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Cancer Innovation 2022, 1(4): 271-284 https://doi.org/10.1002/cai2.33
Review | Open Access | Issue | Published: 17 November 2022

Mesoscience in cell biology and cancer research

Show Author's Information Haili Qian1( ),  Adriana Sujey Beltran2( )
State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Keywords:
mesoscience, biology paradigms, oncology, integrative paradigms
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Qian H, Beltran AS. Mesoscience in cell biology and cancer research. Cancer Innovation, 2022, 1(4): 271-284. https://doi.org/10.1002/cai2.33
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Abstract Full text About this article

Mesoscale characteristics and their interdimensional correlation are the focus of contemporary interdisciplinary research. Mesoscience is a discipline that has the potential to radically update the existing knowledge structure, which differs from the conventional unit‐scale and system‐scale research models, revealing a previously untouchable area for scientific research. Integrative biology research aims to dissect the complex problems of life systems by conducting comprehensive research and integrating various disciplines from all biological levels of the living organism. However, the mesoscientific issues between different research units are neglected and challenging. Mesoscale research in biology requires the integration of research theories and methods from other disciplines (mathematics, physics, engineering, and even visual imaging) to investigate theoretical and frontier questions of biological processes through experiments, computations, and modeling. We reviewed  integrative paradigms and methods for the biological mesoscale problems (focusing on oncology research) and prospected the potential of their multiple dimensions and upcoming challenges. We expect to establish an interactive and collaborative theoretical platform for further expanding the depth and width of our understanding on the nature of biology.


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About this article

Mesoscience in cell biology and cancer research

Show Author's information Haili Qian1( ), Adriana Sujey Beltran2( )
State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Abstract

Mesoscale characteristics and their interdimensional correlation are the focus of contemporary interdisciplinary research. Mesoscience is a discipline that has the potential to radically update the existing knowledge structure, which differs from the conventional unit‐scale and system‐scale research models, revealing a previously untouchable area for scientific research. Integrative biology research aims to dissect the complex problems of life systems by conducting comprehensive research and integrating various disciplines from all biological levels of the living organism. However, the mesoscientific issues between different research units are neglected and challenging. Mesoscale research in biology requires the integration of research theories and methods from other disciplines (mathematics, physics, engineering, and even visual imaging) to investigate theoretical and frontier questions of biological processes through experiments, computations, and modeling. We reviewed  integrative paradigms and methods for the biological mesoscale problems (focusing on oncology research) and prospected the potential of their multiple dimensions and upcoming challenges. We expect to establish an interactive and collaborative theoretical platform for further expanding the depth and width of our understanding on the nature of biology.

Keywords: mesoscience, biology paradigms, oncology, integrative paradigms

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Publication history

Received: 06 October 2022
Accepted: 17 October 2022
Published: 17 November 2022
Issue date: December 2022

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© 2022 The Authors.

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This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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