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Cancer Innovation 2022, 1(1): 92-113 https://doi.org/10.1002/cai2.7
Review | Open Access | Issue | Published: 11 June 2022

Crosstalk between ferroptosis and stress—Implications in cancer therapeutic responses

Show Author's Information Cheng Zhang1,  Jiao‐jiao Yu1,  Chen Yang1,  Shuang Shang1,  Xiao‐xi Lv1,  Bing Cui1( ),  Fang Hua1 ( )
CAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Keywords:
stress, ferroptosis, tumor therapeutic response, crosstalk
Cite this article:
Zhang C, Yu J, Yang C, et al. Crosstalk between ferroptosis and stress—Implications in cancer therapeutic responses. Cancer Innovation, 2022, 1(1): 92-113. https://doi.org/10.1002/cai2.7
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Abstract Full text About this article

Ferroptosis is a newly discovered form of cell death that is characterized by the accumulation of iron‐dependent lipid peroxidation. Research on ferroptosis has seen exponential growth over the past few years. Tumor cells are strongly dependent on iron for their growth, which makes them develop mechanisms to increase iron uptake and inhibit iron output, thereby completing iron accumulation. Ferroptosis can be induced or inhibited by various stresses through multiple mechanisms, making it stands at the crossroads of stresses related cancer cell fate determination. In this review, we give a brief summary of ferroptosis hallmarks and provide a systematic analysis of the current molecular mechanisms and regulatory networks of diverse stress conditions on ferroptosis. We also discuss the relationships between ferroptosis and cancer therapy responses to further understand potential targets and therapeutic strategies for cancer treatment.


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About this article

Crosstalk between ferroptosis and stress—Implications in cancer therapeutic responses

Show Author's information Cheng Zhang1, Jiao‐jiao Yu1, Chen Yang1, Shuang Shang1, Xiao‐xi Lv1, Bing Cui1( ), Fang Hua1 ( )
CAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Abstract

Ferroptosis is a newly discovered form of cell death that is characterized by the accumulation of iron‐dependent lipid peroxidation. Research on ferroptosis has seen exponential growth over the past few years. Tumor cells are strongly dependent on iron for their growth, which makes them develop mechanisms to increase iron uptake and inhibit iron output, thereby completing iron accumulation. Ferroptosis can be induced or inhibited by various stresses through multiple mechanisms, making it stands at the crossroads of stresses related cancer cell fate determination. In this review, we give a brief summary of ferroptosis hallmarks and provide a systematic analysis of the current molecular mechanisms and regulatory networks of diverse stress conditions on ferroptosis. We also discuss the relationships between ferroptosis and cancer therapy responses to further understand potential targets and therapeutic strategies for cancer treatment.

Keywords: stress, ferroptosis, tumor therapeutic response, crosstalk

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Publication history
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Acknowledgements
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Publication history

Received: 22 February 2022
Accepted: 15 April 2022
Published: 11 June 2022
Issue date: June 2022

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© 2022 The Authors.

Acknowledgements

This study was supported by grants from the National Key R&D Program of China (2017YFA0205400), the National Natural Science Foundation of China (81973344 to FH; 81874316 to BC and 82173379 to JJY), CAMS Innovation Fund for Medical Sciences (2021‐I2M‐1‐021 to FH and SS), Peking Union Medical College Graduate Innovation Fund (2019‐1007‐24 to CZ), Central Public‐interest Scientific Institution Basal Research Fund (2018PT35004), and Beijing Outstanding Young Scientist Program (BJJWZYJH01201910023028). The authors sincerely apologize for not being able to keep as many important primary papers in the References because of strict space constraints.

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