Cartilage-bone inspired the construction of soft-hard composite material with excellent interfacial binding performance and low friction for artificial joints

Qin CHEN; Xinyue ZHANG; Siyu LIU; Kai CHEN; Cunao FENG; Xiaowei LI; Jianwei QI; Yong LUO; Hongtao LIU; Dekun ZHANG

doi:10.1007/s40544-022-0645-2

Friction 2023, 11(7): 1177-1193 https://doi.org/10.1007/s40544-022-0645-2

Research Article |

Open Access | Issue | Published: 16 July 2022

Cartilage-bone inspired the construction of soft-hard composite material with excellent interfacial binding performance and low friction for artificial joints

Show Author's Information Hide Author's Information Qin CHEN^{¹^,³^,^†}, Xinyue ZHANG^{²^,^†}, Siyu LIU^¹, Kai CHEN^{¹^,⁴^,⁵}(

), Cunao FENG^¹, Xiaowei LI^¹, Jianwei QI^¹, Yong LUO^¹, Hongtao LIU^¹, Dekun ZHANG^¹(

)

1 School of Materials Science and Physics, China University of Mining and Technology, Xuzhou 221116, China

2 School of Mechatronic Engineering, China University of Mining and Technology, Xuzhou 221116, China

3 School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, China

4 State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China

5 State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China

† Qin CHEN and Xinyue ZHANG contributed equally to this work.

Keywords:

friction, hydrogel, Ti6Al4V alloy, soft-hard interface

Cite this article:

CHEN Q, ZHANG X, LIU S, et al. Cartilage-bone inspired the construction of soft-hard composite material with excellent interfacial binding performance and low friction for artificial joints. Friction, 2023, 11(7): 1177-1193. https://doi.org/10.1007/s40544-022-0645-2

Download citation

EndNote(RIS)

BibTeX

577

Views

Downloads

Citations

Crossref

WoS

Scopus

CSCD

Abstract Full text About this article

Abstract

Inspired by the cartilage-bone structure in natural joints, soft-hard integrated materials have received extensive attention, which are the most promising candidates for artificial joints due to their combination of excellent load-bearing properties and lubricating properties. The latest progress showed that the combination of hydrogel and titanium alloy can realize a bionic natural joint lubrication system on the surface of titanium alloy. However, obtaining a tough interface between the hydrogel (soft and wet) and the titanium substrate (hard and dry) is still a great challenge. Here, we designed a "soft (hydrogel)-hard (Ti6Al4V)" integrated material with outstanding combination, which simulates the structure and function of cartilage-bone in the natural joint. The load-bearing properties, binding performance, and tribological behaviors for different forms of the soft-hard integrated materials were investigated. The results showed that the hydrogel layer and Ti6Al4V substrate possess ultra-high interfacial toughness (3,900 J/m²). In addition, the combination of the hydrogel layer and Ti6Al4V substrate provided a good lubrication system to endow the "soft (hydrogel)-hard (Ti6Al4V)" integrated material with high load-bearing and excellent tribological properties. Therefore, this study provided an effective strategy for prolonging the service life of Ti6Al4V in the biomedical field.

Full text

Abstract

Full text

Outline

About this article

Cartilage-bone inspired the construction of soft-hard composite material with excellent interfacial binding performance and low friction for artificial joints

Show Author's information Hide Author's Information Qin CHEN^{¹^,³^,^†}, Xinyue ZHANG^{²^,^†}, Siyu LIU^¹, Kai CHEN^{¹^,⁴^,⁵}(

), Cunao FENG^¹, Xiaowei LI^¹, Jianwei QI^¹, Yong LUO^¹, Hongtao LIU^¹, Dekun ZHANG^¹(

)

1 School of Materials Science and Physics, China University of Mining and Technology, Xuzhou 221116, China

2 School of Mechatronic Engineering, China University of Mining and Technology, Xuzhou 221116, China

3 School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, China

4 State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China

5 State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China

† Qin CHEN and Xinyue ZHANG contributed equally to this work.

