed Nanobiotechnol 8(5):696-716
DOI Google Scholar

Karimi M, Sahandi Zangabad P, Ghasemi A, Amiri M, Bahrami M, Malekzad H, Ghahramanzadeh Asl H, Mahdieh Z, Bozorgomid M, Ghasemi A, (2016) Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances.ACS Appl Mater Interfaces 8(33):21107-21133
DOI Google Scholar

Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G, (1991) Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.EMBO J 10(13):4025-4031
DOI Google Scholar

Khojah HM, Ahmed S, Abdel-Rahman MS, Hamza A-B, (2016) Reactive oxygen and nitrogen species in patients with rheumatoid arthritis as potential biomarkers for disease activity and the role of antioxidants.Free Radic Biol Med 97:285-291
DOI Google Scholar

Kim MS, Gruneich J, Jing H, Diamond SL, (2010) Photo-induced release of active plasmid from crosslinked nanoparticles: o-nitrobenzyl/methacrylate functionalized polyethyleneimine.J Mater Chem 20(17):3396-3403
DOI Google Scholar

Kim HJ, Lee S-M, Park K-H, Mun CH, Park Y-B, Yoo K-H, (2015) Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis.Biomaterials 61:95-102
DOI Google Scholar

Kuang T, Liu Y, Gong T, Peng X, Hu X, Yu Z, (2016) Enzyme-responsive nanoparticles for anticancer drug delivery.Curr Nanosci 12(1):38-46
DOI Google Scholar

Lee SM, Kim HJ, Ha YJ, Park YN, Lee SK, Park YB, Yoo KH, (2013) Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles.ACS Nano 7(1):50-57
DOI Google Scholar

Lima SAC, Reis S, (2015) Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: a multi-drug system for theranostic in rheumatoid arthritis.Colloids Surf B 133:378-387
DOI Google Scholar

Liu R, Li D, He B, Xu X, Sheng M, Lai Y, Wang G, Gu Z, (2011) Anti-tumor drug delivery of pH-sensitive poly (ethylene glycol)-poly (L-histidine-)-poly (L-lactide) nanoparticles.J Control Release 152(1):49-56
DOI Google Scholar

Liu J, Duong H, Whittaker MR, Davis TP, Boyer C, (2012) Synthesis of functional core, star polymers via RAFT polymerization for drug delivery applications.Macromol Rapid Commun 33(9):760-766
DOI Google Scholar

Liu L, Hu F, Wang H, Wu X, Eltahan AS, Stanford S, Bottini N, Xiao H, Bottini M, Guo W, (2019) Secreted protein acidic and rich in cysteine mediated biomimetic delivery of methotrexate by albumin-based nanomedicines for rheumatoid arthritis therapy.ACS Nano 13(5):5036-5048
DOI Google Scholar

Lopes JR, Santos G, Barata P, Oliveira R, Lopes CM, (2013) Physical and chemical stimuli-responsive drug delivery systems: targeted delivery and main routes of administration.Curr Pharm Des 19(41):7169-7184
DOI Google Scholar

Lu J, Choi E, Tamanoi F, Zink JI, (2008) Light-activated nanoimpeller-controlled drug release in cancer cells.Small 4(4):421-426
DOI Google Scholar

Lv C, Wang Z, Wang P, Tang X, (2012) Photodegradable polyurethane self-assembled nanoparticles for photocontrollable release.Langmuir 28(25):9387-9394
DOI Google Scholar

McInnes IB, O’Dell JR, (2010) State-of-the-art: rheumatoid arthritis.Ann Rheum Dis 69(11):1898-1906
DOI Google Scholar

McInnes IB, Schett G, (2017) Pathogenetic insights from the treatment of rheumatoid arthritis.Lancet 389(10086):2328-2337
DOI Google Scholar

Menkin V, (1956) Biology of inflammation.Science 123:527-534
DOI Google Scholar

Moon SJ, (2020) pH-Sensitive Polymeric Micelles as the Methotrexate Carrier for Targeting Rheumatoid Arthritis.Macromolecular Research 28:99-102
DOI Google Scholar

Mura S, Nicolas J, Couvreur P, (2013) Stimuli-responsive nanocarriers for drug delivery.Nat Mater 12(11):991-1003
DOI Google Scholar

Murthy N, Campbell J, Fausto N, Hoffman AS, Stayton PS, (2003) Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs.Bioconjug Chem 14(2):412-419
DOI Google Scholar

Nahire R, Paul S, Scott MD, Singh RK, Muhonen WW, Shabb J, Gange KN, Srivastava D, Sarkar K, Mallik S, (2012) Ultrasound enhanced matrix metalloproteinase-9 triggered release of contents from echogenic liposomes.Mol Pharm 9(9):2554-2564
DOI Google Scholar

Nogueira E, Gomes AC, Preto A, Cavaco-Paulo A, (2016) Folate-targeted nanoparticles for rheumatoid arthritis therapy.Nanomed Nanotechnol Biol Med 12(4):1113-1126
DOI Google Scholar

