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Lung cancer is the malignant tumor with the highest morbidity and mortality in China, and nonsmall cell lung cancer is a common form of lung cancer. After undergoing chemotherapy and molecular targeted therapy, the treatment of lung cancer has now fully entered the era of immunotherapy. Immunotherapy‐based treatment has become one of the standard treatments for lung cancer. Immunotherapy has also gradually moved from the back line to the front line, from advanced to early patients. This article focuses on the latest developments in perioperative and advanced lung cancer immunotherapy, discusses the problems and challenges at the current stage, and explores new directions for future development.


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Recent advances in immunotherapy for lung cancer

Show Author's information Qi WangChunxia SuCaicun Zhou( )
Department of Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China

Qi Wang and Chunxia Su contributed equally to this study and shared the first authorship.

Abstract

Lung cancer is the malignant tumor with the highest morbidity and mortality in China, and nonsmall cell lung cancer is a common form of lung cancer. After undergoing chemotherapy and molecular targeted therapy, the treatment of lung cancer has now fully entered the era of immunotherapy. Immunotherapy‐based treatment has become one of the standard treatments for lung cancer. Immunotherapy has also gradually moved from the back line to the front line, from advanced to early patients. This article focuses on the latest developments in perioperative and advanced lung cancer immunotherapy, discusses the problems and challenges at the current stage, and explores new directions for future development.

Keywords: nonsmall cell lung cancer, small cell lung cancer, perioperative period, late stage, new immunotherapy

References(28)

1

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J Clin. 2021;71(1): 7–33. https://doi.org/10.3322/caac.21654

2

Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non‐small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83(5): 584–94. https://doi.org/10.4065/83.5.584

3

Yang CY, Yang JCH, Yang PC. Precision management of advanced non‐small cell lung cancer. Annu Rev Med. 2020;71: 117–36. https://doi.org/10.1146/annurev-med-051718-013524

4

Felip E, Altorki N, Zhou C, Csőszi T, Vynnychenko I, Goloborodko O, et al. Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB‐IIIA non‐small‐cell lung cancer (IMpower010): a randomised, multicentre, open‐label, phase 3 trial. Lancet. 2021;398(10308): 1344–57. https://doi.org/10.1016/S0140-6736(21)02098-5

5

O'Brien M, Paz‐Ares L, Marreaud S, Dafni U, Oselin K, Havel L, et al. Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB‐IIIA non‐small‐cell lung cancer (PEARLS/KEYNOTE‐091): an interim analysis of a randomised, triple‐blind, phase 3 trial. Lancet Oncol. 2022;23(10): 1274–86. https://doi.org/10.1016/S1470-2045(22)00518-6

6

Provencio M, Serna‐Blasco R, Nadal E, Insa A, García‐Campelo MR, Casal Rubio J, et al. Overall survival and biomarker analysis of neoadjuvant nivolumab plus chemotherapy in operable stage IIIA non‐small‐cell lung cancer (NADIM phase II trial). J Clin Oncol. 2022;40(25): 2924–33. https://doi.org/10.1200/JCO.21.02660

7

Raboso‐Moreno B, de la Viña JI, Gato‐Díaz P, Jiménez‐Fernández M, Olaiz‐Navarro B. NADIM II study: what is the ideal time for surgery in Stage IIIA lung cancer. Arch Bronconeumol. 2022;S0300‐2896(22): 00574–9. https://doi.org/10.1016/j.arbres.2022.08.014

8

Borghaei H, Gettinger S, Vokes EE, Chow LQM, Burgio MA, de Castro Carpeno J, et al. Five‐Year outcomes from the randomized, phase III trials CheckMate 017 and 057: nivolumab versus docetaxel in previously treated non‐small‐cell lung cancer. J Clin Oncol. 2021;39(7): 723–33. https://doi.org/10.1200/JCO.20.01605

9

Vokes EE, Ready N, Felip E, Horn L, Burgio MA, Antonia SJ, et al. Nivolumab versus docetaxel in previously treated advanced non‐small‐cell lung cancer (CheckMate 017 and CheckMate 057): 3‐year update and outcomes in patients with liver metastases. Ann Oncol. 2018;29(4): 959–65. https://doi.org/10.1093/annonc/mdy041

10

Reck M, Rodríguez–Abreu D, Robinson AG, Hui R, Csőszi T, Fülöp A, et al. Updated analysis of KEYNOTE‐024: pembrolizumab versus Platinum‐Based chemotherapy for advanced non‐small‐cell lung cancer with PD‐L1 tumor proportion score of 50% or greater. J Clin Oncol. 2019;37(7): 537–46. https://doi.org/10.1200/JCO.18.00149

11

Zhou C, Chen G, Huang Y, Zhou J, Lin L, Feng J, et al. Camrelizumab plus carboplatin and pemetrexed versus chemotherapy alone in chemotherapy‐naive patients with advanced non‐squamous non‐small‐cell lung cancer (CameL): a randomised, open‐label, multicentre, phase 3 trial. Lancet Respir Med. 2021;9(3): 305–14. https://doi.org/10.1016/S2213-2600(20)30365-9

12

Ren S, Chen J, Xu X, Jiang T, Cheng Y, Chen G, et al. Camrelizumab plus carboplatin and paclitaxel as first‐Line treatment for advanced squamous NSCLC (CameL‐Sq): a phase 3 trial. J Thorac Oncol. 2022;17(4): 544–57. https://doi.org/10.1016/j.jtho.2021.11.018