Abstract

Keywords: friction, hydrogel, Ti6Al4V alloy, soft-hard interface

References(52)

[1]

Forster H, Fisher J. The influence of loading time and lubricant on the friction of articular cartilage. Proc Inst Mech En Part H-J Eng Med 210(2): 109–119 (1996)

DOI Google Scholar

[2]

Macirowski T, Tepic S, Mann R W. Cartilage stresses in the human hip joint. J Biomech Eng 116(1): 10–18 (1994)

DOI Google Scholar

[3]

Devitt B M, Bell S W, Webster K E, Feller J A, Whitehead T S. Surgical treatments of cartilage defects of the knee: Systematic review of randomised controlled trials. Knee 24(3): 508–517 (2017)

DOI Google Scholar

[4]

Chuah Y J, Peck Y, Lau J E J, Heec H T, Wang D A. Hydrogel based cartilaginous tissue regeneration: recent insights and technologies. Biomater Sci 5(4): 613–631 (2017)

DOI Google Scholar

[5]

Rahaman M N, Yao A H, Bal B S, Garino J P, Ries M D. Ceramics for prosthetic hip and knee joint replacement. J Am Ceram Soc 90(7): 1965–1988 (2007)

DOI Google Scholar

[6]

Ingham E, Fisher J. Biological reactions to wear debris in total joint replacement. Proc Inst Mech En Part H-J Eng Med 214(H1): 21–37 (2000)

DOI Google Scholar

[7]

Chen K, Liu J L, Yang X H, Zhang D K. Preparation, optimization and property of PVA-HA/PAA composite hydrogel. Mater Sci Eng C-Mater Biol Appl 78: 520–529 (2017)

DOI Google Scholar

[8]

Long M, Rack H J. Titanium alloys in total joint replacement—A materials science perspective. Biomaterials 19(18): 1621–1639 (1998)

DOI Google Scholar

[9]

Standert V, Borcherding K, Bormann N, Schmidmaier G, Grunwald I, Wildemann B. Antibiotic-loaded amphora-shaped pores on a titanium implant surface enhance osteointegration and prevent infections. Bioact Mater 6(8): 2331–2345 (2021)

DOI Google Scholar

[10]

Palmquist A, Snis A, Emanuelsson L, Browne M, Thomsen P. Long-term biocompatibility and osseointegration of electron beam melted, free-form-fabricated solid and porous titanium alloy: Experimental studies in sheep. J Biomater Appl 27(8): 1003–1016 (2013)

DOI Google Scholar

[11]

Jinno T, Goldberg V M, Davy D, Stevenson S. Osseointegration of surface-blasted implants made of titanium alloy and cobalt-chromium alloy in a rabbit intramedullary model. J Biomed Mater Res 42(1): 20–29 (1998)

DOI

[12]

Park J W, Park K B, Suh J Y. Effects of calcium ion incorporation on bone healing of Ti6Al4V alloy implants in rabbit tibiae. Biomaterials 28(22): 3306–3313 (2007)

DOI Google Scholar

[13]

Sott A H, Rosson J W. The influence of biomaterial on patterns of failure after cemented total hip replacement. Int Orthop 26(5): 287–290 (2002)

DOI Google Scholar

[14]

Zhang C, Liu Z, Liu Y, Ren J, Cheng Q, Yang C, Cai L. Novel tribological stability of the superlubricity poly (vinylphosphonic acid) (PVPA) coatings on Ti6Al4V: Velocity and load independence. Appl Surf Sci 392: 19–26 (2017)

DOI Google Scholar

[15]

Wang K, Xiong D. Construction of lubricant composite coating on Ti6Al4V alloy using micro-arc oxidation and grafting hydrophilic polymer. Mater Sci Eng C-Mater Biol Appl 90: 219–226 (2018)

DOI Google Scholar

[16]

Zhao Z T, Gao W W, Bai H. A mineral layer as an effective binder to achieve strong bonding between a hydrogel and a solid titanium substrate. J Mat Chem B 6(23): 3859–3864 (2018)

DOI Google Scholar

[17]

Chen K, Chen G Y, Wei S, Yang X H, Zhang D K, Xu L M. Preparation and property of high strength and low friction PVA-HA/PAA composite hydrogel using annealing treatment. Mater Sci Eng C-Mater Biol Appl 91: 579–588 (2018)

DOI Google Scholar

[18]

Yang F C, Zhao J C, Koshut W J, Watt J, Riboh J C, Gall K, Wiley B J. A Synthetic hydrogel composite with the mechanical behavior and durability of cartilage. Adv Funct Mater 30(36): 202003451 (2020)

DOI Google Scholar

[19]

Cui L L, Chen J Y, Yan C Q, Xiong D S. Articular Cartilage Inspired the Construction of LTi-DA-PVA Composite Structure with Excellent Surface Wettability and Low Friction Performance. Tribol Lett 69(2): 41 (2021)

DOI Google Scholar

[20]

Zhou H J, Xiong D S, Tong W, Shi Z B, Xiong X Y. Lubrication behaviors of PVA-casted LSPEEK hydrogels in artificial cartilage repair. J Appl Polym Sci 136(37): 47944 (2019)

DOI Google Scholar

[21]

Baker M I, Walsh S P, Schwartz Z, Boyan B D. A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. J Biomed Mater Res Part B 100B(5): 1451–1457 (2012)