Oliveira IM, Gonçalves C, Reis RL, Oliveira JM, (2018) Engineering nanoparticles for targeting rheumatoid arthritis: past, present, and future trends.Nano Res 11(9):4489-4506
DOI Google Scholar

Patra JK, Das G, Fraceto LF, Campos EVR, del Pilar R-T, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, (2018) Nano based drug delivery systems: recent developments and future prospects.J Nanobiotechnol 16(1):71
DOI Google Scholar

Peper SM, Lew R, Mikuls T, Brophy M, Rybin D, Wu H, O'Dell J, (2017) Rheumatoid arthritis treatment after methotrexate: the durability of triple therapy versus etanercept.Arthritis Care Res 69(10):1467-1472
DOI Google Scholar

Pham CT, (2011) Nanotherapeutic approaches for the treatment of rheumatoid arthritis.Wiley Interdiscip Rev Nanomed Nanobiotechnol 3(6):607-619
DOI Google Scholar

Polyak B, Friedman G, (2009) Magnetic targeting for site-specific drug delivery: applications and clinical potential.Expert Opin Drug Deliv 6(1):53-70
DOI Google Scholar

Quan L-d, Thiele GM, Tian J, Wang D, (2008) The development of novel therapies for rheumatoid arthritis.Expert Opin Ther Pat 18(7):723-738
DOI Google Scholar

Rajamäki K, Nordström T, Nurmi K, Åkerman KE, Kovanen PT, Öörni K, Eklund KK, (2013) Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome.J Biol Chem 288(19):13410-13419
DOI Google Scholar

Raza A, Rasheed T, Nabeel F, Hayat U, Bilal M, Iqbal H, (2019) Endogenous and exogenous stimuli-responsive drug delivery systems for programmed site-specific release.Molecules 24(6):1117
DOI Google Scholar

Roiniotis J, Dinh H, Masendycz P, Turner A, Elsegood CL, Scholz GM, Hamilton JA, (2009) Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions.J Immunol 182(12):7974-7981
DOI Google Scholar

Sagnella SM, Duong H, MacMillan A, Boyer C, Whan R, McCarroll JA, Davis TP, Kavallaris M, (2014) Dextran-based doxorubicin nanocarriers with improved tumor penetration.Biomacromol 15(1):262-275
DOI Google Scholar

Sethuraman VA, Na K, Bae YH, (2006) pH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study.Biomacromol 7(1):64-70
DOI Google Scholar

Shen R, Mu B, Du P, Liu P, (2011) Preparation of photo-sensitive degradable polymeric nanocapsules from dendrimer grafted nano-silica templates.Soft Mater 9(4):382-392
DOI Google Scholar

Shenoy D, Little S, Langer R, Amiji M, (2005) Poly (ethylene oxide)-modified poly (β-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs 1 In vitro evaluations.Mol Pharm 2(5):357-366
DOI Google Scholar

Siafaka PI, Üstündağ Okur N, Karavas E, Bikiaris DN, (2016) Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: current status and uses.Int J Mol Sci 17(9):1440
DOI Google Scholar
SinghAAmijiMMStimuli-responsive drug delivery systems2018LondonRoyal Society of Chemistry

Singh P, Pandit S, Mokkapati V, Garg A, Ravikumar V, Mijakovic I, (2018) Gold nanoparticles in diagnostics and therapeutics for human cancer.Int J Mol Sci 19(7):100-100
DOI Google Scholar

Smolen JS, Aletaha D, Redlich K, (2012) The pathogenesis of rheumatoid arthritis: new insights from old clinical data?.Nat Rev Rheumatol 8(4):235
DOI Google Scholar

Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, Kavanaugh A, McInnes IB, Solomon DH, Strand V, Yamamoto K, (2018) Rheumatoid arthritis.Nat Rev Dis Primers 4(1):18001
DOI Google Scholar

Song N, Liu W, Tu Q, Liu R, Zhang Y, Wang J, (2011) Preparation and in vitro properties of redox-responsive polymeric nanoparticles for paclitaxel delivery.Colloids Surf B 87(2):454-463
DOI Google Scholar

Song R, Murphy M, Li C, Ting K, Soo C, Zheng Z, (2018) Current development of biodegradable polymeric materials for biomedical applications.Drug Des Dev Ther 12:3117
DOI Google Scholar

Sostres C, Gargallo CJ, Arroyo MT, Lanas A, (2010) Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract.Best Pract Res Clin Gastroenterol 24(2):121-132
DOI Google Scholar

Stuart MAC, Huck WT, Genzer J, Müller M, Ober C, Stamm M, Sukhorukov GB, Szleifer I, Tsukruk VV, Urban M, (2010) Emerging applications of stimuli-responsive polymer materials.Nat Mater 9(2):101-113
DOI Google Scholar

