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The photothermal therapy (PTT) technique is regarded as a promising method for cancer treatment. However, one of the obstacles preventing its clinical application is the non-degradability and biotoxicity of the existing heavy-metal and carbon-based therapeutic agents. Therefore, a PTT material with a high photothermal efficiency, low toxicity, and good biocompatibility is urgently wanted. Herein, we report a titanium oxide-based therapeutic agent with a high efficacy and low toxicity for the PTT process. We demonstrated that Magnéli-phase Ti8O15 nanoparticles fabricated by the arc-melting method exhibit > 98% absorption of near infrared light and a superior photothermal therapy effect in the in vivo mouse model. The Ti8O15 nanoparticle PTT material also shows a good biocompatibility and biosafety. Our study reveals Magnéli-phase titanium oxide as a new family of PTT agents and introduces new applications of titanium oxides for photothermal conversion.

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Publication history

Received: 13 October 2015
Revised: 06 January 2016
Accepted: 12 January 2016
Published: 29 September 2016
Issue date: May 2016

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© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 51302180, 51222203, 51002100, and 51132006), the National Basic Research Program of China (Nos. 2011CB911002 and 2012CB932601), and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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Reprints and Permission requests may be sought directly from editorial office.
Email: nanores@tup.tsinghua.edu.cn

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