13

Rodríguez‐Abreu D, Powell SF, Hochmair MJ, Gadgeel S, Esteban E, Felip E, et al. Pemetrexed plus platinum with or without pembrolizumab in patients with previously untreated metastatic nonsquamous NSCLC: protocol‐specified final analysis from KEYNOTE‐189. Ann Oncol. 2021;32(7): 881–95. https://doi.org/10.1016/j.annonc.2021.04.008

14

Paz‐Ares L, Vicente D, Tafreshi A, Robinson A, Soto Parra H, Mazières J, et al. A randomized, Placebo‐Controlled trial of pembrolizumab plus chemotherapy in patients with metastatic squamous NSCLC: protocol‐Specified final analysis of KEYNOTE‐407. J Thorac Oncol. 2020;15(10): 1657–69. https://doi.org/10.1016/j.jtho.2020.06.015

15

Paz‐Ares LG, Ramalingam SS, Ciuleanu TE, Lee JS, Urban L, Caro RB, et al. First‐line nivolumab plus ipilimumab in advanced NSCLC: 4‐Year outcomes from the randomized, open‐label, phase 3 CheckMate 227 part 1 trial. J Thorac Oncol. 2022;17(2): 289–308. https://doi.org/10.1016/j.jtho.2021.09.010

16

Paz‐Ares L, Ciuleanu TE, Cobo M, Schenker M, Zurawski B, Menezes J, et al. First‐line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non‐small‐cell lung cancer (CheckMate 9LA): an international, randomised, open‐label, phase 3 trial. Lancet Oncol. 2021;22(2): 198–211. https://doi.org/10.1016/S1470-2045(20)30641-0

17

Boyer M, Şendur MAN, Rodríguez‐Abreu D, Park K, Lee DH, Çiçin I, et al. Pembrolizumab plus ipilimumab or placebo for metastatic non‐small‐cell lung cancer with PD‐L1 tumor proportion score ≥50%: randomized, double‐blind phase III KEYNOTE‐598 study. J Clin Oncol. 2021;39(21): 2327–38. https://doi.org/10.1200/JCO.20.03579

18

D'Andrea AD. Mechanisms of PARP inhibitor sensitivity and resistance. DNA Repair. 2018;71: 172–6. https://doi.org/10.1016/j.dnarep.2018.08.021

19

Brandts J, Ray KK. Clinical implications and outcomes of the ORION phase III trials. Future Cardiol. 2021;17(5): 769–77. https://doi.org/10.2217/fca-2020-0150

TROP2 ADC Intrigues in NSCLC. Cancer Discov 2021, 11(5): OF5. https://doi.org/10.1158/2159-8290.CD-NB2021-0314
DOI
21

Zhang J, Yi J, Zhou P. Development of bispecific antibodies in China: overview and prospects. Antibody therapeutics. 2020;3(2): 126–45. https://doi.org/10.1093/abt/tbaa011

22

Parums DV. Editorial: global regulatory initiatives deliver accelerated approval of the first bispecific therapeutic monoclonal antibody for advanced non‐small cell lung cancer (NSCLC. Med Sci Monit. 2021;27:e934854. https://doi.org/10.12659/MSM.934854

23

Qu T, Zhong T, Pang X, Huang Z, Jin C, Wang ZM, et al. Ligufalimab, a novel anti‐CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity. J Immunother Cancer. 2022;10(11): e005517. https://doi.org/10.1136/jitc-2022-005517

24

Goldman JW, Garassino MC, Chen Y, Özgüroğlu M, Dvorkin M, Trukhin D, et al. Patient‐reported outcomes with first‐line durvalumab plus platinum‐etoposide versus platinum‐etoposide in extensive‐stage small‐cell lung cancer (CASPIAN): a randomized, controlled, open‐label, phase III study. Lung Cancer. 2020;149:46–52. https://doi.org/10.1016/j.lungcan.2020.09.003

25

Paz‐Ares L, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, et al. Durvalumab, with or without tremelimumab, plus platinum‐etoposide in first‐line treatment of extensive‐stage small‐cell lung cancer: 3‐year overall survival update from CASPIAN. ESMO Open. 2022;7(2): 100408. https://doi.org/10.1016/j.esmoop.2022.100408

26

Rudin CM, Awad MM, Navarro A, Gottfried M, Peters S, Csőszi T, et al. Pembrolizumab or placebo plus etoposide and platinum as First‐Line therapy for Extensive‐Stage Small‐Cell lung cancer: randomized, Double‐Blind, phase III KEYNOTE‐604 study. J Clin Oncol. 2020;38(21): 2369–79. https://doi.org/10.1200/JCO.20.00793

27

Laird J, Lok BH, Carney B, Kossatz S, de Stanchina E, Reiner T, et al. Positron‐Emission tomographic imaging of a fluorine 18‐Radiolabeled Poly(ADP‐Ribose) polymerase 1 inhibitor monitors the therapeutic efficacy of talazoparib in SCLC Patient‐Derived xenografts. J Thorac Oncol. 2019;14(10): 1743–52. https://doi.org/10.1016/j.jtho.2019.05.032

28

Wermke M, Felip E, Gambardella V, Kuboki Y, Morgensztern D, Hamed ZO, et al. Phase I trial of the DLL3/CD3 bispecific T‐cell engager BI 764532 in DLL3‐positive small‐cell lung cancer and neuroendocrine carcinomas. Future Oncol. 2022;18(24): 2639–49. https://doi.org/10.2217/fon-2022-0196

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Publication history

Received: 10 December 2022
Accepted: 01 February 2023
Published: 24 February 2023
Issue date: February 2023

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© 2023 The Authors. Cancer Innovation published by John Wiley & Sons Ltd. on behalf of Tsinghua University Press.

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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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