Ta T, Convertine AJ, Reyes CR, Stayton PS, Porter TM, (2010) Thermosensitive liposomes modified with poly (N-isopropylacrylamide-co-propylacrylic acid) copolymers for triggered release of doxorubicin.Biomacromol 11(8):1915-1920
DOI Google Scholar

Uslu A, Güvenaltın Ş, (2010) The investigation of structural and thermosensitive properties of new phosphazene derivatives bearing glycol and amino acid.Dalton Trans 39(44):10685-10691
DOI Google Scholar

van der Meel R, Sulheim E, Shi Y, Kiessling F, Mulder WJ, Lammers T, (2019) Smart cancer nanomedicine.Nat Nanotechnol 14(11):1007-1017
DOI Google Scholar

Vandewalle J, Luypaert A, De Bosscher K, Libert C, (2018) Therapeutic mechanisms of glucocorticoids.Trends Endocrinol Metab 29(1):42-54
DOI Google Scholar

Vats M, Mishra SK, Baghini MS, Chauhan DS, Srivastava R, De A, (2017) Near infrared fluorescence imaging in nano-therapeutics and photo-thermal evaluation.Int J Mol Sci 18(5):924
DOI Google Scholar

Wang S, Lv J, Meng S, Tang J, Nie L, (2020) Recent advances in nanotheranostics for treat-to-target of rheumatoid arthritis.Adv Healthc Mater 9(6):1901541
DOI Google Scholar

Wen J, Anderson SM, Du J, Yan M, Wang J, Shen M, Lu Y, Segura T, (2011) Controlled protein delivery based on enzyme-responsive nanocapsules.Adv Mater 23(39):4549-4553
DOI Google Scholar

Wilson DS, Dalmasso G, Wang L, Sitaraman SV, Merlin D, Murthy N, (2010) Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines.Nat Mater 9(11):923-928
DOI Google Scholar

Xu Y, Mu J, Xu Z, Zhong H, Chen Z, Ni Q, Liang X-J, Guo S, (2020) Modular acid-activatable acetone-based ketal-linked nanomedicine by dexamethasone prodrugs for enhanced anti-rheumatoid arthritis with low side effects.Nano Lett 20(4):2558-2568
DOI Google Scholar

Yang B, Jia H, Wang X, Chen S, Zhang X, Zhuo R, Feng J, (2014) Self-assembled vehicle construction via boronic acid coupling and host-guest interaction for serum-tolerant DNA transport and pH-responsive drug delivery.Adv Healthc Mater 3(4):596-608
DOI Google Scholar

Yoon S, Kim WJ, Yoo HS, (2013) Dual-responsive breakdown of nanostructures with high doxorubicin payload for apoptotic anticancer therapy.Small 9(2):284-293
DOI Google Scholar

Yu C, Li X, Hou Y, Meng X, Wang D, Liu J, Sun F, Li Y, (2019) Hyaluronic acid coated acid-sensitive nanoparticles for targeted therapy of adjuvant-induced arthritis in rats.Molecules 24(1):146
DOI Google Scholar

Zhang G, Jiang X, (2019) Temperature responsive nanoparticles based on PEGylated polyaspartamide derivatives for drug delivery.Polymers 11(2):316
DOI Google Scholar

Zhang T, Sturgis TF, Youan B-BC, (2011) pH-responsive nanoparticles releasing tenofovir intended for the prevention of HIV transmission.Eur J Pharm Biopharm 79(3):526-536
DOI Google Scholar

Zhang S, Wu L, Cao J, Wang K, Ge Y, Ma W, Qi X, Shen S, (2018) Effect of magnetic nanoparticles size on rheumatoid arthritis targeting and photothermal therapy.Colloids Surf B 170:224-232
DOI Google Scholar

Zhao J, (2017) Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis.Int J Nanomed 12:6735
DOI Google Scholar

Zhao M, Biswas A, Hu B, Joo KI, Wang P, Gu Z, Tang Y, (2011) Redox-responsive nanocapsules for intracellular protein delivery.Biomaterials 32(22):5223-5230
DOI Google Scholar

Zhao J, Zhang X, Sun X, Zhao M, Yu C, Lee RJ, Sun F, Zhou Y, Li Y, Teng L, (2018) Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis.Eur J Pharm Biopharm 130:39-47
DOI Google Scholar

Zubris KA, Liu R, Colby A, Schulz MD, Colson YL, Grinstaff MW, (2013) In vitro activity of paclitaxel-loaded polymeric expansile nanoparticles in breast cancer cells.Biomacromol 14(6):2074-2082
DOI Google Scholar
Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Received: 01 June 2020
Accepted: 15 July 2020
Published: 06 October 2020
Issue date: October 2020

Copyright

© The Author(s) 2020

Acknowledgements

Acknowledgements

The authors thank the financial support under the National Natural Science Foundation of China (31971302 and 51903062), Natural Science Foundation of Guangdong Province of China (2019A1515011597 and 2018A030313588) and Project of Educational Commission of Guangdong Province of China (2017KQNCX163).

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Return