DOI Google Scholar

[22]

Zhang Y S, Khademhosseini A. Advances in engineering hydrogels. Science 356(6337): eaaf3627 (2017)

DOI Google Scholar

[23]

Gu Z P, Huang K Q, Luo Y, Zhang L B, Kuang T R, Chen Z, Liao G C. Double network hydrogel for tissue engineering. Wiley Interdiscip Rev-Nanomed Nanobiotechnol 10(6): e1520 (2018)

DOI Google Scholar

[24]

Zhao Z G, Fang R C, Rong Q F, Liu M J. Bioinspired nanocomposite hydrogels with highly ordered structures. Adv Mater 29(45): 1703045 (2017)

DOI Google Scholar

[25]

Vaz C M, Reis R L, Cunha A M. Use of coupling agents to enhance the interfacial interactions in starch-EVOH/hydroxylapatite composites. Biomaterials 23(2): 629–635 (2002)

DOI Google Scholar

[26]

Arts J J C, Verdonschot N, Schreurs B W, Buma P. The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting. Biomaterials 27(7): 1110–1118 (2006)

DOI Google Scholar

[27]

Zhang D K, Duan J J, Wang D G, Ge S R. Effect of preparation methods on mechanical properties of PVA/HA composite hydrogel. J Bionic Eng 7(3): 235–243 (2010)

DOI Google Scholar

[28]

Li W X, Wang D, Yang W, Song Y. Compressive mechanical properties and microstructure of PVA-HA hydrogels for cartilage repair. RSC Adv 6(24): 20166–20172 (2016)

DOI Google Scholar

[29]

Cheng Y Z, Hu Y C, Xu M J, Qin M, Lan W W, Huang D, Wei Y, Chen W Y. High strength polyvinyl alcohol/polyacrylic acid (PVA/PAA) hydrogel fabricated by Cold-Drawn method for cartilage tissue substitutes. J Biomater Sci - Polym Ed 31(14): 1836–1851 (2020)

DOI Google Scholar

[30]

Faturechi R, Karimi A, Hashemi A, Yousefi H, Navidbakhsh M. Influence of poly(acrylic acid) on the mechanical properties of composite hydrogels. Adv Polym Technol 34(2): 21487 (2015)

DOI Google Scholar

[31]

Gulyuz U, Okay O. Self-healing poly(acrylic acid) hydrogels with shape memory behavior of high mechanical strength. Macromolecules 47(19): 6889–6899 (2014)

DOI Google Scholar

[32]

Chen K, Zhang D K, Cui X T, Wang Q L. Preparation of ultrahigh-molecular-weight polyethylene grafted with polyvinyl alcohol hydrogel as an artificial joint. RSC Adv 5(31): 24215–24223 (2015)

DOI Google Scholar

[33]

Zhao Z T, Gao W W, Bai H. A mineral layer as an effective binder to achieve strong bonding between a hydrogel and a solid titanium substrate. J Mat Chem B 6(23): 3859–3864 (2018)

DOI Google Scholar

[34]

Cheng H, Yue K, Kazemzadeh-Narbat M, Liu Y H, Khalilpour A, Li B Y, Zhang Y S, Annabi N, Khademhosseini A. Mussel-inspired multifunctional hydrogel coating for prevention of infections and enhanced osteogenesis. ACS Appl Mater Interface 9(13): 11428–11439 (2017)

DOI Google Scholar

[35]

Kurokawa T, Furukawa H, Wang W, Tanaka Y, Gong J P. Formation of a strong hydrogel-porous solid interface via the double-network principle. Acta Biomater 6(4): 1353–1359 (2010)

DOI Google Scholar

[36]

Yuk H, Zhang T, Lin S T, Parada G A, Zhao X H. Tough bonding of hydrogels to diverse non-porous surfaces. Nat Mater 15(2): 190–196 (2016)

DOI Google Scholar

[37]

Han L, Lu X, Liu K Z, Wang K F, Fang L M, Weng L T, Zhang H P, Tang Y H, Ren F Z, Zhao C C, Sun G X, Liang R, Li Z J. Mussel-inspired adhesive and tough hydrogel based on nanoclay confined dopamine polymerization. ACS Nano 11(3): 2561–2574 (2017)

DOI Google Scholar

[38]

Jing X, Mi H Y, Lin Y J, Enriquez E, Peng X F, Turng L S. Highly stretchable and biocompatible strain sensors based on mussel-inspired super-adhesive self-healing hydrogels for human motion monitoring. Acs Appl Mater Interfaces 10(24): 20897–20909 (2018)

DOI Google Scholar

[39]

