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In this study, we present the preparation of stable 1T-WS2 ultrathin nanosheets with N4+ intercalation using a bottom-up hydrothermal method and the potential application of this material in light-induced photothermal cancer therapy. Our results revealed that nanosheets with a size of 150 nm were highly hydrophilic and exhibited strong light absorption and excellent photostability in the broad near-infrared wavelength region. The in vitro experimental results indicated good biocompatibility of the nanosheets. More notably, our in vivo antitumor experiments illustrated that light-induced photothermal ablation originating from irradiation of the 1T-WS2 nanosheets with an 808 nm laser could efficiently kill tumor cells; these effects were obtained not only at the cellular level but also in the living organs of mice. This result may lead to new applications of two-dimensional layered materials in novel photothermal therapies and other photothermal related fields.

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Publication history
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Acknowledgements

Publication history

Received: 08 July 2015
Revised: 07 September 2015
Accepted: 19 September 2015
Published: 28 October 2015
Issue date: December 2015

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015

Acknowledgements

Acknowledgements

We acknowledge the financial support of the National Basic Research Program of China (Nos. 2012CB825800, 2014CB848900, and 2014CB932500), the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (No. 11321503), the National Natural Science Foundation of China (Nos. U1232131, U1532112, 11321503, 51222202, 91123010, and 11574280) and the Fundamental Research Funds for the Central Universities (No. WK2310000035). L. S. thanks the recruitment program of global experts, the CAS Hundred Talent Program. The authors would like to acknowledge Prof. Chuanhong Jin from the Center of Electron Microscopy of Zhejiang University for the assistance on HAADF-STEM.

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