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Research Article

A highly accessible copper single-atom catalyst for wound antibacterial application

Yue Zhao1,§Yunpeng Yu1,§Feng Gao1Zhiyuan Wang1Wenxing Chen3Cai Chen4Jia Yang1Yancai Yao1Junyi Du1Chao Zhao1Yuen Wu1,2( )
Department of Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) University of Science and Technology of ChinaHefei 230026 China
Dalian National Laboratory for Clean EnergyDalian 116023 China
Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science and Engineering, Beijing Institute of TechnologyBeijing 100081 China
College of Chemistry and Chemical Engineering Southwest Petroleum UniversityChengdu 610500 China

§ Yue Zhao and Yunpeng Yu contributed equally to this work.

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Graphical Abstract


Bacterial infection arised from multipathogenic bacteria is a tricky issue that attracts worldwide attentions. In this paper, a highly accessible copper single-atom catalyst (Cu SAC) supported by biocompatible N-doped mesoporous carbon nanospheres was synthesized with the emulsion-template method. The tightly anchored copper single-atom of the catalyst could effectively transform O2 into O2• under ambient conditions by the ultra-large pore size (~ 23.80 nm) and small particle size (~ 97.71 nm). Due to multiple synergistically oxidative damages to biomolecules, the Cu SAC could be employed to eliminate different bacteria in vitro without the generation of multidrug resistance (MDR). Moreover, the Cu SAC could also promote wound healing in vivo by eradicating the propagation of bacteria at wound. It is envisioned that the Cu SAC with superior antibacterial performance could be applied in the treatment of related bacterial infection in future.

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12274_2021_3432_MOESM1_ESM.pdf (3.3 MB)
Nano Research
Pages 4808-4813
Cite this article:
Zhao Y, Yu Y, Gao F, et al. A highly accessible copper single-atom catalyst for wound antibacterial application. Nano Research, 2021, 14(12): 4808-4813.






Web of Science






Received: 02 February 2021
Revised: 26 February 2021
Accepted: 01 March 2021
Published: 10 April 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021