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Rattle structure is a topic of great interest in design and application of nanomaterials due to the unique core@void@shell architecture and the integration of functions. Herein, we developed a novel "ship-in-a-bottle" method to fabricate upconverting (UC) luminescent nanorattles by incorporating lanthanide-doped fluorides into hollow mesoporous silica. The size of nanorattles and the filling amount of fluorides can be well controlled. In addition, the modification of silica shell (with phenylene and amine groups) and the variation of efficient UC fluorides (NaYF4: Yb, Er, NaLuF4: Yb, Er, NaGdF4: Yb, Er and LiYF4: Yb, Er) were readily achieved. The resulting nanorattles exhibited a high capacity and pH-dependent release of the anti-cancer drug doxorubicin (DOX). Furthermore, we employed these nanorattles in proof-of-concept UC-monitoring drug release by utilizing the energy transfer process from UC fluorides to DOX, thus revealing the great potential of the nanorattles as efficient cancer theranostic agent.
This work is supported by the National Basic Research Program of China (No. 2014CB845605), Special Project of National Major Scientific Equipment Development of China (No. 2012YQ120060), the National Natural Science Foundation of China (Nos. 21201163, 21401196, U1305244, and 21325104), the CAS/SAFEA International Partnership Program for Creative Research Teams, and Strategic Priority Research Program of the CAS (No. XDA09030307).