Su T, Zhang M Y, Zeng Q K, Pan W H, Huang Y J, Qian Y N, Dong W, Qi X L, Shen J L. Mussel-inspired agarose hydrogel scaffolds for skin tissue engineering. Bioact Mater 6(3): 579–588 (2021)

DOI Google Scholar

[40]

Tang Z W, Miao Y N, Zhao J, Xiao H, Zhang M, Liu K, Zhang X Y, Huang L L, Chen L H, Wu H. Mussel-inspired biocompatible polydopamine/carboxymethyl cellulose/polyacrylic acid adhesive hydrogels with UV-shielding capacity. Cellulose 28(3): 1527–1540 (2021)

DOI Google Scholar

[41]

Chen K, Liu S Y, Wu X F, Wang F Y, Chen G Y, Yang X H, Xu L M, Qi J W, Luo Y, Zhang D K. Mussel-inspired construction of Ti6Al4V-hydrogel artificial cartilage material with high strength and low friction. Mater Lett 265: 127421 (2020)

DOI Google Scholar

[42]

Biggins J S, Saintyves B, Wei Z Y, Bouchaud E, Mahadevan L. Digital instability of a confined elastic meniscus. Proc Natl Acad Sci U S A 110(31): 12545–12548 (2013)

DOI Google Scholar

[43]

Bobyn J D, Wilson G J, MacGregor D C, Pilliar R M, Weatherly G C. Effect of pore size on the peel strength of attachment of fibrous tissue to porous-surfaced implants. J Biomed Mater Res 16(5): 571–584 (1982)

DOI Google Scholar

[44]

Moretti M, Wendt D, Schaefer D, Jakob M, Hunziker E B, Heberer M, Martin I. Structural characterization and reliable biomechanical assessment of integrative cartilage repair. J Biomech 38(9): 1846–1854 (2005)

DOI Google Scholar

[45]

Yuk H, Zhang T, Parada G A, Liu X Y, Zhao X H. Skin-inspired hydrogel-elastomer hybrids with robust interfaces and functional microstructures. Nat Commun 7: 12028 (2016)

DOI Google Scholar

[46]

Zhang Y X, Ren B P, Xie S W, Cai Y Q, Wang T, Feng Z Q, Tang J X, Chen Q, Xu J X, Xu L J, Zheng J. Multiple physical cross-linker strategy to achieve mechanically tough and reversible properties of double-network hydrogels in bulk and on surfaces. Acs Appl Polym Mater 1(4): 701–713 (2019)

DOI Google Scholar

[47]

Xu J Y, Gao G H, Duan L J, Sun G X. Protein and hydrophobic association-regulated hydrogels with adhesive adjustability in different materials. Adv Mater Interfaces 7(1): 1901541 (2020)

DOI Google Scholar

[48]

Zhang Y K, Xue J J, Li D P, Li H Y, Huang Z H, Huang Y W, Gong C J, Long S J, Li X F. Tough hydrogels with tunable soft and wet interfacial adhesion. Polym Test 93: 106976 (2021)

DOI Google Scholar

[49]

Gong J P. Friction and lubrication of hydrogels - its richness and complexity. Soft Matter 2(7): 544–552 (2006)

DOI Google Scholar

[50]

Chen K, Zhang D K, Yang X H, Cui X T, Zhang X, Wang Q L. Research on torsional friction behavior and fluid load support of PVA/HA composite hydrogel. J Mech Behav Biomed Mater 62: 182–194 (2016)

DOI Google Scholar

[51]

Cai Z B, Gao S S, Gan X Q, Yu H Y, Zhu M H. Torsional fretting wear behaviour of nature articular cartilage in vitro. Int J Surf Sci Eng 5(5–6): 348–368 (2011)

DOI Google Scholar

[52]

Gan X Q, Cai Z B, Qiao M T, Gao S S, Zhu M H, Yu H Y. Fretting wear behaviors of mandibular condylar cartilage of nature temporomandibular joint in vitro. Tribol Int 63: 204–212 (2013)

DOI Google Scholar

About this article

Publication history

Acknowledgements

Rights and permissions

Publication history

Received: 22 October 2021

Revised: 25 January 2022

Accepted: 04 May 2022

Published: 16 July 2022

Issue date: July 2023

Copyright

Acknowledgements

This work was financially supported by Natural Science Foundation of Jiangsu Province (Grant No. BK20211243), National Natural Science Foundation of China (Grant Nos. 51705517, 51875563, 51875564), the Tribology Science Fund of State Key Laboratory of Tribology (Grant No. SKLTKF21B15) and the Open Fund of State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics (Grant No. LSL-2107).

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.